The Role of Osteopromotive Membranes in Guided Bone Regeneration

Calciolari, Elena; Akcalı, Aliye; Donos, Nikolaos

doi:10.1002/9781119427926.ch5

Cited by 5 publications

(4 citation statements)

References 197 publications

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“…GBR therapy involves stimulating the reconstitution of bone and occurs mainly using membranes to isolate the damaged area from other tissues that can invade and interfere with the repair process. The membrane serves as a support, simulating the extracellular matrix found in bone composition and interaction between biomolecules and the scaffold [71]. Fibroblasts and osteoblasts found in the body play a crucial role in the homeostasis of this structure, synthesizing components of the innate immune system and inducing bone healing, respectively.…”

Section: Cell Cytotoxicitymentioning

confidence: 99%

Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration

et al. 2021

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Cellulose acetate (CA)/strontium phosphate (SrP) hybrid coating has been proposed as an effective strategy to build up novel bone-like structures for bone healing since CA is soluble in most organic solvents. Strontium (Sr2+) has been reported as a potential agent to treat degenerative bone diseases due to its osteopromotive and antibacterial effects. Herein, bioactive hybrid composite SrP-based coatings (CASrP) were successfully produced for the first time. CASrP was synthesized via a modified biomimetic method (for 7—CA7dSrP, and 14 days—CA14dSrP), in which the metal ion Sr2+ was used in place of Ca2+ in the simulated body fluid. Energy-dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR) analysis confirmed the SrP incorporation chemically in the CASrP samples. Atomic absorption spectroscopy (AAS) supported EDX data, showing Sr2+ adsorption into CA, and its significant increase with the augmentation of time of treatment (ca. 92%—CA7dSrP and 96%—CA14dSrP). An increment in coating porosity and the formation of SrP crystals were evidenced by scanning electron microscopy (SEM) images. X-ray diffraction (XRD) evidenced a greater crystallinity than CA membranes and a destabilization of CA14dSrP structure compared to CA7dSrP. The composites were extremely biocompatible for fibroblast and osteoblast cells. Cell viability (%) was higher either for CA7dSrP (48 h: ca. 92% and 115%) and CA14dSrP (48 h: ca. 88% and 107%) compared to CA (48 h: ca. 70% and 51%) due to SrP formation and Sr2+ presence in its optimal dose in the culture media (4.6–9 mg·L−1). In conclusion, the findings elucidated here evidence the remarkable potential of CA7dSrP and CA14dSrP as bioactive coatings on the development of implant devices for inducing bone regeneration.

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Section: Cell Cytotoxicitymentioning

confidence: 99%

Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration

et al. 2021

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“…However, e-PTFE can be accompanied by more serious complications such as membrane exposure and varying degrees of bacterial infection, so high-density polytetrafluoroethylene (d-PTFE) was developed. As a substitute membrane for e-PTFE, d-PTFE has a low probability of bacterial infection, which can better protect the underlying bone graft material and make it easier to remove it in the second surgery [ 6 ]. In addition, metal-based membranes such as a titanium mesh (TM) are used in GBR/GTR due to the following characteristics: high stiffness, low density, and high temperature and corrosion resistance [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…An absorbable membrane-covered TM and titanium-reinforced PTFE have been successfully used for vertical and horizontal bone regeneration around implants and are becoming commercially available. Despite the many advantages of nonabsorbable membranes, secondary surgical removal is inevitable and the increased risk of membrane exposure and bacterial infection remains [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Membranes on Vertical Bone Regeneration: A Systematic Review and Network Meta‐Analysis

Zhang

Zhou

Yun

et al. 2022

BioMed Research International

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This study is aimed at performing a systematic review and a network meta-analysis of the effects of several membranes on vertical bone regeneration and clinical complications in guided bone regeneration (GBR) or guided tissue regeneration (GTR). We compared the effects of the following membranes: high-density polytetrafluoroethylene (d-PTFE), expanded polytetrafluoroethylene (e-PTFE), crosslinked collagen membrane (CCM), noncrosslinked collagen membrane (CM), titanium mesh (TM), titanium mesh plus noncrosslinked (TM + CM), titanium mesh plus crosslinked (TM + CCM), titanium-reinforced d-PTFE, titanium-reinforced e-PTFE, polylactic acid (PLA), polyethylene glycol (PEG), and polylactic acid 910 (PLA910). Using the PICOS principles to help determine inclusion criteria, articles are collected using PubMed, Web of Science, and other databases. Assess the risk of deviation and the quality of evidence using the Cochrane Evaluation Manual, and GRADE. 27 articles were finally included. 19 articles were included in a network meta-analysis with vertical bone increment as an outcome measure. The network meta-analysis includes network diagrams, paired-comparison forest diagrams, funnel diagrams, surface under the cumulative ranking curve (SUCRA) diagrams, and sensitivity analysis diagrams. SUCRA indicated that titanium-reinforced d-PTFE exhibited the highest vertical bone increment effect. Meanwhile, we analyzed the complications of 19 studies and found that soft tissue injury and membrane exposure were the most common complications.

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“…Polytetrafluoroethylene (PTFE) is the most well-known barrier membrane for both GTR and GBR. One drawback in the use of this type of membrane is the necessity for its removal with a second-stage surgical procedure [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Resorbable Membrane Pouch Technique for Single-Implant Placement in the Esthetic Zone: A Preliminary Technical Case Report

Funato¹,

Ishikura²,

Naito³

et al. 2022

Bioengineering

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The conventional protocol for lateral guided bone regeneration (GBR) in esthetic areas requires the securing of resorbable collagen membranes using titanium cortical bone pins to immobilize bone grafts. These procedures are highly invasive and can increase patient morbidity and discomfort. Herein, we introduce a minimally invasive novel resorbable membrane pouch technique, wherein collagen membranes can be immobilized by securing them to the periosteum without the need of titanium pins. We describe 11 cases of single-immediate- or delayed-implant placement in the atrophic maxilla esthetic zone. All implants were successful and functional without pain or inflammation and with optimal soft-tissue health and esthetics. Radiographic evaluation with cone-beam computed tomography (CBCT) and esthetic assessment using the pink esthetic score (PES) were performed. At the time of implant placement, the average augmented bone width was 2.8 ± 0.6 mm on CBCT analysis. In all cases, resorption of the augmented bone was confirmed with an average of −1.3 ± 0.8 mm. Soft-tissue outcomes were scored 1 year after permanent restoration. The PES score 1 year after treatment was 11.9 ± 1.4. The resorbable membrane pouch technique with immediate or delayed implant placement for buccal dehiscence in the esthetic area can be predictable and is minimally invasive.

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The Role of Osteopromotive Membranes in Guided Bone Regeneration

Cited by 5 publications

References 197 publications

Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration

Biomimetic Strontium Substituted Calcium Phosphate Coating for Bone Regeneration

Effect of Different Membranes on Vertical Bone Regeneration: A Systematic Review and Network Meta‐Analysis

Resorbable Membrane Pouch Technique for Single-Implant Placement in the Esthetic Zone: A Preliminary Technical Case Report

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