The role of outdoor fungi on asthma hospital admissions in children and adolescents: A 5-year time stratified case-crossover analysis

Tham, Rachel; Katelaris, Constance H.; Vicendese, Don; Dharmage, Shyamali C.; Lowe, Adrian J.; Bowatte, Gayan; Taylor, Philip; Burton, Pamela; Abramson, Michael J.; Erbas, Bircan

doi:10.1016/j.envres.2016.12.016

Cited by 33 publications

(34 citation statements)

References 38 publications

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“…La detección del género Cladosporium en el aire tiene importancia para la salud humana, ya que sus esporas tienen un reconocido carácter alergénico (Tham et al 2017). Adicionalmente, pueden causar feohifomicosis en personas inmumocomprometidas (Qiu-Xia et al 2008).…”

Section: Discussionunclassified

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

Espinosa

Almaguer

Ramírez

et al. 2019

Rev. Int. Contam. Ambie.

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Palabras clave: hongos, aire, alergia, estaciones RESUMEN El clima de La Habana favorece la presencia de hongos en el aire durante gran parte del año, principalmente en el horario diurno. En los períodos poco lluviosos (noviembre-abril) se evidencian las mayores variaciones climatológicas que pueden incidir en la severidad de enfermedades alérgicas y respiratorias. El objetivo de este trabajo fue caracterizar la micobiota atmosférica diurna de La Habana durante tres períodos poco lluviosos consecutivos. Se realizaron 48 muestreos volumétricos de propágulos fúngicos viables mediante un biocolector de rendija (colector chirana) durante tres períodos poco lluviosos (noviembre/2012-abril/2013, noviembre/2013-abril/2014 y noviembre/2014-abril/2015). Los hongos recolectados se aislaron e identificaron. Simultáneamente se realizó la identificación visual de esporas en las preparaciones procedentes de un captador tipo Hirst Lanzoni VPPS 2000, en el mismo día y hora de los muestreos viables. Posteriormente se calculó la concentración, densidad y frecuencia relativa de los propágulos fúngicos identificados por ambos métodos. Los períodos evaluados fueron similares de forma cuantitativa y cualitativa. Se identificaron 32 géneros fúngicos, tres sólo mediante cultivo, 17 sólo con metodología no viable y 11 con ambos sistemas de captación. También se identificaron esporas del orden Uredinales y de la familia Xylariaceae por el método no viable. Destacaron Cladosporium, Aspergillus, Penicillium, Fusarium y Curvularia por su abundancia y frecuencia relativa. La micobiota detectada en los tres períodos fue similar en diversidad y concentración de géneros. La temperatura media y la humedad relativa media se correlacionaron con las concentraciones atmosféricas de propágulos fúngicos. Los datos aportados son útiles para la prevención de alergias y enfermedades respiratorias, con alta incidencia en la población cubana en períodos invernales y secos.

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Section: Discussionunclassified

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

Espinosa

Almaguer

Ramírez

et al. 2019

Rev. Int. Contam. Ambie.

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“…This finding is supported by Oluwole et al [45], who demonstrated that high mold levels in children's play areas are associated with current asthma (adjusted OR = 3.0, 95% CI (1.11-8.0)). Furthermore, additional studies have demonstrated that sensitization to Alternaria increases with higher mold concentration exposure and may lead to a risk of hospitalization, especially in the urban setting [46][47][48][49].…”

Section: Endotoxinmentioning

confidence: 99%

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Howard

Orhurhu

Huang

et al. 2019

Curr Allergy Asthma Rep

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Purpose of Review Asthma is a chronic respiratory condition with increasing domestic and worldwide prevalence that burdens individuals and the healthcare system with high costs associated with long-term treatments and acute emergency room (ER) visits. It can be triggered by ambient microbes, including bacteria, viruses, and fungi. In this review, we examine the outcomes of asthma patients in relation to environmental exposures to ambient microbe products, focusing on whether exposure leads to asthma development from birth to childhood and if particular microbes are associated with worsened asthma exacerbations. Recent Findings Bacterial endotoxin is more prominent in homes with pets and may cause cytokine cascades that lead to asthma exacerbation. However, some studies have demonstrated a protective effect with early exposure. Patients with positive Aspergillus skin testing are more prone to moderate-severe or severe-uncontrolled asthma. Fungal sensitization is also associated with earlier onset of asthma and demonstrates a dose-dependent relationship of symptom severity and duration. Among viruses, rhinovirus has the greatest association with decreased lung function, severe asthma, and asthma-related hospital admissions. Distribution of microbial products and associated asthma symptoms depends on the geographical climate. Genetic variations among individuals also mitigate the effects of microbial products on asthma development and symptom severity. Summary Microbial products of bacteria, fungi, and viruses are associated with the development of asthma, more severe asthma symptoms, and worse outcomes. However, some early exposure studies have also demonstrated a protective effect. Bacterial and fungal products are related to decreased lung function and earlier onset of asthma. Viral products are related to asthma-associated hospital admissions; and the climate and patient genetics can also temper or intensify the relationships between microbial products, asthma development, and asthma symptom severity. Further research should focus on the effects of early microbe exposure and its interaction with human immune systems and asthma-related outcomes.

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“…Microorganisms are essential for biodeterioration and on the production of food and medicine, although many fungi species are pathogenic, impairing health and the economy while contributing to pollution of indoor air and diseases (Ghosal;Macher;Ahmed, 2012). Tham et al (2017) mention that fungi that grow on trees, plants and grass bring about outdoor fungal spores, whereas indoor fungal spores relate to the moisture that lies on furniture. Simon-Nobbe et al (2008) state that several diseases result from inhalation, ingestion or contact with fungal spores, such as allergies, allergic bronchopulmonary mycoses, sinusitis and allergic asthma.…”

Section: IVmentioning

confidence: 99%

Análisis sobre el crecimiento de hongos en diferentes revestimientos aplicados a sistemas ligeros

et al. 2019

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The role of outdoor fungi on asthma hospital admissions in children and adolescents: A 5-year time stratified case-crossover analysis

Cited by 33 publications

References 38 publications

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

Diversidad Fúngica en La Atmósfera De La Habana (Cuba) Durante Tres Períodos Poco Lluviosos

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Análisis sobre el crecimiento de hongos en diferentes revestimientos aplicados a sistemas ligeros

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