The Role of Ovine Conceptus Secretory Proteins in the Establishment of Pregnancy

Bazer, Fuller W.; Vallet, J. L.; Ashworth, Cheryl; Anthony, Russell V.; Roberts, R. Michael

doi:10.1007/978-1-4684-1297-0_13

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…They can, for example, protect several cell types known to possess type I receptors from lysis by a range of viruses, including the commonly employed vesicular stomatis virus, with at least an equivalent potency to IFNa (71,72) and a brief written description of the crystal structure of mouse IFN/3 provided by Senda in an abstract (75). The five a-helices are A (residues 6-23), B (50-65), C (79)(80)(81)(82)(83)(84)(85)(86)(87)(88), D (112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129), and E (137)(138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148)(149)(150)(151)(152). Senda et al (75...…”

Section: A Antiviral Antiproliferative and Immunomodulatory Propermentioning

confidence: 99%

Interferons as Hormones of Pregnancy*

1992

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Section: A Antiviral Antiproliferative and Immunomodulatory Propermentioning

confidence: 99%

Interferons as Hormones of Pregnancy*

1992

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“…Embryonic development, and therefore production of IFNT, during this critical preimplantation period is reliant on maternal provision (via secretion from endometrial glands) of a complex milieu of growth factors, enzymes, cytokines, transport proteins, vitamins, minerals, amino acids, glucose and other nutrients, collectively termed histotroph (Bazer et al 1987;Gray et al 2001;Gray et al 2002;Gray et al 2006;Spencer et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of systemic progesterone during the early luteal phase on the availabilities of amino acids and glucose in the bovine uterine lumen

Mullen

Bazer

Parr

et al. 2014

Reprod. Fertil. Dev.

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Abstract. The uterine histotroph provides essential nutrition to the developing conceptus during the preimplantation period of pregnancy. The objective of the present study was to examine the effects of cycle stage and progesterone (P4) concentrations in the blood on the recoverable quantities of amino acids and glucose in the histotroph during the preimplantaion period of conceptus development. Following oestrus, dairy heifers were assigned to low, control or high P4 groups (n ¼ 6 heifers per treatment and time point). The uterine horn ipsilateral to the corpus luteum was flushed on either Day 7 or Day 13. The present study quantified 24 amino acids and glucose in the uterine flushings using HPLC and fluorometry, respectively. Heifers in the low P4 group had lower plasma concentrations of P4 throughout the cycle, whereas heifers in the high group had higher plasma concentrations of P4 between Days 3 and 7 compared with the control group (P , 0.05). Total recoverable neutral (Ser, Gln, Gly, Thr, Cit, b-Ala, Tau, Ala, Tyr, Trp, Met, Val, Phe, Ile, Leu, Pro and Cys), acidic (Glu) and basic (His, Arg, Orn and Lys) amino acids were greater (P , 0.05) on Day 13 than on Day 7. There was no significant difference in the amount of Asp or Asn between Day 7 and Day 13. The amount of amino acids recovered on Day 7 was similar across treatment groups. On Day 13, the amount of Asn, His and Thr was lower (P , 0.05) in the low P4 heifers compared with the controls and/or high P4 heifers. Quantities of glucose were not altered by cycle stage or P4 treatment. In conclusion, the stage of oestrous cycle and P4 play important roles in modulating amino acids in the histotroph, a potentially critical factor for early embryonic and/or conceptus survival.

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“…1 In ruminants, embryonic IFNs related to type I IFN, identical to the known trophoblast protein-l (TP I) or trophoblastins, playa role in the maternal recognition of pregnancy, by maintaining the corpus luteum (CL) functions. [2][3][4] Recent results indicate that equine embryos might also secrete TPI-like IFN. 5 In the pig, two IFNs are secreted on days 12 to 18 of pregnancy."…”

Section: Introductionmentioning

confidence: 99%