The role of oxidative damage and stress in aging

Bokov, Alex; Chaudhuri, Asish; Richardson, Arlan

doi:10.1016/j.mad.2004.07.009

Cited by 540 publications

(406 citation statements)

References 182 publications

Supporting

Mentioning

374

Contrasting

Unclassified

Order By: Relevance

“…Although mth mutants outlive parental control flies by of 35 % to 45 %, their flight abilities fail on the same schedule or earlier than that of controls. This is surprising because the mth gene is speculated to be involved in regulation of Drosophila's antioxidant defense system (Lin et al 1998) which mitigates the cumulative oxidative damage to DNA and cell structure that leads to eventual systemic failure during the normal aging process (Harman 1995(Harman , 2003Barja 2004;Bokov et al 2004;Landis and Tower 2005). Oxidative stress results from the presence of oxygen radicals or reactive oxygen species (ROS; e.g., hydrogen peroxide H 2 O 2 ) which are byproducts of oxygen consumption by all aerobic organisms.…”

Section: Discussionmentioning

confidence: 99%

Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels

Petrosyan

Gonçalves

Hsieh

et al. 2013

AGE

View full text Add to dashboard Cite

Methuselah (mth) is a chromosome 3 Drosophila mutant with an increased lifespan. A large number of studies have investigated the genetic, molecular, and biochemical mechanisms of the mth gene. Much less is known about the effects of mth on preservation of sensorimotor abilities throughout Drosophila's lifespan, particularly in late life. The current study investigated functional senescence in mth and its parental-control line (w1118) in two experiments that measured age-dependent changes in flight functions and locomotor activity. In experiment 1, a total of 158 flies (81 mth and 77 controls) with an age range from 10 to 70 days were individually tethered under an infrared laser-sensor system that allowed monitoring of flight duration during phototaxic flight. We found that mth has a statistically significant advantage in maintaining continuous flight over control flies at age 10 days, but not during middle and late life. At age 70 days, the trend reversed and parental control flies had a small but significant advantage, suggesting an interaction between age and genotype in the ability to sustain flight. In experiment 2, a total of 173 different flies (97 mth and 76 controls) with an age range from 50 to 76 days were individually placed in a large well-lit arena (60×45 cm) and their locomotor activity quantified as the distance walked in a 1-min period. Results showed that mth flies had lower levels of locomotor activity relative to controls at ages 50 and 60 days. These levels converged for the two genotypes at the oldest ages tested. Findings show markedly different patterns of functional decline for the mth line relative to those previously reported for other life-extended genotypes, suggesting that different life-extending genes have dissimilar effects on preservation of sensory and motor abilities throughout an organism's lifespan.

show abstract

Section: Discussionmentioning

confidence: 99%

Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels

Petrosyan

Gonçalves

Hsieh

et al. 2013

AGE

View full text Add to dashboard Cite

show abstract

“…Nous suggérons qu'une exposition modérée au stress oxydant durant la phase de maturation de l'endothélium détermine la longévité vasculaire, selon le principe bénéfique d'hormesis. < [2]. De même, la surexpression des gènes codant pour des enzymes anti-oxydantes (Cu/Zn SOD, catalase) chez des insectes n'a pas clairement permis d'allonger leur durée de vie [2].…”

Section: Définition Du Vieillissementunclassified

“…< [2]. De même, la surexpression des gènes codant pour des enzymes anti-oxydantes (Cu/Zn SOD, catalase) chez des insectes n'a pas clairement permis d'allonger leur durée de vie [2]. Ces données suggèrent donc que la théorie des radicaux libres ne peut à elle seule expliquer le processus complexe du vieillissement.…”

Section: Définition Du Vieillissementunclassified

“…Il a été amplement décrit qu'avec l'âge, le stress oxydant -défini comme un déséquilibre entre les sources oxydantes et les anti-oxydants, en défaveur de ces derniers -induit des dommages moléculaires aux lipides, aux protéines et aux acides nucléiques dans différents tissus de diverses espèces [2]. Plus d'une douzaine de mécanismes de réparation de ces dommages et de maintien de l'homéostasie ont été répertoriés [3].…”

unclassified

See 1 more Smart Citation

Âge et stress oxydant

et al. 2010

View full text Add to dashboard Cite

“…Specifically, chronic exercise has been shown to modify endogenous antioxidant protection pathways by decreasing lipid peroxidation and reducing reactive oxygen species (ROS). [64][65][66][67] One possible underlying mechanism responsible for the age-associated increase in PC incidence is oxidative damage from ROS, such as superoxide, hydroxyl radical and hydrogen peroxide; 72,73 therefore, exercise could have a negative effect on PC by reducing these free radicals. Exercise has also been shown to improve innate immune function and surveillance, [68][69][70] and previous studies have demonstrated the importance of innate immune function on PC pathogenesis.…”

Section: Proposed Molecular Mechanismsmentioning

confidence: 99%

Exercise therapy across the prostate cancer continuum

Antonelli

Freedland

Jones

2009

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Exercise has been increasingly investigated as an adjunct therapy for cancer patients. The purpose of this paper is to comprehensively review the literature regarding exercise as a therapeutic adjunct for prostate cancer (PC). Several studies in patients with PC have shown quality of life improvements associated with exercise. Although no study has established the effect of exercise as a monotherapy for PC, the molecular mechanisms responsible for the potential association between exercise and PC are being elucidated. Given the low-risk, high-reward nature of these studies, further investigations are needed to better define the function of exercise along the PC continuum.

show abstract

The role of oxidative damage and stress in aging

Cited by 540 publications

References 182 publications

Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels

Improved functional abilities of the life-extended Drosophila mutant Methuselah are reversed at old age to below control levels

Âge et stress oxydant

Exercise therapy across the prostate cancer continuum

Contact Info

Product

Resources

About