The Role of Oxidative Stress in the Etiopathogenesis of Depression

Komsiiska, Detelina; Petkov, Y.

doi:10.15547/tjs.2019.01.013

Cited by 2 publications

(3 citation statements)

References 112 publications

(63 reference statements)

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“…Depression is one of the most common psychiatric illnesses, affecting hundreds of millions of people globally [143][144][145][146] and over 17% of the population of the United States [147]. Major depressive disorder (MDD) accounts for 40% of psychiatric disorders in the United States and affects almost 350 million people around the world [148,149]. This condition is associated with a high level of morbidity and the increased risk of stroke, suicide, cardiac emergencies, hypertension and diabetes resulting in high mortality rates.…”

Section: Depress I Onmentioning

confidence: 99%

“…This condition is associated with a high level of morbidity and the increased risk of stroke, suicide, cardiac emergencies, hypertension and diabetes resulting in high mortality rates. Symptoms of MDD include apathy, anhedonia, changes in appetite and weight, psychomotor retardation/agitation, depressed mood, disrupted sleep, impaired cognition, guilt and recurrent suicidal ideation [148,150,151]. Depression creates an economic burden through loss in productivity, fatigue and mortality [152].…”

Section: Depress I Onmentioning

confidence: 99%

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Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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Neurological disorders are a significant cause of mortality and disability across the world. The current aging population and population expansion have seen an increase in the prevalence of neurological and psychiatric disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis and schizophrenia. These pose a significant societal burden, especially in low - and middle-income countries. Many neurological disorders have complex mechanisms and lack definitive cures; thus, improving our understanding of them is essential. The pathophysiology of neurological disorders often includes inflammation, mitochondrial dysfunction and oxidative stress. Oxidative stress processes, especially the generation of reactive oxygen species, are key mechanisms in the development of neurological disorders. Oxidative stress refers to an imbalance between the production of reactive oxygen species and antioxidants that can counteract them. Through their impacts on the pathophysiology of neurological disorders, nutrients with anti-inflammatory, neuroprotective and antioxidative properties have been suggested to prevent or mitigate these disorders. Certain vitamins, minerals, polyphenols and flavonoids may have therapeutic effects as adjuvant treatments for neurological disorders. Diet quality is also a risk factor for some neurological and psychiatric disorders and addressing nutritional deficiencies may alleviate symptoms. Therefore, optimizing nutritional intake may represent a potential treatment or prevention strategy. This review summarizes a selection of promising nutrients for the prevention and amelioration of neurological disorders to provide a summary for scientists, clinicians and patients, which may improve understanding of the potential benefits of nutrients in the treatment of neurological disorders.

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Section: Depress I Onmentioning

confidence: 99%

Section: Depress I Onmentioning

confidence: 99%

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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show abstract

“…A new hypothesis for post-stroke depression is the increased production of proinflammatory cytokines and the importance of specific high-risk genes. The time elapsed from stroke becomes particularly important when poststroke depression is seen as a natural psychological reaction to stroke and its consequences (18). Denial is typical in the acute phase followed by anger or frustration and weeks laterby depression.…”

Section: Introductionmentioning

confidence: 99%

Symptoms of post-stroke depression

Komsiyska¹

2019

TJS

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The purpose of this manuscript is to present our research on post-stroke depression and compare them to previous observations. Depression is a very common among disorders found in stroke patients, thus there is а high necessity in its research. We have used a contingent of 93 patients in the acute phase after stroke, which were treated at the Neurological Clinic to the University Hospital "Prof. Dr. Stoyan Kirkovich" in Stara Zagora for the period 2015 – 2016. We tested them with The Hamilton Depression Rating Scale (HAM-D-17) and analyzed the results with Statistica, version 10 (StatSoft, Inc.). We found high occurrence of depression in stroke patients. We tested for its severity and for its different symptoms in order to compare them to other studies and discover which are most common in post-stroke depression. As a conclusion, we summarize our results that among our contingent there are predominantly mild and moderate depressive disorders with reduced mood, sadness, increased psychic and somatic anxiety, insomnia, somatic complaints and superfluous hypochondriac thoughts.

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The Role of Oxidative Stress in the Etiopathogenesis of Depression

Cited by 2 publications

References 112 publications

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Symptoms of post-stroke depression

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