The Role of Oxidative Stress in Diabetic Complications

Niedowicz, Dana M.; Daleke, David L.

doi:10.1385/cbb:43:2:289

Cited by 344 publications

(244 citation statements)

References 376 publications

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“…A consistently high oxidative stress level or low antioxidant defence were revealed in patients with diabetes, which are responsible for many pathogenic processes of diabetic complications. 228 As for some other pathologies, a general protective function of Se may rely on the action of Se-proteins for ROS reduction. Several studies demonstrated that Se prevents or alleviates the adverse effects that diabetes has on cardiac and renal functions, vascular complications, and atherosclerosis progression.…”

Section: Diabetesmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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Section: Diabetesmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

View full text Add to dashboard Cite

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“…Oxidative stress plays an important role in the development of DR [119]. In this regard, it was investigated whether polymorphisms in the glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes, encoding enzymes with a role in repairing endogenous compounds affected by oxidative stress, are associated with DR. A casecontrol study including 604 Caucasians with T2D…”

Section: Diabetic Retinopathymentioning

confidence: 99%

Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications

Murea

Ma²,

Freedman³

2012

Rev Diabet Stud

297

188

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Faced with a global epidemic of type 2 diabetes (T2D), it is critical that researchers improve our understanding of the pathogenesis of T2D and related vascular complications. These findings may ultimately lead to novel treatment options for disease prevention or delaying progression. Two major paradigms jointly underlie the development of T2D and related coronary artery disease, diabetic nephropathy, and diabetic retinopathy. These paradigms include the genetic risk variants and behavioral/environmental factors. This article systematically reviews the literature supporting genetic determinants in the pathogenesis of T2D and diabetic vasculopathy, and the functional implications of these gene variants on the regulation of beta-cell function and glucose homeostasis. We update the discovery of diabetes and diabetic vasculopathy risk variants, and describe the genetic technologies that have uncovered them. Also, genomic linkage between obesity and T2D is discussed. There is a complementary role for behavioral and environmental factors modulating the genetic susceptibility and diabetes risk. Epidemiological and clinical data demonstrating the effects of behavioral and novel environmental exposures on disease expression are reviewed. Finally, a succinct overview of recent landmark clinical trials addressing glycemic control and its impact on rates of vascular complications is presented. It is expected that novel strategies to exploit the gene-and exposure-related underpinnings of T2D will soon result.

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“…O 2˙ˉ can react with nitroxide (NO˙, hereafter NO) and form strong oxidant peroxinitrite (ONOOˉ). These processes result in acute endothelium dysfunctions and activation of inflam-matory processes in blood vessels of patients with DM and they are the factors contributing to development of diabetic complications (Niedowicz and Daleke 2005;Cerielo 2006;Shahab 2006). The most known complications are cardiovascular diseases, impairment of vascular system (Liptáková 1999;Jay et al 2006), peripheral nerves, kidneys, epidermis, retina, lens, neurodegenerative diseases like Alzheimer or Parkinson diseases and others (El-Atat et al 2004;Vasavada and Agarwal 2005).…”

mentioning

confidence: 99%

Influence of pyridoxylidene aminoguanidine on biomarkers of the oxidative stress and selected metabolic parameters of rats with diabetes mellitus

Országhová¹,

Liptáková²,

Muchová³

et al. 2009

gpb

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Abstract. Oxidative damage is considered to play an important role in the pathogenesis of several diseases, such as diabetes mellitus (DM), atherosclerosis, cardiovascular complications and chronic renal failure. DM is associated with the oxidative stress and formation of advanced glycation end products (AGEs). Different drugs inhibit oxidative stress and formation of advanced glycation end products. Aminoguanidine (AG) has been proposed as a drug of potential benefit in prophylaxis of the complications of DM. Recent reports show a pro-oxidant activity of AG. Therefore we examined the effect of structural analogue of AG, its Schiff base with pyridoxal -pyridoxylidene aminoguanidine (PAG) on the level of selected markers of oxidative stress. We found that PAG decreased total damage to DNA in controls as well as in diabetic group of rats. However, we also found that PAG supplementation increases susceptibility of lipoproteins to oxidation and formation of conjugated dienes in both, diabetic as well as control animals. Its administration to diabetic rats decreases antioxidant capacity of plasma. Therefore, it is necessary to search for other structural modifications of AG that would combine its higher anti-diabetic activity with less toxicity.

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The Role of Oxidative Stress in Diabetic Complications

Cited by 344 publications

References 376 publications

Selenium biochemistry and its role for human health

Selenium biochemistry and its role for human health

Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications

Influence of pyridoxylidene aminoguanidine on biomarkers of the oxidative stress and selected metabolic parameters of rats with diabetes mellitus

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