The role of oxidative stress in hearing loss

Prell, Colleen G. Le; Miller, Josef M.

doi:10.1002/9781118832431.ch8

Cited by 6 publications

(2 citation statements)

References 93 publications

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“… 20 Insights into the quality of the various reports on human otoprotection can be obtained from the systematic review by Gupta et al, 21 which conformed with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Gupta et al 21 concluded that meta-analysis is not currently possible given the heterogeneity in methodologies and agents of interest, a finding that parallels earlier discussion of NIHL otoprotection research, with Le Prell and Miller 22 noting the challenges comparing relative efficacy of different agents tested in animal models based on the variation across study protocols.…”

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confidence: 93%

Investigational Medicinal Products for the Inner Ear: Review of Clinical Trial Characteristics in ClinicalTrials.gov

Prell

2021

J Am Acad Audiol

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Background The previous 30 years have provided information on the mechanisms of cell death in the inner ear after noise exposure, ototoxic drug injury, and during aging, and clinical trials have emerged for all of these acquired forms of hearing loss. Sudden hearing loss is less well understood, but restoration of hearing after sudden hearing loss is also a long-standing drug target, typically using steroids as an intervention but with other agents of interest as well. Purpose The purpose of this review was to describe the state of the science regarding clinical testing of investigational medicinal products for the inner ear with respect to treatment or prevention of acquired hearing loss. Data Collection and Analysis Comprehensive search and summary of clinical trials listed in the National Library of Medicine (www.ClinicalTrials.gov) database identified 61 clinical trials. Results Study phase, status, intervention, and primary, secondary, and other outcomes are summarized for studies assessing prevention of noise-induced hearing loss, prevention of drug-induced hearing loss, treatment of stable sensorineural hearing loss, and treatment of sudden sensorineural hearing loss. Conclusion This review provides a comprehensive summary of the state of the science with respect to investigational medicinal products for the inner ear evaluated in human clinical trials, and the current challenges for the field.

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confidence: 93%

Investigational Medicinal Products for the Inner Ear: Review of Clinical Trial Characteristics in ClinicalTrials.gov

Prell

2021

J Am Acad Audiol

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“…Prolonged exposure to noise rises the risk of NIHL, as stated by prior study that 89.2 dBA noise exposure for 8 hours a day caused NIHL in workers [16]. The Occupational Safety and Health Administration (OSHA) mentioned the importance of using hearing protection equipment for workers exposed to noise that exceeds the 90 dBA limit for 8 hours or more daily [17].…”

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confidence: 99%

Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage

Pratiwi,

Haryuna,

Adriztina

et al. 2024

Adv. life sci.

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Background: Cellular stress caused by noise-induced hearing loss can be observed through the damage of cochlear hair cells, mechanically and metabolically. SNR value on the DPOAE examination assesses the sensory function of cochlear outer hair cells. HSP70 as marker of cellular stress can be identified from its levels in blood and its expression in the cochlea.Methods: Three groups of rats were used for the noise intervention: Group 1 was the control group, Group 2 had a noise exposure of 100 dB, and Group 3 received a noise exposure of 110 dB. DPOAE examination was then conducted, blood samples from rats’ tail were collected after a noise treatment, followed by the measurement of HSP70 levels by ELISA readings. Rats were terminated afterwards and immunohistochemical examination of the cochlear organ of Corti was performed to calculate the expression of HSP70. The data obtained were analyzed using SPSS.Results: A decrease occurred in the values of SNR and an increase occurred in HSP70 levels in blood along with its expression in the cochlea of noise model Rattus norvegicus, and there is a correlation between the three.Conclusion: The decrease in SNR values, increase in HSP70 levels in blood, and increase in HSP70 expression in the cochlear organ of Corti of Rattus norvegicus, proves that noise-induced hearing loss triggers the production of HSP70 as a cytoprotective agent in preventing inner ear damage.Keywords: DPOAE; Rattus norvegicus; NIHL; Heat Shock Protein 70

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