The Role of Oxidative Stress in Patients With Chronic Kidney Disease

Abstract

The aim: To study the role of oxidative stress in patients with chronic kidney disease. Materials and methods: By evaluating MDA and GSH in the serum, we tried to find out how oxidative stress affects CKD patients with end-stage renal dysfunction (ESRD). The study included 90 patients with ESRD disease whom were under hemodialysis treatment, and 30 healthy control people. Results: Urea, creatinine, and MDA levels were noticeably greater in ESRD patients compared to controls, but GSH levels were noticeably lower. In conclusion, oxidative stress can cause more problems to these patients by its involvement in the appearance of metabolic and cardiovascular diseases. Conclusions: Furthermore, GSH was reduced significantly in ESRD patients and associated negatively with the level of MDA. This indicates the strong involve¬ment of antioxidants, especially GSH, in the development of oxidative stress in ESRD patients.