The Role of Oxidative Stress, Selected Metals, and Parameters of the Immune System in Male Fertility

Dobrakowski, Michał; Kaletka, Zbigniew; Machoń-Grecka, Anna; Kasperczyk, Sławomir; Horák, Stanisław; Birkner, Ewa; Zalejska–Fiolka, Jolanta; Kasperczyk, Aleksandra

doi:10.1155/2018/6249536

Cited by 21 publications

(40 citation statements)

References 41 publications

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“…In the present study, despite a significant difference between MDA levels in the studied groups, there was no correlation between MDA level and motility, which suggests a possible nonlinear dependence between these parameters in the semen of fertile males. Our previous study demonstrated that the level of MDA in seminal plasma was higher in males with asthenospermia than in controls; however, the level of MDA in spermatozoa lysate was significantly lower in males with oligospermia, asthenospermia, and oligoasthenospermia than that in the fertile controls ( Dobrakowski et al, 2018 ).…”

Section: Discussionmentioning

confidence: 84%

“…Infertility is usually defined in the biomedical context as the inability to conceive after 12 months of regular unprotected intercourse ( Greil et al, 2010 ). Infertility is among the most serious medical problems worldwide ( Dobrakowski et al, 2018 ; Mascarenhas et al, 2012 ). Male factors contribute to 40%–50% of all infertility cases, and approximately 7% of men worldwide are affected by infertility ( Agarwal and Bui, 2017 ).…”

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confidence: 99%

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Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen

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Infertility is among the most serious medical problems worldwide. Male factors contribute to 40%–50% of all infertility cases, and approximately 7% of men worldwide are affected by infertility. Spermatozoa are extremely vulnerable to oxidative insult. Oxidative stress results in axonemal damage and increased midpiece sperm morphological defects, which lead to reduced sperm motility. The aim of the study is to evaluate the association between sperm motility and the levels of selected antioxidants, cytokines, and markers of oxidative damage in the seminal plasma. The study group included 107 healthy males, who were split into two subgroups based on the percentage of motile spermatozoa after 1 hr: low motility (LM, n = 51) and high motility (HM, n = 56). The glucose-6-phosphate dehydrogenase (G6PD) activity was 52% lower in the LM group compared to that in the HM group. The level of malondialdehyde (MDA) was 12% higher in the LM group compared to that in the HM group. Similarly, the median values of interleukin (IL)-1β, IL-10, IL-12, and tumor necrosis factor alpha (TNF-α) were higher in the LM group than those in the HM group. Results of the present study revealed that the percentage of motile spermatozoa after 1 hr correlated positively with the levels of IL-1β, IL-10, IL-12, and TNFα. The lower motility of spermatozoa in healthy men is associated with a decreased activity of G6PD and increased levels of cytokines, which may be related to increased oxidative stress in seminal plasma that manifests as an increased level of MDA.

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Section: Discussionmentioning

confidence: 84%

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confidence: 99%

Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen

et al. 2020

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“…(a) F pattern corresponded to non-capacitated and acrosome intact spermatozoa (b) B pattern corresponded to capacitate and acrosome intact spermatozoa and (c) AR pattern corresponded to acrosome-reacted spermatozoa. Data were represented as mean ± SEMof 200 spermatozoa from 34 healthy donors their involvement in male fertility regulation are highly dependent on cofactors such as Zn, Se, Mg, Mn, Fe 3+ and Cu (Dobrakowski et al, 2018) whose presence in MO leaves has been validated (Dilawar et al, 2018). Centrifugation during the processing of semen increases the generation of ROS results in a loss in sperm motility and viability and induces DNA damage in spermatozoa (Henkel et al, 2012;Taherian et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Aqueous leaf extract ofMoringa oleiferareduced intracellular ROS production, DNA fragmentation and acrosome reaction in Human spermatozoa in vitro

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The effects of aqueous leaf extract of Moringa oleifera (MO) on human sperm functions and integrity was studied in vitro. Semen was obtained by masturbation after 3-5 days' abstinence from 34 healthy donors in Western Cape, South Africa. Liquefied semen was washed in human tubular fluid supplemented with 1% bovine serum albumin (HTF-BSA;1:5) with 10 min centrifugation at 300 g. Sperm suspensions were subsequently incubated with MO extract (0.625, 6.25, 62.5 and 625 µg/ ml) for 1 hr, where HTF-BSA served as control. Sperm motility, vitality, DNA fragmentation, reactive oxygen species production, mitochondrial membrane potential, capacitation and acrosome reaction were assessed. Sperm motility, vitality, mitochondrial membrane potential and capacitation remained unchanged (p > .05). A dose-dependent decrease in sperm reactive oxygen species production (p < .0001), DNA fragmentation (p < .0001) and acrosome reaction (p < .001) was observed. An increase in the percentage of non-capacitated sperm (p < .01) was noted at 625 µg/ ml. The antioxidant properties of MO actively maintained basic sperm functions, inhibited excess sperm free superoxide production and preserved acrosome reaction and DNA integrity. Further studies are needed to confirm the effect of aqueous MO leaf extract on fertility potential.

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“…The coordinated antioxidant system counteracts the destructive effects of ROS. Antioxidants play an essential role in scavenging the reactive species and preserve an adequate function of immune cells [ 29 ]. Therefore, protection of the body’s defense system can be achieved by dietary antioxidant supplementation [ 30 ].…”

Section: Case Studymentioning

confidence: 99%

The pandemic COVID-19: a tale of viremia, cellular oxidation and immune dysfunction

Rowaiye¹,

Onuh²,

Oli³

et al. 2020

Pan Afr Med J

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COVID-19, caused by SARS-CoV-2 is a tester of the immune system. While it spares the healthy, it brings severe morbidity and in a few cases, mortality to its victims. This article aims at critically reviewing the key virulence factors of COVID-19 which are the viremia, cellular oxidation and immune dysfunction. The averse economic effect of certain disease control measures such as national lock-downs and social distancing, though beneficial, makes them unsustainable. Worse still is the fact that wild animals and domestic pets are carriers of SARS-CoV-2 suggesting that the disease would take longer than expected to be eradicated globally. A better understanding of the pathological dynamics of COVID-19 would help the general populace to prepare for possible infection by the invisible enemy. While the world prospects for vaccines and therapeutic agents against the SARS-CoV-2, clinicians should also seek to modulate the immune system for optimum performance. Immunoprophylactic and immunomodulatory strategies are recommended for the different strata of stakeholders combating the pandemic with the hope that morbidities and mortalities associated with COVID-19 would be drastically reduced.

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The Role of Oxidative Stress, Selected Metals, and Parameters of the Immune System in Male Fertility

Cited by 21 publications

References 41 publications

Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen

Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen

Aqueous leaf extract ofMoringa oleiferareduced intracellular ROS production, DNA fragmentation and acrosome reaction in Human spermatozoa in vitro

The pandemic COVID-19: a tale of viremia, cellular oxidation and immune dysfunction

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