The Role of Oxidative Stress in Manganese Neurotoxicity: A Literature Review Focused on Contributions Made by Professor Michael Aschner

Abstract

This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. This review is not intended to be a systematic review of the relevant toxicologic literature. Instead, in keeping with the spirit of this special journal issue, this review highlights contributions made by Professor Michael Aschner’s laboratory in this field of study. Over the past two decades, his laboratory has made significant contributions to our scientific understanding of cellular responses that occur both in vitro and in vivo following manganese exposure. These studies have identified molecular targets of manganese toxicity and their respective roles in mitochondrial dysfunction, inflammation, and cytotoxicity. Other studies have focused on the critical role astrocytes play in manganese neurotoxicity. Recent studies from his laboratory have used C. elegans to discover new facets of manganese-induced neurotoxicity. Collectively, his body of work has dramatically advanced the field and presents broader implications beyond metal toxicology.

Assessment of cooking methods and freezing on the nutritional value and health risks of heavy metals in four fish species consumed in Douala, Cameroon

“…Manganese deficiency impairs insulin production, causes transient dermatitis, hypocholesterolemia, increased alkaline phosphatases and harmful effects on bone tissue formation. Excessive intake of manganese could lead to neurotoxicity, memory and muscular disorders [ 69 ] . Consumption of 100 g of boiled E. fimriata would cover 27.44% of this RDA.…”

Neuroprotective Effect of Resveratrol against Manganese-Induced Oxidative Stress and Matrix Metalloproteinase-9 in an “In Vivo” Model of Neurotoxicity

“…Several experimental pieces of evidence have suggested that ROS are key regulators of MMP production and that oxidative stress is a primary mechanism of Mn-mediated neurodegeneration [50][51][52][53]. In this study, we investigated whether in Mn-treated rats the increase in MMP levels and expression could be related to an alteration of the redox state in the brain.…”