The role of oxidative stress in diabetic retinopathy

Gürler, Bülent; Vural, Hüseyín; Yılmaz, Nevin; Oğuz, Halit; Satici, Ahmet; Aksoy, Nurten

doi:10.1038/eye.2000.193

Cited by 73 publications

(60 citation statements)

References 44 publications

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“…Although multiple reports [13][14][15] including ours 12 showed increased lipid peroxidation and impaired antioxidant status in diabetes and DR, little published data on protein markers of OS in both diabetes and DR patients are available. 11,16 Although ischemia modified albumin (IMA) has been demonstrated as a novel marker of ischemia, OS and endothelial dysfunction in diabetes [17][18][19] studies on IMA in DR patients are very scarce. To the best of our knowledge, there is only one study in the literature on IMA levels in human DR patients.…”

Section: Introductionmentioning

confidence: 99%

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Reddy

Sethi

Gupta

et al. 2015

Eye

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Purpose To investigate the role of protein oxidative damage and antioxidant defense in relationship to hyperglycemia measured as fasting plasma glucose (FPG), glycated hemoglobin (A1C), and duration of disease in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR). Methods This study recruited 23 nondiabetic subjects, 16 DM patients without any complications and 18 DR patients. The serum ischemia modified albumin (IMA) and glutathione (GSH) levels were measured. The IMA results were corrected for serum albumin. Between-group differences were studied by analysis of variance and betweenvariable associations were studied by Spearman's and partial correlations. Results IMA and cIMA values were elevated, whereas GSH was decreased in both patient groups vs controls (Po0.05), and the increase in IMA formation is not related to serum albumin changes. DR patients have much severe oxidative stress (OS) status with high IMA and cIMA, and low GSH than in the DM group (Po0.05). Both FPG and A1C levels were positively associated with IMA in DM group, while in the DR group, duration of disease too had a positive association with IMA. The antioxidant GSH had negative correlations with FPG (r = − 0.52, P = 0.02) and IMA (r = − 0.49, P = 0.03) in the DR group. Partial correlation analyses predicted mutual or independent associations among parameters. Conclusions Severe OS in DR has been associated with increased FPG, A1C, and disease duration. Both hyperglycemia and elevated oxidative damage detected as IMA are collectively associated with depleted GSH status. Our study unravels the need for monitoring of OS in addition to standard glycemic management in DR.

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Section: Introductionmentioning

confidence: 99%

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Reddy

Sethi

Gupta

et al. 2015

Eye

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“…While intimately linked with AGE formation, oxidative imbalances in diabetic retinopathy have also been widely reported (23)(24)(25)(26). Vitamin E (VE) can cause normalization of diabetes-related retinal blood flow abnormalities (27), while this antioxidant, in combination with vitamin C, can inhibit capillary cell death (28).…”

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confidence: 99%

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

et al. 2002

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We examined the ability of pyridoxamine (PM), an inhibitor of formation of advanced glycation end products (AGEs) and lipoxidation end products (ALEs), to protect against diabetes-induced retinal vascular lesions. The effects of PM were compared with the antioxidants vitamin E (VE) and R-␣-lipoic acid (LA) in streptozotocin-induced diabetic rats. Animals were given either PM (1 g/l drinking water), VE (2,000 IU/kg diet), or LA (0.05%/kg diet). After 29 weeks of diabetes, retinas were examined for pathogenic changes, alterations in extracellular matrix (ECM) gene expression, and accumulation of the immunoreactive AGE/ALE N -(carboxymethyl)lysine (CML). Acellular capillaries were increased more than threefold, accompanied by significant upregulation of laminin immunoreactivity in the retinal microvasculature. Diabetes also increased mRNA expression for fibronectin (2-fold), collagen IV (1.6-fold), and laminin ␤ chain (2.6-fold) in untreated diabetic rats compared with nondiabetic rats. PM treatment protected against capillary drop-out and limited laminin protein upregulation and ECM mRNA expression and the increase in CML in the retinal vasculature. VE and LA failed to protect against retinal capillary closure and had inconsistent effects on diabetes-related upregulation of ECM mRNAs. These results indicate that the AGE/ALE inhibitor PM protected against a range of pathological changes in the diabetic retina and may be useful for treating diabetic retinopathy.

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“…Increase in reactive oxygen species in diabetes mellitus is due to autooxidation of glucose, protein glycosylation and active polyol pathway (20). The membrane protein glycosylation enhancement occurring in diabetes could be one of the reasons for lowered erythrocyte membrane fluidity in diabetes (21).…”

Section: Discussionmentioning

confidence: 99%

Comparison between erythrocyte hemoglobin and spectrin glycosylation and role of oxidative stress in type-2 diabetes mellitus

Mahindrakar

Suryakar

Ankush

et al. 2007

Indian J Clin Biochem

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The role of oxidative stress in diabetic retinopathy

Cited by 73 publications

References 44 publications

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

Comparison between erythrocyte hemoglobin and spectrin glycosylation and role of oxidative stress in type-2 diabetes mellitus

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