The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma

Topić, Aleksandra; Francuski, Djordje; Nikolić, Aleksandra; Milošević, Katarina; Jovičić, Snežana; Marković, Bojan; Djukić, Mirjana; Radojković, Dragica

doi:10.1080/15513815.2017.1315199

Cited by 12 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it was shown that toxic chemicals in tobacco smoke are able to induce epigenetic changes with increased expression of various pro-inflammatory genes (57). Therefore, prenatal and postnatal exclusion of tobacco smoke exposure could be used as an important preventive approach against allergic sensitization and inflammation development with the attenuation of oxidative stress (58). Prenatal supplementation of vitamin C and E improved pulmonary functions of newborns of smoking mothers (59), but in a large placebo-controlled study, this effect was not confirmed (60).…”

Section: Antioxidant Strategies For Asthma Treatmentmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

View full text Add to dashboard Cite

Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

show abstract

Section: Antioxidant Strategies For Asthma Treatmentmentioning

confidence: 99%

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

2017

View full text Add to dashboard Cite

show abstract

“…10,11 Urinary concentrations of adenosine have been measured in healthy children, 12,13 and few patients with miscellaneous conditions such as inherited metabolic disorders, cardiomyopathy, and respiratory failure. 13 Urinary measurements of 8-OxodG have been conducted in healthy children, 14 contemporary patients with cystic fibrosis, 15 and subjects exposed to environmental pollutants, 16,17 including asthmatic patients exposed to tobacco smoke. 17 Whereas some knowledge of FE NO and partitioned-NO is available in relation with EIB, no information exists on the role of urinary purine metabolites in assessing EIB in asthmatic children.…”

mentioning

confidence: 99%

“…13 Urinary measurements of 8-OxodG have been conducted in healthy children, 14 contemporary patients with cystic fibrosis, 15 and subjects exposed to environmental pollutants, 16,17 including asthmatic patients exposed to tobacco smoke. 17 Whereas some knowledge of FE NO and partitioned-NO is available in relation with EIB, no information exists on the role of urinary purine metabolites in assessing EIB in asthmatic children.…”

mentioning

confidence: 99%

Urinary and exhaled biomarkers of exercise‐induced bronchoconstriction in atopic asthmatic children

Barreto

Capi²,

Lionetto³

et al. 2019

Pediatric Pulmonology

View full text Add to dashboard Cite

Background Exercise‐induced bronchoconstriction (EIB) reflects poor asthma control. Assessing noninvasive biomarkers associated with EIB could help to monitor patients in the pediatric age. Aims To test exhaled and urinary biomarkers for assessing EIB in atopic asthmatic children. Methods In 45 atopic patients (11.1 ± 1.8 years, 25 males) we measured the fractional exhaled nitric oxide (FENO), its alveolar (CaNO), and bronchial (J’awNO) components corrected for the trumpet shape of the airways and axial NO diffusion (TMAD), concentrations of urinary adenosine and 8‐hydroxy‐2'‐deoxyguanosine (8‐OxodG), blood eosinophils count, total immunoglobulin E , skin prick tests, and baseline spirometry before a treadmill exercise challenge. Forty healthy control subjects participated solely to baseline measurements. Results Patients yielded higher FENO and urinary adenosine concentrations than healthy controls. After the challenge, 18 patients (40%) had EIB; these patients had higher levels of CaNO, CaNO TMAD, and urinary adenosine than patients without EIB. Baseline spirometry, FE NO, JawNO, JawNO TMAD, urinary 8‐OxodG, allergy, and blood eosinophil counts were found similar in both groups. In multiple linear regression, the fall in FEV 1 was explained by CaNO TMAD, urinary adenosine and blood eosinophil count, whereas the fall in FEF 25‐75 was explained by CaNO TMAD and blood eosinophil count. Both CaNO TMAD ≥10.5 ppb and urinary adenosine ≥406 nmol/mmol Cr predicted a fall in FEV 1 ≥10%, while only CaNO TMAD ≥10.5 ppb predicted a fall in FEF 25‐75 ≥26%. Conclusion Concentrations of peripheral airway NO are complementary with urinary adenosine for assessing EIB and promising tools of asthma control in pediatric patients with the atopic phenotype.

show abstract

“…Besides inflammation in the airways, bronchoconstriction may also be triggered by various types of proteolytic and oxidative damage. Therefore, it is argued that anti-inflammatory and anti-oxidant agents will prevent the triggering of bronchoconstriction which constitutes the fundamental mechanism in asthma (4,6,9,12). It has been reported that zinc, which has anti-oxidant, anti-apoptotic, anti-inflammatory and anti-allergic properties, is important in dermatologic and respiratory diseases, while zinc deficiency plays an important role in the pathogenesis and severity of dermatologic and respiratory diseases (2,8,11).…”

Section: Discussionmentioning

confidence: 99%

“…More recent studies also showed that bronchoconstriction is triggered by proteolytic and oxidative damage in the airway epithelium in addition to airway inflammation (2,4). The airway epithelium may be affected by oxidative damage caused by inflammatory cells and oxidant agents in the air (5,6). Zinc is an essential dietary factor which has anti-inflammatory and anti-oxidant properties, and it is found in the contents of numerous cells of human body and structures of various enzymes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Çocukluk Çaği Astiminin Kontrol Ve Şi̇ddet Düzeyi̇ İle Serum Çi̇nko Düzeyleri̇ Arasindaki̇ İli̇şki̇

Elmas¹,

Özdemir²

2018

Kocatepe Tıp Dergisi

View full text Add to dashboard Cite

Çocukluk çağı astımı multifaktöriyel bir hastalıktır. Patogenezinde anti-inflamatuvar ve anti-oksidan ajanların önemli rol oynadığı bilinir. Bununla birlikte anti oksidan çinko gibi eser elementlerin rolü ile ilgili farklı görüşler mevcuttur. Bizim çalışmamızın amacı astım kontrol ve şiddeti ile serum çinko düzyleri arasındaki ilişkiyi belirlemekti. GEREÇ VE YÖNTEM:Çalışmaya Temmuz 2014 ile Nisan 2015 tarihleri arasında 3-17 yaş arası astım tanısı almış 56 hasta ve 26 sağlıklı çocuk alındı. Astım kontrol düzeyleri GINA 2014 kriterlerine göre belirlendi. Serum çinko düzeyleri atomic absorbsiyon spektroskopi metodu ile çalışıldı. Yapılabilen hastalara solunum fonksiyon testleri uygulandı.BULGULAR: Astım ve kontrol grubu serum çinko düzeyleri arasında anlamlı fark bulunmadı. Serum çinko düzeyleri tam kontrollü astım grubuna göre kısmi kontrollü astım grubunda anlamlı şekilde yüksek bulundu (p=0.023). Astım kontrol düzeyi ile serum çinko düzeyleri arasında anlamlı negative korelasyon izlendi (r: -0.437, p=0.001). FVC %80 altında olan grupta serum çinko düzeyleri anlamlı şekilde yüksek bulundu (p=0.001). Astım şiddet düzeyine göre serum çinko düzeyleri arasında fark bulunmadı (p=0.228). Astım şiddeti ile serum çinko düzeyleri arasında anlamlı korelasyon saptanmadı (r=0.168, p=0.217). SONUÇ:Serum çinko düzeyleri çocuklarda astım kontrolü ile ilişkili idi. Serum çinko düzeyleri astım kontrol düzeylerini belirlemede diğer parametrelere destekleyici olarak düşünülebilir.

show abstract

The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma

Abstract: The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements.

Cited by 12 publications

References 27 publications

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

Urinary and exhaled biomarkers of exercise‐induced bronchoconstriction in atopic asthmatic children

Çocukluk Çaği Astiminin Kontrol Ve Şi̇ddet Düzeyi̇ İle Serum Çi̇nko Düzeyleri̇ Arasindaki̇ İli̇şki̇

Contact Info

Product

Resources

About