The Role of Oxygen Free Radicals in Acute Renal Failure Complicating Obstructive Jaundice: An Experimental Study

Yüceyar, Serdar; Gümüştaş, Koray; Ertürk, Süphan; Hamzaoğlu, İsmail; Uygun, Nesrin; Ayaz, Meltem; Cengiz, A. Tevfik; Kafadar, Y

doi:10.1155/1998/47363

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…This is in accordance with previous studies that reported renal injury to be linked with depletion or reduction in the glutathione content [25,26]. The decrease in SOD levels is also in harmony with the previous findings [27,28]. Dobashi et al [27] demonstrated mRNA levels of CAT significantly decreased after I/R.…”

Section: Discussionsupporting

confidence: 93%

Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys

Bayrak¹,

Bavbek²,

Karataş³

et al. 2008

Nephrology Dialysis Transplantation

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Background: Renal ischaemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts, which is a complex pathophysiologic process involving hypoxia and free radical (FR) damage. The oil of Nigella sativa (NSO) has been subjected to considerable pharmacological investigations that have revealed its antioxidant activity in different conditions. But there is no previously reported study about its effect on ischaemia/reperfusion (I/R) injury of kidneys. The aim of this study was to investigate the possible effects of NSO in I/R-induced renal injury in rats. Methods: Thirty healthy male Wistar albino rats were randomly assigned to one of the following groups: control, sham, I/R, NSO+I/R, I/R+NSO and NSO. I/R, NSO+I/R and I/R+NSO rats were subjected to bilateral renal ischaemia followed by reperfusion and then all the rats were killed and kidney function tests, serum and tissue oxidants and antioxidants were determined and histopathological examinations were performed. Results: Pre-and post-treatment with NSO produced reduction in serum levels of blood urea nitrogen (BUN) and creatinine caused by I/R and significantly improved serum enzymatic activities of superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) and also tissue enzymatic activities of catalase (CAT), SOD and GSH-Px. NSO treatment resulted in lower total oxidant status (TOS) and higher total antioxidant capacity (TAC) levels and also significant reduction in serum and tissue malondialdehyde (MDA), nitric oxide (NO) and protein carbonyl content (PCC) that were increased by renal I/R injury. The kidneys of untreated ischaemic rats had a higher histopathological score, while treatment with NSO nearly preserved the normal morphology of the kidney. Conclusions: In view of previous observations and our data, with the potent FR scavenger and antioxidant propCorrespondence and offprint requests to: Nuket Bavbek, Dikmen Yildizi Sokak 10/8, DI . KMEN/ANKARA, 06460, Turkey. Tel: +90-0312-4838985/-4400606; Fax: +90-0312-2306080; E-mail: ntbavbek@yahoo.com erties, NSO seems to be a highly promising agent for protecting tissues from oxidative damage and preventing organ damage due to renal I/R.

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Section: Discussionsupporting

confidence: 93%

Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys

Bayrak¹,

Bavbek²,

Karataş³

et al. 2008

Nephrology Dialysis Transplantation

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“…Although the pathogenesis of the underlying renal dysfunction during ischemia-reperfusion is compli cated, free radicals and oxidative stress have been exten sively implicated in the pathogenesis of ischemia-reper fusion injury (2,3,16). Free radicals are highly reactive and injure lipids, proteins and nucleic acids, resulting in structural and functional impairment.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, the events occurring during ischemia-reperfu sion have been examined, and various mechanisms have been proposed to explain the origins of tissue injury. Among these, it has been widely accepted that reactive oxygen species participate in the pathogenesis of ischemic acute renal failure (2,3). Therefore, investi gations of amelioration or prevention of cellular injury after renal ischemia through manipulation of free radi cal production have received much attention and indi cated that antioxidants have therapeutic potential (4,5).…”

mentioning

confidence: 99%

Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds

Nakagawa¹,

Yokozawa²,

Satoh³

et al. 2005

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of proanthocyanidin-rich extract in rats subjected to renal ischemia-reperfusion were examined. Proanthocyanidin-rich extract, which is prepared from grape seeds (Vitis vinifera L.), was given orally at doses of 5 and 10mg/kg body weight/ d for 20 consecutive days prior to ischemia-reperfusion. Administration of proanthocyani din-rich extract attenuated renal dysfunction, as indicated by serum urea nitrogen and cre atinine levels. Additionally, in the ischemic-reperfused kidneys, increased levels of thiobarbituric acid (TBA)-reactive substance and alterations of antioxidant enzyme activi ties such as superoxide dismutase, catalase and glutathione peroxidase (GSH-Px) were observed. Proanthocyanidin-rich extract-treated groups showed significantly reduced renal TBA-reactive substance levels and enhanced catalase and GSH-Px activities, These results suggest that proanthocyanidin-rich extract has protective effects against ischemic-reperfu sion-induced renal damage associated with oxidative stress.

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“…It has been proposed that in obstructive jaundice, bilirubin and bile salts disrupt cellular metabolism and membrane transport systems and decrease the rate of cellular respiration. In addition, bile salts inhibit ATPase activity in renal cells and exert disruptive effects on renal cellular and lysosomal membranes [5,6,11].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies and observations suggest that the FORs produced in obstructive jaundice may play a significant role in the etiopathogenesis of ARF [5,6].…”

Section: Introductionmentioning

confidence: 99%

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

Küçük¹,

Sözüer²,

Ikizceli³

et al. 2003

Eur Surg Res

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Obstructive jaundice is associated with high morbidity and mortality. Major complications such as pulmonary dysfunction, renal failure and sepsis are frequently encountered. Recent studies and observations suggest that the free oxygen radicals (FORs) produced in obstructive jaundice may play a significant role in the etiopathogenesis of acute renal failure (ARF). Thirty rats were divided into three groups, as sham, control and treatment groups containing 10 rats each. Laparatomy was performed on each animal in the control and treatment groups and common bile ducts were ligated. Common bile duct was observed but was not ligated for the rats in the sham group. Saline solution injection was begun on the first day of surgical procedure and repeated once a day during the following 5 days. The same procedure was performed with oxygen radical scavenger dimethyl sulfoxide (1.5 mg/kg/day i.p.) instead of saline in the treatment group. The rats were sacrificed on the 7th postoperative day. On the 7th postoperative day, the bilirubin, urea and creatinine levels of the control and treatment groups were significantly higher in comparison with the sham group (p < 0.01). Although there was no statistically significant difference between the bilirubin levels of the control and treatment groups (p > 0.05), the urea and creatinine levels in the treatment group were significantly lower (p < 0.01). On the 7th postoperative day, the erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels of the control and treatment groups were significantly lower than those of the sham group (p < 0.01), whereas renal and erythrocyte malondialdehyde (MDA) levels were significantly higher (p < 0.01). Although SOD and GSH-Px levels did not differ significantly between the treatment and control groups (p > 0.05), renal and erythrocyte MDA levels of the treatment group were significantly lower than those of the control group (p < 0.01). The histopathological scores were significantly higher in the control and treatment groups (p < 0.01); there was no significant difference between the control and treatment groups (p > 0.05). FORs seem to play a significant role in the etiopathogenesis of renal failure in obstructive jaundice. Antioxidant treatment may decrease oxidative damage due to FORs and may prevent renal failure.

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The Role of Oxygen Free Radicals in Acute Renal Failure Complicating Obstructive Jaundice: An Experimental Study

Cited by 11 publications

References 12 publications

Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys

Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys

Attenuation of Renal Ischemia-Reperfusion Injury by Proanthocyanidin-Rich Extract from Grape Seeds

Role of Oxygen Free Radical Scavengers in Acute Renal Failure Complicating Obstructive Jaundice

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