The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders

Abramova, Olga; Zorkina, Yana; Ushakova, Valeria; Зубков, Э. А.; Morozova, Anastasia; Чехонин, В. П.

doi:10.1016/j.npep.2020.102079

Cited by 51 publications

(37 citation statements)

References 134 publications

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“…In addition, V 1A ‐R and OT‐R do not act only in epilepsy. By modulating the activity of limbic structures, like the frontal lobe and amygdala, these receptors can modulate distinct behavioral and emotional responses 16,56,57 . Our study showed that Avpr1a expression was lower in WARs than in Wistar rats in both the frontal lobe and central amygdala, without significant changes in Oxtr expression in the studied brain areas.…”

Section: Discussionmentioning

confidence: 55%

“…The oxytocin and vasopressin neurons project from the hypothalamus to many brain regions, 55,56 and their receptors, OT‐R and V 1A ‐R, are both present in the majority of these regions, leading to a wide range of physiological and behavioral responses 55,57 . When activated, these receptors can present different, even opposite, effects according to the region in which they are expressed 57 .…”

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine changes in the hypothalamic‐neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling

Valentim-Lima

Oliveira²,

Antunes‐Rodrigues³

et al. 2021

J Neuroendocrinology

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The Wistar audiogenic rat (WAR) strain is used as an animal model of epilepsy, which when submitted to acute acoustic stimulus presents tonic-clonic seizures, mainly dependent on brainstem (mesencephalic) structures. However, when WARs are exposed to chronic acoustic stimuli (audiogenic kindling-AK), they usually present tonic-clonic seizures, followed by limbic seizures, after recruitment of forebrain structures such as the cortex, hippocampus and amygdala. Although some studies have reported that hypothalamic-hypophysis function is also altered in WAR through modulating vasopressin (AVP) and oxytocin (OXT) secretion, the role of these neuropeptides in epilepsy still is controversial. We analyzed the impact of AK and consequent activation of mesencephalic neurocircuits and the recruitment of forebrain limbic (LiR) sites on the hypothalamic-neurohypophysial system and expression of Avpr1a and Oxtr in these structures. At the end of the AK protocol, nine out of 18 WARs presented LiR. Increases in both plasma vasopressin and oxytocin levels were observed in WAR when compared to Wistar rats. These results were correlated with an increase in the expressions of heteronuclear (hn) and messenger (m) RNA for Oxt in the paraventricular nucleus (PVN) in WARs submitted to AK that presented LiR.In the paraventricular nucleus, the hnAvp and mAvp expressions increased in WARs with and without LiR, respectively. There were no significant differences in Avp and Oxt expression in supraoptic nuclei (SON). Also, there was a reduction in the Avpr1a expression in the central nucleus of the amygdala and frontal lobe in the WAR strain.In the inferior colliculus, Avpr1a expression was lower in WARs after AK, especially those without LiR. Our results indicate that both AK and LiR in WARs lead to changes in the hypothalamic-neurohypophysial system and its receptors, providing a new molecular basis to better understaind epilepsy.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Neuroendocrine changes in the hypothalamic‐neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling

Valentim-Lima

Oliveira²,

Antunes‐Rodrigues³

et al. 2021

J Neuroendocrinology

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“…Importantly, L-DE-71 also reduced Oxt transcripts in the SON. Because local release of OXT from SON dendrites that extend to MeA promotes social recognition through amygdalar OXTR 134, 135 , downregulated SON Oxt may underlie, in part, the associated SNP and SMR deficits. OXT in the BNST also drives stress-induced social vigilance and avoidance that may be at play in social behavior domains examined here 136 .…”

Section: Discussionmentioning

confidence: 99%

Section: Perinatal De-71 Alters Avp and Otergic Neuromolecular Phenotypes In Brain Regions That Coordinate Complex Social Behaviorsmentioning

confidence: 99%

Persistent autism-relevant phenotype produced by in utero and lactational exposure of female mice to the commercial PBDE mixture, DE-71

Kozlova

Valdez

Denys

et al. 2021

Preprint

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Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum disorders (ASD), characterized by abnormal psychosocial functioning, although direct evidence is currently lacking. Using a translational exposure model, we tested the hypothesis that maternal transfer of a commercial mixture of PBDEs, DE-71, produces ASD-relevant behavioral and neurochemical deficits in female offspring. C57Bl6/N mouse dams (F0) were exposed to DE-71 via oral administration of 0 (VEH/CON), 0.1 (L-DE-71) or 0.4 (H-DE-71) mg/kg bw/d from 3 wk prior to gestation through lactation. Mass spectrometry analysis indicated in utero and lactational transfer of PBDEs (ppb) to F1 female offspring brain tissue at postnatal day (PND) 15 which was reduced by PND 110. Neurobehavioral testing of social novelty preference (SNP) and social recognition memory (SRM) revealed that adult L-DE-71 F1 offspring display altered short- and long-term SRM, in the absence of reduced sociability, and increased repetitive behavior. These effects were concomitant with reduced olfactory discrimination of social odors. Additionally, L-DE-71 exposure also altered short-term novel object recognition memory but not anxiety or depressive-like behavior. Moreover, F1 L-DE-71 displayed downregulated mRNA transcripts for oxytocin (Oxt) in the bed nucleus of the stria terminalis (BNST) and supraoptic nucleus, vasopressin (Avp) in the BNST and upregulated Avp1ar in BNST, and Oxtr in the paraventricular nucleus. Our work demonstrates that developmental PBDE exposure produces ASD-relevant neurochemical, olfactory processing and behavioral phenotypes that may result from early neurodevelopmental reprogramming within central social and memory networks.

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“…CC-BY-NC 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is The copyright holder for this preprint this version posted May 23, 2021. ; https://doi.org/10.1101/2021.05.21.445212 doi: bioRxiv preprint Qian Zhuang 4 humans have also reported similar effects of AVP on social recognition memory, social cooperation and decision making (Abramova et al, 2020;Albers, 2012;Caldwell, 2017;Guastella et al, 2010Guastella et al, , 2011Zink et al, 2011), the specific role of this peptide in modulating social attention in humans has not been established, although an early study in rats has reported effects of an AVP metabolite on selective attention (Bunsey et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

Zhuang

Zheng

Becker

et al. 2021

Preprint

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The respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in modulating social cognition and for therapeutic intervention in autism spectrum disorder have not been fully established. In particular, while numerous studies have demonstrated effects of oxytocin in promoting social attention the role of AVP has not been examined. The present study employed a randomized, double-blind, placebo (PLC)-controlled between-subject design to explore the social- and emotion-specific effects of AVP on both bottom-up and top-down attention processing with a validated emotional anti-saccade eye-tracking paradigm in 80 male subjects (PLC = 40, AVP = 40). Our findings showed that AVP increased the error rate for social (angry, fearful, happy, neutral and sad faces) but not non-social (oval shapes) stimuli during the anti-saccade condition and reduced error rates in the pro-saccade condition. Comparison of these findings with a previous study (sample size: PLC = 33, OXT = 33) using intranasal oxytocin revealed similar effects of the two peptides on anti-saccade errors but a significantly greater effect of AVP on pro-saccades. Both peptides also produced a post-task anxiolytic effect by reducing state anxiety. Together these findings suggested that both AVP and OXT decrease goal-directed top-down attention control to social salient stimuli but that AVP more potently increased bottom-up social attentional processing.

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The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders

Cited by 51 publications

References 134 publications

Neuroendocrine changes in the hypothalamic‐neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling

Neuroendocrine changes in the hypothalamic‐neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling

Persistent autism-relevant phenotype produced by in utero and lactational exposure of female mice to the commercial PBDE mixture, DE-71

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

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