THE RÔLE OF p-AMINOBENZOATE IN PANTOATE SYNTHESIS BY BACTERIUM LINENS

Purko, M.; Wo, Nelson; Wa, Wood

doi:10.1016/s0021-9258(18)71244-1

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The Initial Precursor1

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2004

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Cited by 29 publications

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“…35 This activity was stimulated by the addition of divalent metal ions and to some extent by the addition of tetrahydrofolate. This finding was supported by earlier data that p-aminobenzoic acid (PABA) was involved in pantothenate metabolism [36][37][38] and suggested a mechanism analogous to that reported for serine hydroxymethyltransferase. 39 The enzyme was purified to a greater level of homogeneity by Teller et al 40 and this purified enzyme preparation was found to be dependent on 5,10-methylenetetrahydrofolate.…”

Section: The Initial Precursorsupporting

confidence: 83%

Biosynthesis of pantothenate

2004

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Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included.

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