The Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage

Turgut, Seda; İlhan, Muzaffer; Turan, Saime; Karaman, Ozcan; Yaylım, İlhan; Küçükhüseyin, Özlem; Taşan, Ertuğrul

doi:10.21873/invivo.11067

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…rs11515 has a higher minor allelic frequency, 0.16, in Africans (Kitts and Sherry, 2011). Several studies have shown a potential role for rs11515 in tumour development and a functional relationship between rs11515 and a microRNA binding site (Chen et al, 2008;Landi et al, 2008;Robertson et al, 2010;Turgut et al, 2017). It has been reported that rs11515 is commonly associated with aggressive breast cancer in patients from New Zealand (Royds et al, 2016) although, in contradiction, a recent meta-analysis did not show an association with breast cancer in an Asian population (Dong et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Identification of CDKN2A variants in breast cancer patients in Pakistan

et al. 2019

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The role of cyclin-dependent kinase inhibitor 2A gene (CDKN2A) variants in breast cancer is not well understood, here we investigated their possible effects on breast cancer in Pakistani women attending the NORI Hospital, Islamabad. Direct DNA sequencing of CDKN2A identified an already known polymorphism in the 3′ UTR, c.*29G > C (rs11515), in 5.88% patients and two novel variants. One, a deep intronic substitution (c.458-554T > G) in 1.96% patients, is also detected as a compound heterozygous form along with c.*29G > C in 1.96% patients (c.[458-554T > G; *29G > C]). The other is a novel deletion (c.458-82delG) occurring as a compound variant with two other identified variants c.[458-554T > G; 458-82delG; *29G > C] in 1.96% patients. In silico pathogenicity prediction analyses did not predict pathogenic effects on breast cancer for these individual variants. We conclude that variations in CDKN2A are not the major genetic cause of breast cancer in the enrolled Pakistani patients.

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Section: Discussionmentioning

confidence: 99%

Identification of CDKN2A variants in breast cancer patients in Pakistan

et al. 2019

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Association of polymorphism in P16 and myeloperoxidase genes with susceptibility to oral lesions in North Indian population

et al. 2018

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A research on the protein expression of p53, p16, and MDM2 in endometriosis

2019

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This study aims to examine the expression of p53, p16, and murine double minute 2 (MDM2) protein in normal endometrium and endometriosis, in order to discuss the role of p53, p16, and MDM2 protein and apoptosis in the pathogenesis and development of endometriosis, and provide a theoretical basis for clinical diagnosis and treatment. The immunohistochemical streptavidin-biotin peroxidase method was used to detect the expression of p53, p16, and MDM2 in tissue samples obtained from 30 women with pathologically confirmed ovarian endometriosis and 29 women with pathologically confirmed normal endometrium. The relationship between p53, p16, and MDM2 expression and apoptosis was analyzed. In normal endometrium, the positive rate of p53 in the secretory phase was higher than that in the proliferative phase ( P < .05). Furthermore, the positive rate of p53 in normal endometrium was higher than that in ovarian endometriosis ( P < .05). There was a significant difference between normal endometrium and ovarian endometriosis. The positive rate of p16 in normal endometrium was higher than that in ovarian endometriosis ( P < .05). Furthermore, there was a significant difference between normal endometrium and ovarian endometriosis. The positive rate of MDM2 in normal endometrium was lower than that in ovarian endometriosis ( P < .05). In ovarian endometriosis, the expression of p53 and p16 was positively correlated with each other ( r = 0.611, P < .01). However, the expression of p53 and MDM2 was negatively correlated with each other ( r = −0.541, P < .01). Furthermore, the expression of p16 and MDM2 might not be relevant in the endometriosis ( r = 0.404, P > .05). As important apoptosis regulatory genes, p53, p16, and MDM2 might be involved in the pathogenesis and development of endometriosis.

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The Role of p16 and MDM2 Gene Polymorphisms in Prolactinoma: MDM2 Gene Polymorphisms May Be Associated with Tumor Shrinkage

Cited by 3 publications

References 39 publications

Identification of CDKN2A variants in breast cancer patients in Pakistan

Identification of CDKN2A variants in breast cancer patients in Pakistan

Association of polymorphism in P16 and myeloperoxidase genes with susceptibility to oral lesions in North Indian population

A research on the protein expression of p53, p16, and MDM2 in endometriosis

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