The Role of p53 Family in Cancer

Zawacka-Pankau, Joanna

doi:10.3390/cancers14030823

Cited by 24 publications

(14 citation statements)

References 15 publications

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“…Transcription factor p53 encoded by the TP53 gene regulates expression of genes engaged in many cellular processes such as cell cycle, apoptosis, senescence and DNA repair. Its activity is ubiquitously lost in human cancer cells either by mutation of the TP53 gene itself or by loss of cell signaling upstream or downstream of p53 ( 73 , 74 ). TP53 single nucleotide polymorphism c.639A>G was reported to have a statistically significant association with NSCLC ( 75 ).…”

Section: Germ-line Polymorphismmentioning

confidence: 99%

Genetic differences between smokers and never-smokers with lung cancer

Kuśnierczyk

2023

Front. Immunol.

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Smoking is a major risk factor for lung cancer, therefore lung cancer epidemiological trends reflect the past trends of cigarette smoking to a great extent. The geographic patterns in mortality closely follow those in incidence. Although lung cancer is strongly associated with cigarette smoking, only about 15% of smokers get lung cancer, and also some never-smokers develop this malignancy. Although less frequent, lung cancer in never smokers is the seventh leading cause of cancer deaths in both sexes worldwide. Lung cancer in smokers and never-smokers differs in many aspects: in histological types, environmental factors representing a risk, and in genes associated with this disease. In this review, we will focus on the genetic differences between lung cancer in smokers versus never-smokers: gene expression, germ-line polymorphisms, gene mutations, as well as ethnic and gender differences. Finally, treatment options for smokers and never-smokers will be briefly reviewed.

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Section: Germ-line Polymorphismmentioning

confidence: 99%

Genetic differences between smokers and never-smokers with lung cancer

Kuśnierczyk

2023

Front. Immunol.

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“…Zawacka‐Pankau 282 provides comprehensive coverage of the most recent facts on the structure, function, and prospective targeting of the p53 protein family for improved cancer therapy. The p53 protein family has one member, P53, which has undergone the most in‐depth characterization.…”

Section: Literature Reviewmentioning

confidence: 99%

A comprehensive study of p53 protein

Patil

Bihari

2022

J of Cellular Biochemistry

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The protein p53 has been extensively investigated since it was found 43 years ago and has become a "guardian of the genome" that regulates the division of cells by preventing the growth of cells and dividing them, that is, inhibits the development of tumors. Initial proof of protein existence by researchers in the mid-1970s was found by altering and regulating the SV40 big T antigen termed the A protein. Researchers demonstrated how viruses play a role in cancer by employing viruses' ability to create T-antigens complex with viral tumors, which was discovered in 1979 following a viral analysis and cancer analog research. Researchers later in the year 1989 explained that in Murine Friend, a virus-caused erythroleukemia, commonly found that p53 was inactivated to suggest that p53 could be a "tumor suppressor gene." The TP53 gene, encoding p53, is one of human cancer's most frequently altered genes. The proteinregulated biological functions of all p53s include cell cycles, apoptosis, senescence, metabolism of the DNA, angiogenesis, cell differentiation, and immunological response. We tried to unfold the history of the p53 protein, which was discovered long back in 1979, that is, 43 years of research on p53, and how p53's function has been developed through time in this article.

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“…However, the role of germline mutations in TP53 is not completely understood in CaP. Some studies point to the role of specific TP53 SNPs as a possible risk factor for CaP [11,12]. Polymorphisms in codons 47 and 72 in the TP53 tumor suppressor gene have been shown to affect phosphorylation and the expression of pro-apoptotic genes, respectively, both of which could increase cancer risk [13].…”

Section: Introductionmentioning

confidence: 99%

Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men

Duncan¹,

Nousome²,

Ricks³

et al. 2023

Preprint

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Growing evidence indicates the involvement of a genetic component for CaP susceptibility and clinical severity. Somatic mutations of TP53 have been associated with 50% of diverse human cancers. Studies have also reported the role of germ line mutations and single nucleotide poly-morphisms (SNPs) of TP53 as possible risk factors for cancer development. In this single De-partment of Defense institutional retrospective study, we identified common SNPs in the TP53 gene in AA and CA men and performed association analyses for functional TP53 SNPs with clinico-pathological features of CaP. The CPDR Oncoarray database on blood derived genomic DNA from 321 men treated by radical prostatectomy at WRNMMC were used to examine clini-co-pathological associations with TP53 SNPs. The SNP genotyping analysis on the final cohort of 308 patients (212 AA; 95 CA) identified 74 SNPs in the TP53 gene region with a minor allele fre-quency (MAF) of at least 1%. Two SNPs were non-synonymous in the exonic region of TP53: rs1800371 (Pro47Ser) and rs1042522 (Arg72Pro). The Pro47Ser variant, had a minor allele frequency of 0.01 in AA, however, was not detected in CA. Arg72Pro was the most common SNP with a minor allele frequency of 0.50 (0.41 in AA; 0.68 in CA). Additionally, Arg72Pro was associated with time to biochemical recurrence (BCR) after statistical adjustment for patient age at diagnosis, self-reported race, and Gleason score (p= 0.046; HR = 1.52). The present study demonstrated ancestral differences in allele frequencies of TP53 Arg72Pro and Pro47Ser SNPs in AA and CA CaP, providing a valuable framework for the interrogating CaP disparity among AA and CA men.

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The Role of p53 Family in Cancer

Abstract: This Special Issue covers a broad topic on the role of the p53 protein family in cancer [...]

Cited by 24 publications

References 15 publications

Genetic differences between smokers and never-smokers with lung cancer

Genetic differences between smokers and never-smokers with lung cancer

A comprehensive study of p53 protein

Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men

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