The Role of Paracetamol for Closing Patent Ductus Arteriosus. A Challenging Alternative for Ductal Closure?

Valera, Inés Tofé; Caballero, María Pilar Jaraba; González, María Dolores Ruiz; Benítez, María Victoria Rodríguez; Quiles, Marı́a José

doi:10.1016/j.rec.2016.05.013

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…[5][6][7] Furthermore, in different studies, the PDA closure rate of paracetamol was very variable, ranging between 20 and 100%. 5,[23][24][25][26][27] So far, the combination of NSAID and paracetamol has not been studied in preterm infants. In the pediatric population, no adverse effects or precautions were attributed to the combination of the two medications.…”

Section: Discussionmentioning

confidence: 99%

Adding Paracetamol to Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Hochwald

Mainzer²,

Borenstein-Levin

et al. 2018

Amer J Perinatol

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Section: Discussionmentioning

confidence: 99%

Adding Paracetamol to Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Hochwald

Mainzer²,

Borenstein-Levin

et al. 2018

Amer J Perinatol

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“…Four small case series have been performed by Tekgündüz et al [ 122 ], Memisoglu et al [ 118 ], Peňa-Juárez et al [ 123 ], and Tofé Valera et al [ 117 ] on 13, 11, 10, and 3 preterms, finding a hsPDA closure rate of 76.9%, 90,9%, 70%, and 100%, respectively, after paracetamol administration. Globally, hepatotoxicity (hypertransaminasemia) was described in two patients and no other significant side effects were detected.…”

Section: Discussion and Recent Literature Reviewmentioning

confidence: 99%

Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?

Bardanzellu

Neroni

Dessì

et al. 2017

BioMed Research International

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In preterm infants, failure or delay in spontaneous closure of Ductus Arteriosus (DA), resulting in the condition of Patent Ductus Arteriosus (PDA), represents a significant issue. A prolonged situation of PDA can be associated with several short- and long-term complications. Despite years of researches and clinical experience on PDA management, unresolved questions about the treatment and heterogeneity of clinical practices in different centers still remain, in particular regarding timing and modality of intervention. Nowadays, the most reasonable strategy seems to be reserving the treatment only to hemodynamically significant PDA. The first-line therapy is medical, and ibuprofen, related to several side effects especially in terms of nephrotoxicity, is the drug of choice. Administration of oral or intravenous paracetamol (acetaminophen) recently gained attention, appearing effective as traditional nonsteroidal anti-inflammatory drugs (NSAIDs) in PDA closure, with lower toxicity. The results of the studies analyzed in this review mostly support paracetamol efficacy in ductal closure, with inconstant low and transient elevation of liver enzymes as reported side effect. However, more studies are needed to confirm if this therapy shows a real safety profile and to evaluate its long-term outcomes, before considering paracetamol as first-choice drug in PDA treatment.

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Different approaches for patent ductus arteriosus in premature infants using acetaminophen

2022

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The Role of Paracetamol for Closing Patent Ductus Arteriosus. A Challenging Alternative for Ductal Closure?

Cited by 4 publications

References 6 publications

Adding Paracetamol to Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Adding Paracetamol to Ibuprofen for the Treatment of Patent Ductus Arteriosus in Preterm Infants: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?

Different approaches for patent ductus arteriosus in premature infants using acetaminophen

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