The role of Pavlovian cues in alcohol seeking in dependent and nondependent rats.

Glasner, Suzette; Overmier, J. Bruce; Balleine, Bernard W.

doi:10.15288/jsa.2005.66.53

Cited by 66 publications

(67 citation statements)

References 29 publications

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“…This was not true for the explicitly unpaired group animals where rates of drinker entries during the final session of Pavlovian conditioning were lower than pre-CS rates. This anticipatory CR may be reasonably interpreted as evidence of conditioned ethanol-seeking behavior (Corbit and Janak 2007;Glasner et al 2005;Krank 2003;Liu et al 2006;Tsiang and Janak 2006;Weerts et al 2006).…”

Section: Discussionmentioning

confidence: 91%

Goal- and signal-directed incentive: conditioned approach, seeking, and consumption established with unsweetened alcohol in rats

et al. 2007

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Section: Discussionmentioning

confidence: 91%

Goal- and signal-directed incentive: conditioned approach, seeking, and consumption established with unsweetened alcohol in rats

et al. 2007

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“…There is accumulating evidence that in substance dependence and disorders of compulsivity PIT effects are increased (Garbusow et al, , 2015Hogarth, Field, & Rose, 2013;Glasner, Overmier, & Balleine, 2005) whereas MB control appears to be disrupted Voon et al, 2014). Moreover, MB neural signatures are reduced in high-impulsive individuals (Deserno, Wilbertz, et al, 2015), and impulsivity further seems to be associated with PIT effects (Garofalo & di Pellegrino, 2015).…”

Section: Discussionmentioning

confidence: 99%

Don't Think, Just Feel the Music: Individuals with Strong Pavlovian-to-Instrumental Transfer Effects Rely Less on Model-based Reinforcement Learning

Sebold

Schad

Nebe

et al. 2016

Journal of Cognitive Neuroscience

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Behavioral choice can be characterized along two axes. One axis distinguishes reflexive, modelfree systems that slowly accumulate values through experience and a model-based system that uses knowledge to reason prospectively. The second axis distinguishes Pavlovian valuation of stimuli from instrumental valuation of actions or stimulus-action pairs. This results in four values and many possible interactions between them, with important consequences for accounts of individual variation. We here explored whether individual variation along one axis was related to individual variation along the other. Specifically, we asked whether individuals' balance between model-based and model-free learning was related to their tendency to show Pavlovian interferences with instrumental decisions. In two independent samples with a total of 243 participants, Pavlovian-instrumental transfer effects were negatively correlated with the strength of model-based reasoning in a two-step task. This suggests a potential common underlying substrate predisposing individuals to both have strong Pavlovian interference and be less model-based and provides a framework within which to interpret the observation of both effects in addiction. Abstract ■ Behavioral choice can be characterized along two axes. One axis distinguishes reflexive, model-free systems that slowly accumulate values through experience and a model-based system that uses knowledge to reason prospectively. The second axis distinguishes Pavlovian valuation of stimuli from instrumental valuation of actions or stimulus-action pairs. This results in four values and many possible interactions between them, with important consequences for accounts of individual variation. We here explored whether individual variation along one axis was related to individual variation along the other. Specifically, we asked whether individuals' balance between model-based and model-free learning was related to their tendency to show Pavlovian interferences with instrumental decisions. In two independent samples with a total of 243 participants, Pavlovianinstrumental transfer effects were negatively correlated with the strength of model-based reasoning in a two-step task. This suggests a potential common underlying substrate predisposing individuals to both have strong Pavlovian interference and be less model-based and provides a framework within which to interpret the observation of both effects in addiction. ■

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“…Studies on drug-and cue-induced reinstatement also indicate that these events trigger self-administration through somewhat separate processes (see Fuchs et al, 2008 for a recent review of this literature). It must be noted, however, that studies on cue-induced reinstatement rarely assess the impact of noncontingent presentations of separately trained drug-paired CSs on self-administration performance (but see Corbit et al, 2007;Glasner et al, 2005). Instead, such studies typically arrange for a response-cue relationship at test or deliver noncontingent presentations of a discriminative cue that has been explicitly associated with the self-administration response, making it impossible to determine whether the cue's ability to 'reinstate' responding is supported by its response-invigorating effects, its ability to support conditioned reinforcement, or through stimulus-response learning.…”

Section: Discussionmentioning

confidence: 99%

Dopamine Receptor Blockade Attenuates the General Incentive Motivational Effects of Noncontingently Delivered Rewards and Reward-Paired Cues Without Affecting Their Ability to Bias Action Selection

Ostlund¹,

Maidment²

2011

Neuropsychopharmacol

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Environmental cues affect our behavior in a variety of ways. Despite playing an invaluable role in guiding our daily activities, such cues also appear to trigger the harmful, compulsive behaviors that characterize addiction and other disorders of behavioral control. In instrumental conditioning, rewards and reward-paired cues bias action selection and invigorate reward-seeking behaviors, and appear to do so through distinct neurobehavioral processes. Although reward-paired cues are known to invigorate performance through a dopamine-dependent incentive motivational process, it is not known if dopamine also mediates the influence of rewards and rewardpaired cues over action selection. The current study contrasted the effects of systemic administration of the nonspecific dopamine receptor antagonist flupentixol on response invigoration and action bias in Pavlovian-instrumental transfer, a test of cue-elicited responding, and in instrumental reinstatement, a test of noncontingent reward-elicited responding. Hungry rats were trained on two different stimulus-outcome relationships (eg, tone-grain pellets and noise-sucrose solution) and two different action-outcome relationships (eg, left press-grain and right press-sucrose). At test, we found that flupentixol pretreatment blocked the response invigoration generated by the cues but spared their ability to bias action selection to favor the action whose outcome was signaled by the cue being presented. The response-biasing influence of noncontingent reward deliveries was also unaffected by flupentixol. Interestingly, although flupentixol had a modest effect on the immediate response invigoration produced by those rewards, it was particularly potent in countering the lingering enhancement of responding produced by multiple reward deliveries. These findings indicate that dopamine mediates the general incentive motivational effects of noncontingent rewards and reward-paired cues but does not support their ability to bias action selection.

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The role of Pavlovian cues in alcohol seeking in dependent and nondependent rats.

Cited by 66 publications

References 29 publications

Goal- and signal-directed incentive: conditioned approach, seeking, and consumption established with unsweetened alcohol in rats

Goal- and signal-directed incentive: conditioned approach, seeking, and consumption established with unsweetened alcohol in rats

Don't Think, Just Feel the Music: Individuals with Strong Pavlovian-to-Instrumental Transfer Effects Rely Less on Model-based Reinforcement Learning

Dopamine Receptor Blockade Attenuates the General Incentive Motivational Effects of Noncontingently Delivered Rewards and Reward-Paired Cues Without Affecting Their Ability to Bias Action Selection

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