Background: Along with economic crisis, the budget for research is also affected. Systematic review of outcome measurement instrument is a method for choosing researches and articles for our research and practice. It provides evidences to make sure that our research will useful. Besides that, economic evaluation is a new approach to help policy maker giving affordable decision to invest in health sector. Our purpose was defined and summarize the status of economic evaluations of vaccines and to find out the new trend in economic evaluation of vaccines in the future in Vietnam. Method: A systematic literature search was conducted in some database such as MEDLINE, SCOPUS, COCHRANCE and GOOGLE SCHOLAR between May 26th, 2016 and June 16th, 2016. The quality of reviews was assessed by using a specific checklist. Abstracts and titles are read firstly to eliminate articles are not related with our topic. Results: A total of six articles were included. These articles focus on three vaccines: rotavirus, typhoid VI and human papillomavirus vaccine. In there, only rotavirus vaccine is cost-effectiveness. The target population is children and women. These articles using mathematic model based on decision tree and Markov model are the method to approach. Conclusion: Economic evaluation is a new area in Vietnam, it need to pay attention to research and develop to control the investment effectively. It is important to be aware of methodology and interpretation of results because of affecting to decision of policy maker and also affecting in national expanded program in immunization on adding new good vaccines.