The role of peri‐device leak closure after left atrial appendage occlusion: A safe and feasible approach

Musumeci, Giuseppe; Civera, Stefania

doi:10.1002/ccd.29856

Cited by 1 publication

(2 citation statements)

References 5 publications

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“…Additionally, LAAC was shown to be noninferior to NOACs in preventing major AF-related cardiovascular, neurological, and bleeding events [6]. However, peri-device leaks (PDLs) are a common occurrence, with a 1-year rate ranging from 12.5% to 40% [7–9], varying between different devices [10]. The main cause of PDLs is a mismatch between the left atrial appendage and the closure device [11].…”

Section: Introductionmentioning

confidence: 99%

“…However, peri-device leaks (PDLs) are a common occurrence, with a 1-year rate ranging from 12.5% to 40% [7–9], varying between different devices [10]. The main cause of PDLs is a mismatch between the left atrial appendage and the closure device [11]. Although evidence suggests that patients in the ischaemic stroke/transient ischaemic attacks (TIAs)/systemic embolism (SE) group have a higher likelihood of PDL [12], the relationship between the occurrence of embolism events and PDL is still a topic of debate.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Peri-Device Leaks on Ischaemic Stroke/Transient Ischaemic Attack/Systemic Embolism after Left Atrial Appendage Closure: A Systematic Review and Meta-Analysis

He¹,

Yang²,

Xu³

et al. 2023

Cardiology

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Background: Left atrial appendage closure (LAAC) is a safe and effective method for preventing embolic events in patients with non-valvular atrial fibrillation. However, peri-device leaks (PDLs) are sometimes unavoidable. Controversy exists regarding whether PDLs lead to embolic events. Objectives: This study aimed to explore the association between PDLs and embolic events, including ischaemic stroke, transient ischaemic attacks (TIAs), and systemic embolism (SE). Methods: We conducted a systematic search of the PubMed, Web of Science, MEDLINE, and Cochrane Library databases for studies published up to September 25, 2022, to compare the rate of ischaemic stroke/TIA/SE between the PDL group and the non-PDL group after LAAC. Results: Thirteen studies comprising 54,405 patients were included in the meta-analysis. The PDL group detected by transoesophageal echocardiography (TEE) had a significantly higher rate of ischaemic stroke/TIA/SE than the non-PDL group (OR: 1.20, 95% CI: 1.08–1.33, p = 0.0009). However, no difference in ischaemic stroke/TIA/SE was found between the PDL and non-PDL subgroups of the cardiac computed tomography angiography (CCTA) group (OR: 1.12, 95% CI: 0.51–2.50, p = 0.77). CCTA and TEE showed different rates of PDL detection, with the CCTA group having a higher rate of PDL detection (p < 0.0001), especially for trivial leaks. Conclusions: PDL detected by TEE increases the risk of embolic events after LAAC. However, no association was found between PDL and ischaemic stroke/TIA/SE in the CCTA group, which showed a higher rate of PDL detection than TEE, particularly for trivial leaks. In the future, CCTA may be used to explore the relationship between PDL size and ischaemic stroke/TIA/SE.

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