The Role of Peyer's Patches in the Age-Related Incidence of Crohn's Disease

Kruiningen, Herbert J. Van; Ganley, Lorraine; Freda, Benjamin J.

doi:10.1097/00004836-199709000-00017

Cited by 50 publications

(47 citation statements)

References 32 publications

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“…19 We found that the lymphoid aggregate component of mucosa-associated lymphoid tissue is altered even in the uninvolved colorectal lining of inflammatory bowel diseases. Our finding supports a primary pathogenic involvement of the lymphoid aggregate system in Crohn's disease and in ulcerative colitis, since it suggests the presence of an altered mucosal substrate prone to extension or to relapse of the inflammatory disease.…”

Section: Discussionmentioning

confidence: 74%

Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

et al. 2005

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Section: Discussionmentioning

confidence: 74%

Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

et al. 2005

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“…A correlation exists between peak of CD case frequency (between 15 and 25 years old) and peak representing the number of PPs according to age, suggesting that CD develops as an inflammatory process specifically targeting these important lymphoid structures (36). Moreover, recent studies reported a defect in the intestinal barrier to control bacterial translocation across PPs of CD (37,38).…”

Section: Discussionmentioning

confidence: 99%

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

Chassaing¹,

Rolhion²,

Vallée³

et al. 2011

J. Clin. Invest.

221

203

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Crohn disease (CD) is a multifactorial disease in which an abnormal immune response in the gastrointestinal (GI) tract leads to chronic inflammation. The small intestine, particularly the ileum, of patients with CD is colonized by adherent-invasive E. coli (AIEC) -a pathogenic group of E. coli able to adhere to and invade intestinal epithelial cells. As the earliest inflammatory lesions are microscopic erosions of the epithelium lining the Peyer's patches (PPs), we investigated the ability of AIEC bacteria to interact with PPs and the virulence factors involved. We found that AIEC bacteria could interact with mouse and human PPs via long polar fimbriae (LPF). An LPF-negative AIEC mutant was highly impaired in its ability to interact with mouse and human PPs and to translocate across monolayers of M cells, specialized epithelial cells at the surface of PPs. The prevalence of AIEC strains harboring the lpf operon was markedly higher in CD patients compared with controls. In addition, increased numbers of AIEC, but not LPF-deficient AIEC, bacteria were found interacting with PPs from Nod2 -/-mice compared with WT mice. In conclusion, we have identified LPF as a key factor for AIEC to target PPs. This could be the missing link between AIEC colonization and the presence of early lesions in the PPs of CD patients.

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“…Although morbidity and mortality are relatively low, some types of disease show a peak incidence in the adolescent years. The highest incidence of hepatitis (/) and infections of the gastrointestinal tract (8) have been noted in the adolescent age range. The highest rate of near-fatal asthma attacks occurs in adolescence (9).…”

Section: Major Health Problems Of Adolescencementioning

confidence: 99%

Adolescent health and the environment.

Golub

2000

Environ Health Perspect

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The effects of toxicants depend on the dose and the time in the life span when exposure occurs. The biology of adolescence is distinctive and provides opportunities for unique actions of toXicants both in terns of disruption of function and disuption ofmaturation. Maturation ofa number of organ systems occurs during this period, induting not only the reproductive system but also the respiratory, skeletal, immune, and central nervous systems. Adolescence is a time of increased risk for infectious disease and accidental injury, making the effects of toxicants on the immune and central nervous systems particularly harmfil. Differences in blood volume, respiratory parameters, metabolic needs, and capacity all contribute to altered pharmacokinetics.Exposures can also change. Increased food intake associated with rapid adolescent growth alters exposure to food contaminants. Voluntary drug consumption increases, including drinking; smoking; substance abuse; and the use of over-the-counter, prescription, and performanceenhancing drugs. At the same time, adolescents are introduced to toxicants in the workplace.Basic research in the toxicology of adolescence needs to take into account the appropriateness of animal models for this distinctive human developmental stage; risk assessment must take into account pharmacokinetic and lifestyle factors. Screening methodologies that would identify toxic effects unique to adolescence would also be valuable.

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The Role of Peyer's Patches in the Age-Related Incidence of Crohn's Disease

Cited by 50 publications

References 32 publications

Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

Adolescent health and the environment.

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