The role of pH in the separation of Lu and Yb by ion-exchange explained by novel chemical structures of lanthanide complexes

Cáceres-Rivero, Cynthia; Ramos-Trujillo, Bertha Juli; Farfán, Yadberto; Solis, J. L.; Bedregal, Patricia

doi:10.1016/j.rechem.2022.100514

Cited by 5 publications

(2 citation statements)

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“…The final product contained less than 200 ng of Ho which was sufficient for labeling experiments performed. It is important to note that the efficiency of cation exchange resin is highly dependent on the correct preparation of NH 4 -α-HIB solution in terms of both concentration and pH. ,, A slight deviation from 70 mM concentration and 4.75 ± 0.05 pH can result in diminishing recovery of Er from resin or excess Ho contamination in the product of cation exchange resin. ,, …”

Section: Resultsmentioning

confidence: 99%

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er

Saghez,

Yang,

Radchenko

2024

Inorg. Chem.

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Introduction: Auger electron-emitting radionuclides with low (0.001−1 keV) energy, short-range (2−500 nm), and high linear energy transfer (4−26 keV/μm) can play an important role in the targeted radionuclide therapy (TRT) of cancer. 165 Er is a pure Auger electron-emitting radionuclide, making it a useful tool for the fundamental studies of the biological effects of Auger electrons. This work develops a simple, inexpensive, high separation factor, and high molar activity radiochemical isolation process for the production of 165 Er (t 1/2 10.36 h) suitable for TRT in vitro and in vivo studies using irradiated nat Ho solid targets. Methods: Small medical cyclotron proton-irradiation of nat Ho targets produced 165 Er in GBq scale quantities. 165 Er was isolated using cation exchange chromatographic resin (AG 50W-X8, 200− 400 mesh, 20 mL, under atmospheric pressure) using α-hydroxyisobutyric acid (70 mM, pH 4.75) followed by extraction using TK212, TK211, and TK221 extraction chromatographic columns. Radio nuclidic and chemical purity of the final 165 Er were confirmed using HPGe Gamma spectrometry and induction coupled plasma−mass spectrometry analysis, respectively. The purified 165 Er was radiolabeled with two radiometal chelators (DOTA and Crown) and used to produce a new Auger electron-emitting radiopharmaceutical, [ 165 Er]Er-Crown-TATE. Results: Irradiation of 200 mg nat Ho targets with 20−30 μA of 12.8 MeV protons produced 165 Er at 25 ± 5 MBq•μA −1 •h −1 . The 4.5 ± 0.5 h radiochemical isolation yielded GBq scale of 165 Er in 0.05 M HCl (2 mL) with a radiochemical yield of 78.0 ± 5.6% decay corrected to the end of bombardment (EoB) and a Ho/ 165 Er separation factor of (1.14 ± 0.25) × 10 6 . The product showed high radio nuclidic purity and chemical purity. Concentration-dependent radiolabeling experiments with Crown and DOTA were performed resulting in the successful labeling of 165 Er with high (>90%) radiochemical yield. Radiolabeling experiments with Crown-TATE were performed 8 h after EoB and synthesized [ 165 Er]Er-Crown-TATE at molar activities of 202.4 MBq•nmol −1 at the end of synthesis (EoS). Conclusions: A 3 h cyclotron irradiation and 4.5 h radiochemical separation produced GBq-scale 165 Er suitable for producing radiopharmaceuticals at molar activities satisfactory for investigations of targeted radionuclide therapeutic effects of Auger electron emissions. This will enable future fundamental radiation biology experiments of pure Auger electron-emitting therapeutic radiopharmaceuticals, such as [ 165 Er]Er-Crown-TATE, which will be used to understand the impact of Auger electrons in TRT.

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Section: Resultsmentioning

confidence: 99%

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er

Saghez,

Yang,

Radchenko

2024

Inorg. Chem.

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“…The lanthanides (Ln), naturally existing minerals also known as rare earths (REs) or rare earth elements (REEs), are isolated from their ores by various processes such as acidic (hydrochloric acid, sulfuric acid) and basic (sodium hydroxide) treatments, ion exchange, and solvent extraction techniques. 22 These are categorized as group 3 elements having a unique feature of "lanthanide contraction" that inculcates these trivalent cations with increased hydration enthalpies, which enabled them to form bonds with strongly coordinating ligands. Moreover, these elements have distinctive mechanical, magnetic, photogenic, and nuclear properties.…”

Section: ■ Why Lanthanidesmentioning

confidence: 99%

Lanthanides: The Key to Durable and Sustainable Corrosion Protection

Zehra

Kaseem

2023

ACS Sustainable Chem. Eng.

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Amide-decorated reusable C18 silica-packed columns for the rapid, efficient and sequential separation of lanthanoids using reversed phase-high performance liquid chromatography

Kongasseri,

Madhesan,

Krishna Kumar

et al. 2024

Journal of Chromatography A

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The role of pH in the separation of Lu and Yb by ion-exchange explained by novel chemical structures of lanthanide complexes

Cited by 5 publications

References 32 publications

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er

Lanthanides: The Key to Durable and Sustainable Corrosion Protection

Amide-decorated reusable C18 silica-packed columns for the rapid, efficient and sequential separation of lanthanoids using reversed phase-high performance liquid chromatography

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The role of pH in the separation of Lu and Yb by ion-exchange explained by novel chemical structures of lanthanide complexes

Cited by 5 publications

References 32 publications

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure 165Er

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure 165Er

Lanthanides: The Key to Durable and Sustainable Corrosion Protection

Amide-decorated reusable C18 silica-packed columns for the rapid, efficient and sequential separation of lanthanoids using reversed phase-high performance liquid chromatography

Contact Info

Product

Resources

About

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er

High Separation Factor, High Molar Activity, and Inexpensive Purification Method for the Production of Pure ¹⁶⁵Er