The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe, 167-172

Bramness, Jørgen G.; Buajordet, Ingebjørg

doi:10.5324/nje.v18i2.29

Cited by 7 publications

(9 citation statements)

References 45 publications

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“…Carisoprodol has a great ability to change due to its aptitude to potentiate the effects of other illegal drugs [10] . High dosage of carisoprodol led to symptoms of tolerance, dependence and withdrawal in humans [11] . Drug Enforcement Administration (DEA) [12] showed that carisoprodol abuse has expanded in the last decade in the United States.…”

Section: Introductionmentioning

confidence: 99%

Carisoprodol (Somadril) induced histological and histochemical changes in renal cortex of pregnant rats and their fetuses

Abdelhafez

Rabou

2019

Egyptian Journal of Histology

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Background: Carisoprodol is a generally prescribed skeletal muscle relaxant whose primary active metabolite is meprobamate, a substance with well-established abuse potential similar to that of benzodiazepines. A number of reports showed that carisoprodol has been abused for its anodyne and relaxant effects. Aim: The diversion and misuse of carisoprodol and its adverse health effects appeared to be dramatically increased over the last several years. This study aimed to detect the histological and histochemical changes in the cortex of renal tissue of pregnant rats and their fetuses after treatment with carisoprodol. Materials and Methods: Thirty pregnant female rats were randomly categorized into three groups (ten pregnant female rats in each group). The first was administered oral doses of distilled water and served as control. The other two groups were administered oral doses of carisoprodol (Somadril compound) in the distilled water equivalent to 10.8 and 21.6 mg/100g body weight/day respectively for 15 days from the 6 th day to the 20 th day of gestation. Results: Maternal and fetal renal cortex tissue of both treated groups showed lots of degenerative changes post-treatment with carisoprodol. The severity of these changes was more obvious in fetal cortex of renal tissue of both groups this was accompanied with numerous histochemical changes. Conclusion: Treatment of pregnant rats with carisoprodol led to numerous dystrophic changes in the maternal and fetal renal cortex tissue. These findings provide evidence to support current recommendations to avoid the use of carisoprodol in pregnant rats except if the potential benefit justifies the risk to the fetuses.

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Section: Introductionmentioning

confidence: 99%

Carisoprodol (Somadril) induced histological and histochemical changes in renal cortex of pregnant rats and their fetuses

Abdelhafez

Rabou

2019

Egyptian Journal of Histology

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“…Based on both these and other publications [21], a debate on the risk ⁄ benefit ratio for carisoprodol began in Norway [22]. It was concluded that the possibility of both abuse and serious intoxications made this ratio too high and that other available drugs could be considered as satisfactory alternatives.…”

mentioning

confidence: 99%

The Effect of Scheduling and Withdrawal of Carisoprodol on Prevalence of Intoxications with the Drug

Høiseth

Karinen

Sørlid

et al. 2009

Basic Clin Pharma Tox

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The centrally acting muscle relaxant carisoprodol has previously been shown to cause psychomotor impairment and to have a narrow therapeutic range. In Norway, carisoprodol was therefore reclassified to the highest scheduling level During the same period, the sales figures for carisoprodol decreased dramatically, and we observed a relation between the numbers of DUI cases, forensic autopsies and contacts to the NPIC concerning carisoprodol and the sales figures for the drug. This study showed that the rescheduling and withdrawal of carisoprodol from the Norwegian market had a positive effect on the prevalence of carisoprodol in impaired driving, deaths and contacts regarding intoxications. This, together with previous publications, indicates that the population reflected in our data uses regularly prescribed carisoprodol and, to a lesser degree, drug from an illegal street market.

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“…Carisoprodol is a centrally acting muscle relaxant, it with a high abuse potential leading to central nervous system depression and may result in symptoms that are more difficult for providers to treat (Kathy et al 2017). Moreover, carisoprodol drug is available as somadril compound which contains paracetamol 160mg, caffeine 32mg and carisoprodol 200mg (Bramness et al 2008). The drug is found in markets by a diversity names (Soma, Sodol, Somalgit, Vanadam, Sonoma, Scutamil, Carisoma, Somacid, Mio Relax, Relacton-C, Relaxibys, Rela and Soridol) as reported with Reeves et al (2012).…”

Section: Introductionmentioning

confidence: 99%

Maternal and Fetal Toxicity of Carisoprodol Drug (Somadril Compound) on Pulmonary Tissues of Albino Rats

Emam

2019

JBLS

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Carisoprodol is a common muscle relaxant indicated as adjunctive therapy in acute, painful musculoskeletal cases. This current study aimed to investigate the histopathological, histochemical and immunohistochemical effects in the lung tissue of the pregnant rats and their fetuses after carisoprodol treatment. The present study was applied on twenty seven pregnant female rats and they were randomly divided into three groups (nine pregnant female rats in each group). Rats of the first (control) group were administered oral doses of distilled water. Rats of the second (S1) and third groups (S2) were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for fifteen days from the six to the twenty day of gestation. Several histopathological, histochemical and some immunohistochemical changes were studied to detect the pathological changes. Maternal and fetal pulmonary tissues of both treated groups showed numerous degenerative changes post-treatment with carisoprodol, the severity of these changes was more obvious in the fetal lung tissue of both groups. Also, carisoprodol treated rats showed a marked increase in caspase-3 content in the maternal and fetal pulmonary tissues. Treatment of pregnant rats with carisoprodol drug led to numerous dystrophic changes in both maternal and fetal lung tissues.

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The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe, 167-172

Cited by 7 publications

References 45 publications

Carisoprodol (Somadril) induced histological and histochemical changes in renal cortex of pregnant rats and their fetuses

Carisoprodol (Somadril) induced histological and histochemical changes in renal cortex of pregnant rats and their fetuses

The Effect of Scheduling and Withdrawal of Carisoprodol on Prevalence of Intoxications with the Drug

Maternal and Fetal Toxicity of Carisoprodol Drug (Somadril Compound) on Pulmonary Tissues of Albino Rats

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