The role of phosphatidylcholine 34:1 in the occurrence, development and treatment of ulcerative colitis

Yu, Tengjie; Zhou, Zhihao; Liu, Shijia; Li, Changjian; Zhang, Zhiwei; Zhang, Yong; Jin, Wanqin; Liu, Keanqi; Mao, Shuying; Zhu, Lei; Xie, Lihua; Wang, Guangji; Liang, Yan

doi:10.1016/j.apsb.2022.09.006

Cited by 13 publications

(6 citation statements)

References 53 publications

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“…In vivo and in vitro studies have shown that LysoPC can induce the release of pro‐inflammatory cytokines and disrupt the epithelial barrier (Tang et al., 2021). A study revealed a significant reduction in the level of PC lipids in colon organoids of mice with UC, which was found to be closely associated with the progression of the disease (Yu et al., 2023b). Moreover, research has shown that taurocholic acid can lead to the production of hydrogen sulfide and deoxycholic acid, which are genotoxic compounds that can damage intestinal health and even initiate tumors (Ridlon et al., 2016).…”

Section: Resultsmentioning

confidence: 99%

Wallace melon juice fermented with Lactobacillus alleviates dextran sulfate sodium‐induced ulcerative colitis in mice through modulating gut microbiota and the metabolism

Zhang,

Zhong,

Wang

et al. 2024

Journal of Food Science

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Fermented foods have shown promise in preventing or treating ulcerative colitis (UC) via regulating intestinal flora and correcting metabolic disorders. However, the prevention effect of fermented Wallace melon juice (FMJ) on UC is unclear. In this study, the effects of FMJ on dextran sodium sulfate (DSS)‐induced UC were investigated via 16S rRNA sequencing and non‐targeted metabolomics. The results showed that FMJ was effective in alleviating the symptoms of UC, reducing histological damage and oxidative stress, decreasing the levels of pro‐inflammatory cytokines. After FMJ treatment, the level of propionic acid, butyric acid, and valeric acid increased by 14.1%, 44.4%, and 52.4% compared to DSS‐induced UC mice. Meanwhile, the levels of harmful bacteria such as Oscillospira, Bacteroidetes, and Erysipelotrichaceae and Clostridium decreased, while the levels of beneficial bacteria such as Akkermansia, Lactobacillus, and Bifidobacterium increased. Fecal metabolomics analysis identified 31 differential metabolites, which could regulate metabolic disorders in UC mice by controlling the primary bile acid biosynthesis, purine metabolism, and pantothenate and CoA biosynthesis pathway. Additionally, the abundances of butyric acid, bile acids, and pantothenic acid were positively correlated with Allobaculum, Bifidobacterium, and other beneficial bacteria (R2 > 0.80, p < 0.01). The results indicated that FMJ played a role in regulating the structure of intestinal flora, which in turn helped in repairing metabolic disorders and alleviated colitis inflammation.

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Section: Resultsmentioning

confidence: 99%

Wallace melon juice fermented with Lactobacillus alleviates dextran sulfate sodium‐induced ulcerative colitis in mice through modulating gut microbiota and the metabolism

Zhang,

Zhong,

Wang

et al. 2024

Journal of Food Science

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“…Phosphatidylcholines have previously been reported to be decreased in the intestinal mucus of patients with ulcerative colitis 55 , 56 . Both upregulation of phosphatidylcholine hydrolyzing enzyme phospholipase A2 and downregulation of phosphatidylcholine synthase have been documented in human patients and rodent models of IBD and were proposed to be underlying mechanisms of phosphatidylcholine-deficiency 57 , 58 . Supplementation of phosphatidylcholine in humans has been shown to have anti-inflammatory effects in patients with IBD 51 , 59 and improve clinical and endoscopic outcomes, histologic activity, and quality of life in patients with ulcerative colitis 59 , 60 .…”

Section: Discussionmentioning

confidence: 99%

Unbiased serum metabolomic analysis in cats with naturally occurring chronic enteropathies before and after medical intervention

Questa,

Weimer,

Fiehn

et al. 2024

Sci Rep

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Chronic enteropathies (CE) are common disorders in cats and the differentiation between the two main underlying diseases, inflammatory bowel disease (IBD) and low-grade intestinal T-cell lymphoma (LGITL), can be challenging. Characterization of the serum metabolome could provide further information on alterations of disease-associated metabolic pathways and may identify diagnostic or therapeutic targets. Unbiased metabolomics analysis of serum from 28 cats with CE (14 cats with IBD, 14 cats with LGITL) and 14 healthy controls identified 1,007 named metabolites, of which 129 were significantly different in cats with CE compared to healthy controls at baseline. Random Forest analysis revealed a predictive accuracy of 90% for differentiating controls from cats with chronic enteropathy. Metabolic pathways found to be significantly altered included phospholipids, amino acids, thiamine, and tryptophan metabolism. Several metabolites were found to be significantly different between cats with IBD versus LGITL, including several sphingolipids, phosphatidylcholine 40:7, uridine, pinitol, 3,4-dihydroxybenzoic acid, and glucuronic acid. However, random forest analysis revealed a poor group predictive accuracy of 60% for the differentiation of IBD from LGITL. Of 129 compounds found to be significantly different between healthy cats and cats with CE at baseline, 58 remained different following treatment.

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“…The metabolic profiles of serum, urine, gut tissues and faecal extracts have been measured in mouse models of ulcerative colitis and patients in previous studies ( Schicho et al, 2010 ; Le Gall et al, 2011 ; Zhang et al, 2013 ). Alterations in lipids (cholesterol, triglycerides, phospholipids and fatty acids), amino acids (tryptophan, phenylalanine, glutamic acid, glutamine, methionine, and homocysteine), ketone bodies (3-hydroxybutyrate), energy metabolites (lactate, pyruvate and metabolites in the TCA cycle), and purines and pyrimidines have been observed in ulcerative colitis ( Shiomi et al, 2011 ; De Preter, 2015 ; LINS et al, 2020 ; Aldars-Garcia et al, 2021 ; Kang et al, 2022 ; Yu et al, 2022 ). In this study, we measured the metabolites in the serum, colon tissue, gut contents and faeces of the colitis mouse model using a UPLC-TOF/MS-based untargeted metabolomics method.…”

Section: Discussionmentioning

confidence: 99%

Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota

et al. 2023

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Introduction: Polysaccharides from Grifola frondosa (Dicks.) Gray (HSH) and Inonotus obliquus (Fr.) Pilat (BHR) showed noticeable effects on dextran sulfate sodium (DSS)-induced colitis, but their systemic modulation effects have not been fully revealed. This study aimed to investigate the regulation of the gut microbiota and systemic metabolism by HSH and BHR in DSS-induced colitis.Methods: C57BL/6J mice were given DSS (2.5%) in water and were treated with HSH and BHR (200 mg/kg/day) by gavage. Body weight and colon length were recorded, and H&E and AB-PAS staining of the colon were conducted to evaluate the model and the protective effect of the polysaccharides. Additionally, an LC-QTOF/MS-based untargeted metabolomic platform was used to identify the metabolites in the serum, colon tissue, gut contents, and faeces and investigate differential metabolites and metabolic pathways. 16S rDNA gene sequencing was used to measure the composition of bacterial communities.Results: The results showed that the mouse colitis model was established successfully, as evidenced by an increased disease activity index score [2.83 ± 0.62 vs. 0.06 ± 0.14 (p < 0.001)] and shortened colon length [5.43 ± 0.64 cm vs. 7.04 ± 0.29 cm (p < 0.001)], and HSH and BHR ameliorated DSS-induced colitis by improving the disease activity index (2.17 ± 0.28 and 1.83 ± 0.29, respectively) and restoring the colon length (6.12 ± 0.30 cm and 6.62 ± 0.35 cm, respectively). HSH and BHR significantly modulated metabolites involved in aromatic amino acid metabolism, the citrate cycle, purine metabolism, pyrimidine metabolism, etc. HSH and BHR increased the Chao1 index by 64.25% and 60.25%, respectively, and they increased the Shannon index by 13.02% and 10.23%, respectively. They both reversed the increase in the abundances of g_Odoribacter, g_Clostridium, g_AF12, g_Parabacteroides and g_Turicibacter and reversed the decrease in the abundance of g_unclassified_Bacteria induced by DSS. Specifically, HSH reversed the reductions in g_unclassified_Lactobacillales and g_Ruminococcus, and BHR reversed the decreases in g_unidentified_Coriobacteriaceae and g_unclassified_Firmicutes.Discussion: These results suggested that HSH and BHR may ameliorate DSS-induced colitis by global modulation of systemic metabolism and the gut microbiota. Targeting the gut microbiota may be a potentially effective strategy to modulate systemic metabolism and treat colitis.

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The role of phosphatidylcholine 34:1 in the occurrence, development and treatment of ulcerative colitis

Cited by 13 publications

References 53 publications

Wallace melon juice fermented with Lactobacillus alleviates dextran sulfate sodium‐induced ulcerative colitis in mice through modulating gut microbiota and the metabolism

Wallace melon juice fermented with Lactobacillus alleviates dextran sulfate sodium‐induced ulcerative colitis in mice through modulating gut microbiota and the metabolism

Unbiased serum metabolomic analysis in cats with naturally occurring chronic enteropathies before and after medical intervention

Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota

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