The Role of Phosphodiesterase Type 5 Inhibitors in the Management of Premature Ejaculation: A Critical Analysis of Basic Science and Clinical Data

Chen, Juza; Keren-Paz, Gal; Bar-Yosef, Yuval; Matzkin, Haim

doi:10.1016/j.eururo.2007.08.005

Cited by 44 publications

(45 citation statements)

References 54 publications

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“…6 Although the measurement of IELT by a stopwatch is the most accepted tool and considered to be objective, many authors find this modality to be controversial; first, due to the inconvenience of the use of a stopwatch during intercourse, second, because it may decrease the quality of the sexual intercourse and third, because it may not be acceptable to all patients or their sexual partners. 4 In addition, IELT may not categorize patients adequately because some patients with a brief IELT, report little or no bother and yet others with an IELT of several minutes may report bother with ejaculating prematurely. The International Society for Sexual Medicine (ISSM) convened a meeting on October 2007 and defined life-long PE as 'a male sexual dysfunction characterized by ejaculation which always or nearly always occurs before or within about one minute of vaginal penetration; and, inability to delay ejaculation on all or nearly all vaginal penetrations; and, negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy'.…”

Section: Discussionmentioning

confidence: 99%

“…In their article, reviewing the role of phosphodiesterase type 5 inhibitors in the management of PE, Chen et al 4 pointed to the need of developing new, convenient and efficient technology to measure IELT, which will be less dependent on the attention of the sexual partners as well as to carry out studies to evaluate the correlation between stopwatches measured IELT and existing questionnaires. Therefore, we evaluated the association of PEDT with IELT.…”

Section: Discussionmentioning

confidence: 99%

“…3 Second, the currently available IELT measurement method of using a stopwatch is not ideal because inherent subjective difficulties in measurement can cause bias in the evaluation of the results. 4 A brief self-administered questionnaire, the premature ejaculation diagnostic tool (PEDT), was developed and validated by Symonds et al 5 to standardize the diagnosis of PE in clinical trials. Although the PEDT has been validated rigorously and can be easily administered to facilitate the diagnosis of PE, use in other cultures should involve further validation to ensure appropriateness.…”

Section: Introductionmentioning

confidence: 99%

“…4 Thus, the purpose of this study was to carry out the Turkish validation of the PEDT and to evaluate its association with IELT.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Şerefoğlu¹,

Çimen²,

Özdemır³

et al. 2008

Int J Impot Res

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There are uncertain issues on the diagnostic methods of premature ejaculation (PE). The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria in diagnosing PE and the aim of this study is to carry out the Turkish validation of the PEDT and to evaluate its association with intravaginal ejaculatory latency time (IELT). A total of 94 patients with a self-reported complaint of PE and 88 men without PE were enrolled into the study and requested to complete the nine-item PEDT, which was translated into Turkish. The patients were also requested to measure IELT. All participants were requested to come for a second visit to assess the PEDT's retest reliability; data from 78 men in the PE group and 69 men in the control group were collected. The IELT data of 35 patients were also recorded. The mean age of the PE group and the control group were 39.4±9.7 (24-65) and 30.1±5.7 (20-56), respectively, (P ¼ 0.068). Among the patients in the PE group, 24 (68.5%) reported life-long PE, whereas 11 (31.5%) reported acquired PE. The geometric mean IELT of the PE group was 59.7 ± 46.2 (6.5-197.7) s. The number of men reporting IELTs of o1, 1-o2 and 42 min were 20 (57.1%), 11 (31.5) and 4 (11.4%), respectively. The factor analysis assessment showed that the five-item combination (questions 1, 2, 3, 4 and 8) explained 74.4% of the variance, there were no other combinations that explained the variance more effectively. Cronbach's alpha score of five-item combination was calculated as 0.77, showing adequate internal consistency. The overall Cronbach's alpha score did not increase if any item combination was deleted. The test-retest correlation coefficients of each item were higher than 0.80 and the correlation coefficient of the total score was 0.90. The PEDT and IELT showed an adequate correlation (q ¼ 0.44). As a conclusion, the validated five-item Turkish version of PEDT is a reliable questionnaire to screen PE among Turkish patients. Its significant association with IELT supports the fact that PEDT may be of benefit for the diagnosis of PE and measuring the response to treatment. In addition, PEDT seems to be more applicable than measuring IELT in our population, for the assessment of PE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…4 Thus, the purpose of this study was to carry out the Turkish validation of the PEDT and to evaluate its association with IELT.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Şerefoğlu¹,

Çimen²,

Özdemır³

et al. 2008

Int J Impot Res

View full text Add to dashboard Cite

show abstract

“…Sildenafil PDE5 inhibisyonu ile cGMP derişimini yükselterek korpus kavernosum düz kasında gevşemeye neden olur ve ereksiyonun sürdürülmesini sağlar (Bilge ve ark., 2005). Klinik araştırmalarda sildenafilin, PE'nin tedavisinde SSRI'ların ejakülasyon geciktirici etkisini artırmak amacı ile de kullanılabileceği bildirilmektedir (Rosen ve ark., 1999;Chen, 2007). Fakat bununla çelişen şekilde; sildenafilin SSRI kullanımına bağlı olarak oluşan gecikmiş ejakülasyonun tedavisinde de yararlı olabileceği öne sürülmektedir (Damis ve ark., 1999;Nurnberg, 2001;Seidman, 2006).…”

Section: Introductionunclassified