The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease

Slatopolsky, Eduardo; Bricker, Neal S.

doi:10.1038/ki.1973.92

Cited by 228 publications

(88 citation statements)

References 17 publications

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“…It triggers parathyroid hyperplasia, secondary hyperpapathyroidism, metastatic calcification and is now recognised to significantly influence mortality in CRF patients. 13,[23][24][25] This Even though, only a small percentage of the patients had assays of intact parathormone (PTH), active Vitamin D and osteocalcin done, secondary hyperparathyroidism was detected in only 18%, this is in sharp contrast to the findings in Benin where osteitis fibrosa was found in 9 of the 10 bone biopsies performed though serum PTH was not assayed. The pattern of renal bone disease is changing worldwide with the prevalence of hyperparathyroid bone disease and consequent osteitis fibrosa declining while that of low turnover or adynamic bone disease is increasing.…”

Section: Discussioncontrasting

confidence: 49%

Prevalence and Pattern of Renal Bone Disease in End Stage Renal Disease Patients in Ile-Ife, Nigeria

Sanusi

Arogundade²,

Oladigbo³

et al. 2011

West African Journal of Medicine

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Section: Discussioncontrasting

confidence: 49%

Prevalence and Pattern of Renal Bone Disease in End Stage Renal Disease Patients in Ile-Ife, Nigeria

Sanusi

Arogundade²,

Oladigbo³

et al. 2011

West African Journal of Medicine

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“…É possível que pequenas oscilações nas concentrações séricas de cálcio ou de fósforo em cães com IRC sejam suficientes para promover a hipersecreção de PTH (Slatopolsky e Bricker, 1973). Apenas um dos cães com IRC apresentou concentração sérica de PTHi menor do que 126pg/ml, valor considerado normal (igual ao dos cães do grupocontrole) e, simultaneamente, valores elevados de fósforo e cálcio, o que pode indicar a capacidade de resposta da paratireóide ao mecanismo feed back à normo ou hipercalcemia (Torrance e Nachreiner, 1989b ).…”

Section: Discussionunclassified

Concentração sérica de paratormônio intacto em cães com insuficiência renal crônica

Lazaretti¹,

Kogika

Hagiwara

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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RESUMOEstudou-se a ocorrência de hiperparatireoidismo secundário renal e determinaram-se as concentrações séricas de paratormônio intacto (PTHi-c), cálcio total e fósforo em 30 cães com insuficiência renal crônica (IRC) e em 40 cães sadios. Para a determinação do PTHi-c, foi utilizado o método imunofluorométrico, com o emprego de anticorpos anti-aminoterminal (extraídos de gema de ovo da galinha) e de anticorpos monoclonais anti-carboxiterminal (H5P10), marcados com Europium. As concentrações séricas de PTHi-c (717,23±469,13pg/ml no grupo IRC e 36,76±34,40pg/ml no grupocontrole; P=0,0001), cálcio total (11,46±2,03mg/dl no grupo IRC e 10,11±0,91mg/dl no grupo-controle; P=0,003) e fósforo (12,01±8,06mg/dl no grupo IRC e 4,33±0,74mg/dl no grupo-controle; P=0,0001) foram mais altas nos cães com IRC. Observou-se estreita correlação entre PTHi-c e fósforo (r=0,56; P=0,0006), o que não ocorreu entre PTHi-c e cálcio. Hipercalcemia em cães com alta concentração de PTHi-c demonstrou a possível ocorrência de hiperparatireoidismo terciário em 11 animais. A hiperfosfatemia pode indicar, de forma indireta, a ocorrência de hiperparatireoidismo secundário nos cães com IRC. Palavras-chave: cão, insuficiência renal crônica, cálcio, fósforo, paratormônio ; for total calcium it was 11.46±2.03mg/dl in CRF group and 10.11±0.91mg/dl in control group (P=0.003); and for phosphorus it was 12.01±8.06mg/dl in CRF group and 4.33±0.74mg/dl in control group (P=0.0001 ABSTRACT The occurrence of renal secondary hyperparathyroidism was studied and serum intact parathormone (PTHi-c), total calcium and phosphorus were measured in thirty dogs with chronic renal failure (CRF) and in forty healthy dogs. The imunnofluorometric method was used for the PTHi-c assay, using antiaminoterminal antibodies (obtained from chicken yolk) and anti-carboxiterminal monoclonal antibodies (H5P10), marked with Europium. Mean value ± SD of serum concentration of

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“…Inadequate calcium absorption prompts adaptive responses by the parathyroid glands to maintain blood ionized calcium concentrations (38). FGF-23 thus adds a new dimension to the well-known 25-year-old trade-off theory, according to which hyperparathyroidism is the price to pay for preventing hyperphosphatemia and hypocalcemia (39).…”

Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor-23 in Early Chronic Kidney Disease

Evenepoel¹,

Meijers²,

Viaene³

et al. 2010

Clinical Journal of the American Society of Nephrology

105

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The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease

Cited by 228 publications

References 17 publications

Prevalence and Pattern of Renal Bone Disease in End Stage Renal Disease Patients in Ile-Ife, Nigeria

Prevalence and Pattern of Renal Bone Disease in End Stage Renal Disease Patients in Ile-Ife, Nigeria

Concentração sérica de paratormônio intacto em cães com insuficiência renal crônica

Fibroblast Growth Factor-23 in Early Chronic Kidney Disease

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