The role of photodynamic therapy in breast cancer – A review of in vitro research

Czarnecka-Czapczyńska, Magdalena; Aebisher, David; Oleś, Piotr; Sosna, Barbara; Krupka-Olek, Magdalena; Dynarowicz, Klaudia; Latos, Wojciech; Cieślar, Grzegorz; Kawczyk‐Krupka, Aleksandra

doi:10.1016/j.biopha.2021.112342

Cited by 22 publications

(7 citation statements)

References 94 publications

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“…At 0.1 μM TT1 still 30.5 % cell‐killing was observed (Figure 4A). Noteworthy, the effective doses of TT1 in this study were in a sub‐micromolar range even though cells were treated only for a relatively short time (1.5 hours) compared to other reported systems, [24] demonstrating the benefit of active targeting by 7D12. Subsequently, the activities of NP3 and NP4 were compared (Figure 4B).…”

Section: Resultsmentioning

confidence: 76%

Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration

İbrahimova

et al. 2023

Angew Chem Int Ed

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We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock ELP conjugates. Methionine residues in this monoblock are photo-oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π-π stacking, inducing the re-formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of "smart" nanomedicines with deeper penetration capacity for effective anticancer therapies.

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Section: Resultsmentioning

confidence: 76%

Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration

İbrahimova

et al. 2023

Angew Chem Int Ed

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“…Overview of Photodynamic therapy. Photodynamic therapy (PDT) is a cancer treatment technology that employs a specific wavelength of light (600−800 nm) to activate the photosensitizer in target tissues, resulting in the generation of reactive oxygen species (ROS) such as singlet oxygen, 6 hydrogen peroxide, and hydroxyl radicals. Reactive oxygen kills tumor cells by inducing apoptosis, necrosis, or autophagy.…”

Section: Applications Of Ce6 In Photodynamic Therapymentioning

confidence: 99%

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

et al. 2023

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Chlorin e6 (Ce6) has been extensively researched and developed as an antitumor therapy. Ce6 is a highly effective photosensitizer and sonosensitizer with promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and light therapy for tumors. Ce6 is also being studied for other applications in fluorescence navigation, antibacterials, and plant growth regulation. Here we review the role and research status of Ce6 in tumor therapy and the problems and challenges of its clinical application. Other biomedical effects of Ce6 are also briefly discussed. Despite the difficulties in clinical application, Ce6 has significant advantages in photodynamic therapy (PDT)/sonodynamic therapy (SDT) against cancer and offers several possibilities in clinical utility.

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“…Singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (·OH) are the main components of ROS. Reactive oxygen species produce cytotoxic effects, leading to cell damage and even death [ 9 , 10 ]. SDT shares similarities in mechanism with PDT, but it uses acoustic energy rather than light energy.…”

Section: Overview Of Sdtmentioning

confidence: 99%

Ultrasound Sonosensitizers for Tumor Sonodynamic Therapy and Imaging: A New Direction with Clinical Translation

Liang,

Zhang,

Zhang

et al. 2023

Molecules

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With the rapid development of sonodynamic therapy (SDT), sonosensitizers have evolved from traditional treatments to comprehensive diagnostics and therapies. Sonosensitizers play a crucial role in the integration of ultrasound imaging (USI), X-ray computed tomography (CT), and magnetic resonance imaging (MRI) diagnostics while also playing a therapeutic role. This review was based on recent articles on multifunctional sonosensitizers that were used in SDT for the treatment of cancer and have the potential for clinical USI, CT, and MRI applications. Next, some of the shortcomings of the clinical examination and the results of sonosensitizers in animal imaging were described. Finally, this paper attempted to inform the future development of sonosensitizers in the field of integrative diagnostics and therapeutics and to point out current problems and prospects for their application.

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The role of photodynamic therapy in breast cancer – A review of in vitro research

Cited by 22 publications

References 94 publications

Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration

Light‐Responsive Elastin‐Like Peptide‐Based Targeted Nanoparticles for Enhanced Spheroid Penetration

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

Ultrasound Sonosensitizers for Tumor Sonodynamic Therapy and Imaging: A New Direction with Clinical Translation

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