The role of photoperiod on the expression of hypothalamic genes regulating appetite in Chevrier’s field mouse (Apodemus chevrieri)

Lin, Zhihong; Yang, Fang; Cai, Jinhong; Huang, C. C.; Wang, Zhengkun; Zhu, Weiming

doi:10.1163/15707563-00002460

Cited by 2 publications

(3 citation statements)

References 52 publications

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“…AgRP mRNA expression was significantly increased in L. brandtii 69 , (3). NPY mRNA expression was significantly increased in A. chevrieri 40 , and (4). on changes in all gene mRNA expression in Cricetulus barabensis 70 .…”

Section: Discussionmentioning

confidence: 99%

“…orexigenic neuropeptides (neuropeptide Y: NPY, and agouti-related protein: AgRP). The balance between these four neuropeptides can inhibit food intake and stimulate energy expenditure: by stimulating NPY/AgRp-expression and suppression POMC/CART-expression, the food intake increased and energy expenditure decreased 39 , such as Apodemus chevrieri 40 and Eothenomys oliter 23 , and the mRNA levels appear in seasonal cycles, such as E. oliter , the NPY/AgRp mRNA level appear the peak and bottom at winter and summer, respectively, however, the POMC/CART mRNA level appear an opposite trand 23 .…”

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confidence: 99%

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Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Lin

Yang

Wang

et al. 2017

Sci Rep

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Ambient conditions, as temperature and photoperiod, play a key role in animals' physiology and behaviors. To test the hypothesis that the maximum thermal physiological and bioenergetics tolerances are induced by extreme environments in Tupaia belangeri. We integrated the acclimatized and acclimated data in several physiological, hormonal, and biochemical markers of thermogenic capacity and bioenergetics in T. belangeri. Results showed that T. belangeri increased body mass, thermogenesis capacity, protein contents and cytochrome c oxidase (COX) activity of liver and brown adipose tissue in winter-like environments, which indicated that temperature was the primary signal for T. belangeri to regulate several physiological capacities. The associated photoperiod signal also elevated the physiological capacities. The regulations of critical physiological traits play a primary role in meeting the survival challenges of winter-like condition in T. belangeri. Together, to cope with cold, leptin may play a potential role in thermogenesis and body mass regulation, as this hormonal signal is associated with other hormones. The strategies of thermal physiology and bioenergetics differs between typical Palearctic species and the local species. However, the maximum thermal physiology and bioenergetic tolerance maybe is an important strategy to cope with winter-like condition of T. belangeri.Phenotypic plasticity is the ability of individuals to change phenotype with fluctuations in climate conditions, and responses mainly include aspects of morphology, physiology, behavior, and phenology 1 . The energy metabolism of small mammals may be the most suitable field for studying phenotypic plasticity changes 2 . The variation in physiological traits in individuals is an important response to the environment 1,3,4 . Climate conditions, including temperature and photoperiod, play a key role in seasonal variation in body mass, food intake, body fat mass, and other traits 5-9 for many species inhabiting in temperature zone, especially mammals. However, different species show different responses to climate conditions, such as Phodopus sungorus . Small mammals' response to seasonal variations such as cold or short photoperiods, by regulating physiological strategies, such as body mass and thermogenic capacity (e.g., nonshivering thermogenesis, NST) [6][7][8][12][13][14][15][16][17][18][19][20][21][22][23] . The brown adipose tissue (BAT) is a specialized organ that is involved in NST [24][25][26] , and in increased energy expenditure involves the hypothalamic-pituitary-thyroid axis and sympathetic nervous system 27 . The NST capacity entirely depends on uncoupling protein 1(UCP1) in BAT, a 32-kD carrier protein located in the inner membrane of mitochondria, that separates oxidative phosphorylation from adenosine triphosphate synthesis, with energy dissipated as heat 27

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Lin

Yang

Wang

et al. 2017

Sci Rep

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“…We designed species-specific primers for these genes based on the cloned gene sequences of A. chevrieri. Species-specific primers were designed in real-time q-PCR for β-actin and the four hypothalamic genes are shown in Table 1 and verified effectively in A. chevrieri (Zhang et al, 2015). Standard curves were constructed for each gene using serial dilutions of cDNA (1 to 26-fold dilutions).…”

Section: Measurements Of Hypothalamic Neuropeptide Gene Expressionmentioning

confidence: 99%

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

Zhu¹,

Wang²

2016

Comparative Biochemistry and Physiology Part A: Molecular &

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Maintaining adaptive control of behavior and physiology is the main strategy used by animals in responding to changes of food resources. To investigate the effects of random food deprivation (FD) and refeeding on energy metabolism and behavior in Apodemus chevrieri, we acclimated adult males to FD for 4weeks, then refed them ad libitum for 4weeks (FD-Re group). During the period of FD, animals were fed ad libitum for 4 randomly assigned days each week, and deprived of food the other 3days. A control group was fed ad libitum for 8weeks. At 4 and 8weeks we measured body mass, thermogenesis, serum leptin levels, body composition, gastrointestinal tract morphology, behavior and hypothalamic neuropeptide expression. At 4weeks, food intake, gastrointestinal mass, neuropeptide Y (NPY) and agouti-related protein (AgRP) mRNA expressions increased and thermogenesis, leptin levels, pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) expressions decreased in FD compared with controls. FD also showed more resting behavior and less activity than the controls on ad libitum day. There were no differences between FD-Re and controls at 8weeks, indicating significant plasticity. These results suggested that animals can compensate for unpredictable reduction in food availability by increasing food intake and reducing energy expended through thermogenesis and activity. Leptin levels, NPY, AgRP, POMC, and CART mRNA levels may also regulate energy metabolism. Significant plasticity in energy metabolism and behavior was shown by A. chevrieri over a short timescale, allowing them to adapt to food shortages in nutritionally unpredictable environments.

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The role of photoperiod on the expression of hypothalamic genes regulating appetite in Chevrier’s field mouse (Apodemus chevrieri)

Cited by 2 publications

References 52 publications

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri

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