“…This is largely based on evidence that demonstrates exercise promotes Aβ turnover ( Baker et al, 2010 ; Liang et al, 2010 ; Rabin et al, 2018 , 2019 ), the synthesis and release of neurotrophins ( Coelho et al, 2013 , 2014 ), and cerebral ( Burdette et al, 2010 ; Bliss et al, 2020 ) and peripheral blood flow ( Scicchitano et al, 2019 ; O’Brien et al, 2020 ; Pasek et al, 2020 ), while also eliciting a positive systemic inflammatory effect ( Jensen et al, 2019 ; De la Rosa et al, 2020 ). Thus, there is growing support that, at minimum, exercise has the ability to delay the onset of AD and related vascular conditions such as small-vessel-type ischemic stroke and cardiovascular disease ( Ngandu et al, 2015 ; Gallaway et al, 2017 ; Barnes and Corkery, 2018 ; Nystoriak and Bhatnagar, 2018 ; Wardlaw et al, 2019 ; Alty et al, 2020 ; Pasek et al, 2020 ), which African Americans experience at a disproportionately higher prevalence ( Soden et al, 2018 ; Benjamin et al, 2019 ; El Husseini et al, 2020 ). While the benefits of regular exercise are known, many adults are not meeting the recommended amount ( Benjamin et al, 2019 ; Centers for Disease Control and Prevention, 2021 ).…”