The role of physiological studies and apnoea monitoring in infants

Horne, Rosemary Sylvia Claire; Nixon, Gillian M.

doi:10.1016/j.prrv.2014.09.007

Cited by 10 publications

(12 citation statements)

References 84 publications

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“…If a monitor is to be used, it should be accompanied by ongoing medical and technical support, plus psychological support where indicated. 99 Contributors: RSCH conducted the initial literature search and completed the initial draft of the manuscript. FRH and RYM made substantial contributions to manuscript revision.…”

Section: What Is the Advice For Expectant Parents After A Sids Relatementioning

confidence: 99%

Sudden infant death syndrome and advice for safe sleeping

Horne

Hauck

Moon

2015

BMJ

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Section: What Is the Advice For Expectant Parents After A Sids Relatementioning

confidence: 99%

Sudden infant death syndrome and advice for safe sleeping

Horne

Hauck

Moon

2015

BMJ

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“…Compared with other infants, those who subsequently succumb to SIDS have higher heart rates, reduced heart rate variations, abnormal QT intervals, increased baseline heart rates, and bradycardias preceding apnea or during ventilatory effort (129). In this section, we highlight some of the critical events in the nightly SIDS cascade.…”

Section: Introductionmentioning

confidence: 99%

“…Breathing patterns influence cardiovascular response (131, 139) with decreased heart rate variability in the neonate attributable in part to increased sympathetic activity and/or decreased parasympathetic activity with gradually increasing parasympathetic activity over the first year of life (140–142). Infants normally spend about 70% of a 24 h period asleep, and those who subsequently succumb to SIDS demonstrate a decreased heart rate variability due to increased sympathetic activity and/or decreased parasympathetic activity in all sleep phases (active/quiet sleep) (129, 140). Sympathetic activation/catecholamine release in response to hypoxia/hypercapnia is mediated by carotid body glomus cells acutely (143) and by peripheral chemoreceptor organs [e.g., adrenal medulla and oxygen sensing pulmonary neuroendocrine cells (PNEC)] (144).…”

Section: Introductionmentioning

confidence: 99%

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

Elhaik

2016

Front. Neurol.

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Sudden infant death syndrome (SIDS) is the leading cause of death among USA infants under 1 year of age accounting for ~2,700 deaths per year. Although formally SIDS dates back at least 2,000 years and was even mentioned in the Hebrew Bible (Kings 3:19), its etiology remains unexplained prompting the CDC to initiate a sudden unexpected infant death case registry in 2010. Due to their total dependence, the ability of the infant to allostatically regulate stressors and stress responses shaped by genetic and environmental factors is severely constrained. We propose that SIDS is the result of cumulative painful, stressful, or traumatic exposures that begin in utero and tax neonatal regulatory systems incompatible with allostasis. We also identify several putative biochemical mechanisms involved in SIDS. We argue that the important characteristics of SIDS, namely male predominance (60:40), the significantly different SIDS rate among USA Hispanics (80% lower) compared to whites, 50% of cases occurring between 7.6 and 17.6 weeks after birth with only 10% after 24.7 weeks, and seasonal variation with most cases occurring during winter, are all associated with common environmental stressors, such as neonatal circumcision and seasonal illnesses. We predict that neonatal circumcision is associated with hypersensitivity to pain and decreased heart rate variability, which increase the risk for SIDS. We also predict that neonatal male circumcision will account for the SIDS gender bias and that groups that practice high male circumcision rates, such as USA whites, will have higher SIDS rates compared to groups with lower circumcision rates. SIDS rates will also be higher in USA states where Medicaid covers circumcision and lower among people that do not practice neonatal circumcision and/or cannot afford to pay for circumcision. We last predict that winter-born premature infants who are circumcised will be at higher risk of SIDS compared to infants who experienced fewer nociceptive exposures. All these predictions are testable experimentally using animal models or cohort studies in humans. Our hypothesis provides new insights into novel risk factors for SIDS that can reduce its risk by modifying current infant care practices to reduce nociceptive exposures.

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“…Results of epidemiological studies are also difficult to evaluate. This is due to various reasons, particularly differences in the definitions and diagnostic criteria adopted by various authors, or subjective, usually ex post, descriptions of events made by the caregivers or paramedics [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

ALTE — Apparent Life-Threatening Event in children

Bujok

2017

Disaster Emerg Med J

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The data available in the literature associated with apparent life-threatening event (ALTE) in young children, a syndrome rarely diagnosed in Polish emergency departments, are discussed in this paper. The importance of properly conducted interviews, emotional aspects and their practical role in the early management of the case at the site of the event, proposed diagnostic criteria, as well as suggestions for the diagnostic process and decisions related to follow-up are presented.

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The role of physiological studies and apnoea monitoring in infants

Cited by 10 publications

References 84 publications

Sudden infant death syndrome and advice for safe sleeping

Sudden infant death syndrome and advice for safe sleeping

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

ALTE — Apparent Life-Threatening Event in children

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