The Role of PI3K in Met Driven Cancer: A Recap

Hervieu, Alexia; Kermorgant, Stéphanie

doi:10.3389/fmolb.2018.00086

Cited by 32 publications

(34 citation statements)

References 118 publications

(158 reference statements)

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“…The pathways with downregulated expression of DEmRNAs included the JAK‐STAT signaling pathway and MAPK signaling pathway, which were previously found to be associated with malignant tumors . The PI3K‐Akt signaling pathway has been shown to participate in cell proliferation, migration, differentiation, survival, and trafficking in vitro …”

Section: Discussionmentioning

confidence: 95%

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

et al. 2020

Cancer Medicine

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Long noncoding RNAs (lncRNAs) have important biological functions as competing endogenous RNAs (ceRNAs) in tumors, yet the functions and regulatory mechanisms of lncRNA‐related ceRNAs in gastric cancer have not been fully elucidated. In this study, we constructed a lncRNA‐miRNA‐mRNA ceRNA network and identified potential lncRNA biomarkers in gastric cancer. Basing on the RNA profiles downloaded from The Cancer Genome Atlas (TCGA) platform, the gastric cancer‐specific differentially expressed lncRNAs, miRNAs, and mRNAs were screened for constructing a ceRNA network using bioinformatic tools. The enrichment analysis of the biological processes in Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathways was performed on the ceRNA‐related DEmRNAs. According to the modularization of protein‐protein interaction (PPI) network, we extracted a ceRNA subnetwork and analyzed the correlation between the expression of the lncRNAs involved and specific clinical features of patients. Next, the expression of highly up‐regulated in liver cancer (HULC) and RP11‐314B1.2 showed significant changes in several pathological processes involved in gastric cancer, and nine lncRNAs were found to be correlated with the overall survival of patients with gastric cancer. Through the univariate and multivariate Cox regression analyses, two lncRNAs (LINC00106 and RP11‐999E24.3) were identified and utilized to establish a risk score model for assessing the prognosis of patients. The analysis results were also partially verified using quantitative real‐time PCR. The findings from this study indicate that HULC, RP11‐314B1.2, LINC00106, and RP11‐999E24.3 could be considered as potential therapeutic targets or prognostic biomarkers in gastric cancer, and provide a new perspective for cancer pathogenesis research.

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Section: Discussionmentioning

confidence: 95%

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

et al. 2020

Cancer Medicine

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“…Proteins that express a proto-oncogene tyrosine-protein kinase (Src) homology domain 2 (SH2) region bind to the activated receptor, areactivated, and forward the signal to the downstream effectors, propagating critical cellular signaling pathways [ 45 ]. EGFR can simultaneously activate several signal transduction pathways such as phosphatidylinositide 3 kinase (PI3K) and serine–threonine kinase (AKT) and RAS/MAPK pathways [ 46 ].…”

Section: Mechanisms Of Egfr Pathway Activationmentioning

confidence: 99%

Updated Insights on EGFR Signaling Pathways in Glioma

Opriţa

Baloi

Staicu

et al. 2021

IJMS

107

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Nowadays, due to recent advances in molecular biology, the pathogenesis of glioblastoma is better understood. For the newly diagnosed, the current standard of care is represented by resection followed by radiotherapy and temozolomide administration, but because median overall survival remains poor, new diagnosis and treatment strategies are needed. Due to the quick progression, even with aggressive multimodal treatment, glioblastoma remains almost incurable. It is known that epidermal growth factor receptor (EGFR) amplification is a characteristic of the classical subtype of glioma. However, targeted therapies against this type of receptor have not yet shown a clear clinical benefit. Many factors contribute to resistance, such as ineffective blood–brain barrier penetration, heterogeneity, mutations, as well as compensatory signaling pathways. A better understanding of the EGFR signaling network, and its interrelations with other pathways, are essential to clarify the mechanisms of resistance and create better therapeutic agents.

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“…Intriguingly, one of the genes, Gtpbp1, promotes degradation of target mRNA species and plays a role in the regulation of circadian mRNA stability 57 . In some cases, a link with pacemaking can be speculated on: Met is a transcript for a receptor tyrosine kinase, which is known to target phosphoinositide 3-kinase 58 , which in turn is known to target HCN4 31 . Ephb4 is a transcript for another receptor tyrosine kinase, and could it act in a similar way?…”

Section: Metabolismmentioning

confidence: 99%

RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart

Wang

Anderson

Dobrzynski

et al. 2021

Sci Rep

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Physiological systems vary in a day-night manner anticipating increased demand at a particular time. Heart is no exception. Cardiac output is primarily determined by heart rate and unsurprisingly this varies in a day-night manner and is higher during the day in the human (anticipating increased day-time demand). Although this is attributed to a day-night rhythm in post-translational ion channel regulation in the heart’s pacemaker, the sinus node, by the autonomic nervous system, we investigated whether there is a day-night rhythm in transcription. RNAseq revealed that ~ 44% of the sinus node transcriptome (7134 of 16,387 transcripts) has a significant day-night rhythm. The data revealed the oscillating components of an intrinsic circadian clock. Presumably this clock (or perhaps the master circadian clock in the suprachiasmatic nucleus) is responsible for the rhythm observed in the transcriptional machinery, which in turn is responsible for the rhythm observed in the transcriptome. For example, there is a rhythm in transcripts responsible for the two principal pacemaker mechanisms (membrane and Ca2+ clocks), transcripts responsible for receptors and signalling pathways known to control pacemaking, transcripts from genes identified by GWAS as determinants of resting heart rate, and transcripts from genes responsible for familial and acquired sick sinus syndrome.

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The Role of PI3K in Met Driven Cancer: A Recap

Cited by 32 publications

References 118 publications

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

Updated Insights on EGFR Signaling Pathways in Glioma

RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart

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