The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease

Jackson, Leila; Pheneger, Jed; Pheneger, Tracy; Davis, G. Dicky John; Wright, Albion D.; Robinson, John; Allen, Shelley J; Munson, Mark; Carter, Laura

doi:10.1016/j.cellimm.2011.10.011

Cited by 44 publications

(38 citation statements)

References 45 publications

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“…Pan-PIM kinase inhibition in both tumor cells and T cells has been previously shown to reduce cell proliferation and survival (10,47). The specific inhibition of PIM-2 also showed some promising results by delaying tumor burden in a multiple myeloma murine model (18).…”

Section: Discussionmentioning

confidence: 98%

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

Daenthanasanmak¹,

Wu²,

Iamsawat³

et al. 2018

Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 98%

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

Daenthanasanmak¹,

Wu²,

Iamsawat³

et al. 2018

Journal of Clinical Investigation

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“…Inhibition of Pim-1 prevented CD4 ? T cell proliferation without inducing apoptosis [39]. These data suggest that Pim-1 antagonists are effective in treating T cellmediated autoimmune diseases.…”

Section: Discussionmentioning

confidence: 76%

Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice

et al. 2012

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“…CD4 and CD8 refer to the surface markers of various subtypes of T lymphocytes 14,15 . The detection of CD4 þ , CD8 þ T lymphocytes expression and ratio of CD4 þ / CD8 þ may indicate the cellular immune function 16,17 . We next investigated the effects of gossypol on the subsets CD3 þ CD4 þ and CD3 þ CD8 þ T cells by flow cytometric analysis.…”

Section: Discussionmentioning

confidence: 99%

Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways

Song

Huang

Tong

et al. 2013

Immunopharmacology and Immunotoxicology

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Gossypol is a kind of yellow polyphenolic compounds extracted from root stem and seed of the cotton plant. In the present study, we investigated its immunosuppressive mechanism by using BALB/c mouse T lymphocytes in vitro. When mouse splenocytes was incubated with gossypol, the extract effectively suppress the overproduction of the cell stimulated by concanavalin A (ConA) in a dose manner. This inhibitive activity was mainly due to interfering Th1 and Th2 cytokines production and decreasing CD4(+) T cell populations and ratio of CD4(+)/CD8(+). Furthermore, we also showed that signal transduction via NF-κB, NFAT and AP-1 are critical to the ConA-induced T cell activation in mice. The data revealed that gossypol could down-regulate activation of ConA-induced NF-κB, NFAT and AP-1 signal transduction pathways in mouse T lymphocyte. These observations indicated that gossypol exhibited immunosuppressive effects by inhibition T lymphocyte activation in vitro.

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The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease

Cited by 44 publications

References 45 publications

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice

Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways

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