The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells

Xia, Jinghe; Matsuhashi, Sachiko; Hamajima, Hiroshi; Iwane, Shinji; Takahashi, Kazuhiro; Eguchi, Yuichiro; Mizuta, Toshihiko; Fujimoto, Kazuma; Kuroda, Shinya; Ozaki, Iwata

doi:10.1016/j.jnutbio.2011.11.010

Cited by 31 publications

(24 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NFkB activates in response to various inflammatory stimuli, and transcribes the expression of inflammatory cytokines (48). PKCd mediate NFkB activity to initiate inflammatory response in various cell types (49)(50)(51). Cytokines produced by lung epithelial cells may be responsible for enhancing local inflammation by recruiting leukocytes.…”

Section: Discussionmentioning

confidence: 99%

δV1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53

Kim

Zhao

Zhang

et al. 2016

American Journal of Transplantation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

δV1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53

Kim

Zhao

Zhang

et al. 2016

American Journal of Transplantation

View full text Add to dashboard Cite

“…Two other publications from these researchers, again using HCC, explored the effects of vitamin K2 to regulate cancer cell biology [49,50]. In the first they examined potential Vitamin K2 -Vital for Health and Wellbeingmodulation of HCC growth by the anti-cancer therapeutic 5-fluorouracil, through inhibition of cyclin D and innate activated NF-κB signalling.…”

Section: Nf-κb and Vitamin Kmentioning

confidence: 99%

Anti-Inflammatory Actions of Vitamin K

Hodges¹,

Pitsillides²,

Ytrebø³

et al. 2017

Vitamin K2 - Vital for Health and Wellbeing

View full text Add to dashboard Cite

Naphthoquinone compounds have received attention for their ability to regulate diseases from bacterial and parasite infections through to chronic human diseases. Inflammation is widely considered to be at the root of many chronic diseases. The reports of anti-inflammatory activity of naphthoquinones, including vitamin K1 (phylloquinone) and vitamin K2s (menaquinones), are of interest due to their very low toxicity. Most of the evidence for the anti-inflammatory mechanisms of vitamin K suggests a role in the inhibition of the cell signalling complex nuclear factor kappa-B (NF-κB).

show abstract

“…Interestingly, vitamin k2 (VK2) intake seems to be associated with greater benefits of reduced coronary calcification when compared to vitamin k1 consumption [4]. In recent years, various reports have shown that VK2 has antioncogenic effects in various cancer cell lines, including leukemia, lung cancer, ovarian cancer, and hepatocellular cancer [5–9]. Although the exact mechanisms by which VK2 exert its antitumor effect are still unclear, processes such as cell cycle arrest, apoptosis and induction of differentiation appear to contribute to the therapeutic effects of VK2 [5–9].…”

Section: Introductionmentioning

confidence: 99%

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

Samykutty

Shetty

Dakshinamoorthy

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells. Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis. We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells. Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2. Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2. These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells. Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth. Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer.

show abstract

The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells

Cited by 31 publications

References 49 publications

δV1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53

δV1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53

Anti-Inflammatory Actions of Vitamin K

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

Contact Info

Product

Resources

About