This paper investigates how top-down policy direction setting is interpreted and implemented within horizontal networks of practice. This is an under-investigated issue, yet vital for delivering ultimately transformative outcomes. It seeks to unpack how actionable directionality can influence progress and introduces the idea of nascent or partial missions. Options for identifying and nurturing these missions to expand in scale and scope are then discussed. Utilising Wales as an illustrative case study, we draw upon a unique dataset of circular economy (CE)-related interventions, networks and participants. Finally, the paper outlines implications for policy-making and proposes avenues for future research.