The Role of Placental Non-Coding RNAs in Adverse Pregnancy Outcomes

Abstract

Non-coding RNAs (ncRNAs) are transcribed from the genome and do not encode proteins. In recent years, ncRNAs have attracted increasing attention as critical participants in gene regulation and disease pathogenesis. Different categories of ncRNAs, which mainly include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are involved in the progression of pregnancy, while abnormal expression of placental ncRNAs impacts the onset and development of adverse pregnancy outcomes (APOs). Therefore, we reviewed the current status of research on placental ncRNAs and APOs to further understand the regulatory mechanisms of placental ncRNAs, which provides a new perspective for treating and preventing related diseases.

Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy

“…Many lncRNAs associated with tumor cell function may also play significant regulatory roles for trophoblasts because placental trophoblasts share characteristics with tumor cells during proliferation, migration, and invasion (50). This is especially true for pathways involved in angiogenesis, cell cycle regulation, cell migration, and invasion (51). Through interacting with miR-216a-5p and controlling recombinant hexokinase 2(HK2), LncRNA MALAT1 prevents placental trophoblast growth, migration, and invasion, as well as angiogenesis, cell cycle arrest, and apoptosis.…”