“…As part of the methionine cycle, SAM synthesis and metabolism are dependent on the consumption of essential nutrients, such as methionine, folic acid, and cobalamin, whose intakes vary between diets. A growing number of people are transitioning toward plant-based diets worldwide [ 27 , 28 , 29 , 30 , 31 ]. Whether their motivations include mitigation of climate change and food insecurity, animal welfare, health improvement, or other, the study of how nutrition impacts metabolism in such dieters has gained renewed interest, both in adult and paediatric populations [ 32 , 33 , 34 , 35 ].…”