The role of platelet activation in tumor metastasis

Borsig, Lubor

doi:10.1586/14737140.8.8.1247

Cited by 180 publications

(152 citation statements)

References 90 publications

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“…It involves the detachment of tumor cells from the primary tumor, their penetration into blood vessels, as well as their entry into the circulation and adhesion to the endothelium, allowing tumor cell extravasation into the surrounding tissue and colonization at secondary sites [1][2][3][4]. During circulation in the blood stream and resettlement at distant sites, extensive interactions between tumor cells and endothelial cells and/or blood components like platelets occur [5][6][7][8]. These interactions can be mediated by specific ligands, like Sialyl-Lewis X or A that are expressed on the surface of tumor cells and P-and E-selectins found on platelets and endothelial cells, respectively [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…During circulation in the blood stream and resettlement at distant sites, extensive interactions between tumor cells and endothelial cells and/or blood components like platelets occur [5][6][7][8]. These interactions can be mediated by specific ligands, like Sialyl-Lewis X or A that are expressed on the surface of tumor cells and P-and E-selectins found on platelets and endothelial cells, respectively [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Several investigations have demonstrated the significant role platelets play in metastasis by forming aggregates with circulating tumor cells, promoting tumor cell adhesion, and enhancing cancer development and progression [3,[7][8][9]. Tumor cell-induced platelet aggregation results in the development of tumor cell-platelet microemboli [3,5,7,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Tumor cell-induced platelet aggregation results in the development of tumor cell-platelet microemboli [3,5,7,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…These microemboli protect tumor cells from attack by natural killer cells [3,7,13], leading to an enhanced arrest of tumor cell-platelet aggregates in small blood capillaries and facilitating tumor cell invasion into the surrounding tissue [3,5].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation

Wenzel

Zeisig

Haider³

et al. 2009

Breast Cancer Res Treat

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The process of metastasis formation in cancer is not completely understood and is the main reason cancer therapies fail.Previously, we showed that dual liposomes simultaneously containing the haemostatic inhibitor, dipyridamole and the anticancer drug, perifosine potently inhibited metastasis, causing a 90% reduction in the number of lung metastases in a murine experimental metastasis model. To gain deeper insight into the mechanisms leading to the inhibition of metastasis by these dual liposomes, in the present study, the development of metastases by MT3 breast cancer cells in a mouse xenograft model was analyzed in more detail with regard to tumor cell settlement and metastatic growth.We found that the development of lung metastases by MT3 tumor cells is essentially dependent on the formation of fibrin clots as a precondition for the pulmonary arrest of tumor cells and the subsequent intravascular expansion of micro-metastases before their invasion into the surrounding tissue.3

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Tumor cell-induced platelet aggregation results in the development of tumor cell-platelet microemboli [3,5,7,12,13].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation

Wenzel

Zeisig

Haider³

et al. 2009

Breast Cancer Res Treat

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Antitumor Platelet‐Mimicking Magnetic Nanoparticles

Rao

Meng

et al. 2017

Adv Funct Materials

187

144

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Nanoparticles possess the potential to revolutionize cancer diagnosis and therapy. The ideal theranostic nanoplatform should own long system circulation and active cancer targeting. Additionally, it should be nontoxic and invisible to the immune system. Here, the authors fabricate an all‐in‐one nanoplatform possessed with these properties for personalized cancer theranostics. Platelet‐derived vesicles (PLT‐vesicles) along with their membrane proteins are collected from mice blood and then coated onto Fe3O4 magnetic nanoparticles (MNs). The resulting core–shell PLT‐MNs, which inherit the long circulation and cancer targeting capabilities from the PLT membrane shell and the magnetic and optical absorption properties from the MN core, are finally injected back into the donor mice for enhanced tumor magnetic resonance imaging (MRI) and photothermal therapy (PTT). Meanwhile, it is found that the PTT treatment impels PLT‐MNs targeting to the PTT sites (i.e., tumor sites), and exactly, in turn, the enhanced targeting of PLT‐MNs to tumor sites can improve the PTT effects. In addition, since the PLT membrane coating is obtained from the mice and finally injected into the same mice, PLT‐MNs exhibit stellar immune compatibility. The work presented here provides a new angle on the design of biomimetic nanoparticles for personalized diagnosis and therapy of various diseases.

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Biomembrane‐inspired design of medical micro/nanorobots: From cytomembrane stealth cloaks to cellularized Trojan horses

Zhou

Liu

et al. 2023

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Micro/nanorobots are promising for a wide range of biomedical applications (such as targeted tumor, thrombus, and infection therapies in hard‐to‐reach body sites) because of their tiny size and high maneuverability through the actuation of external fields (e.g., magnetic field, light, ultrasound, electric field, and/or heat). However, fully synthetic micro/nanorobots as foreign objects are susceptible to phagocytosis and clearance by diverse phagocytes. To address this issue, researchers have attempted to develop various cytomembrane‐camouflaged micro/nanorobots by two means: (1) direct coating of micro/nanorobots with cytomembranes derived from living cells and (2) the swallowing of micro/nanorobots by living immunocytes via phagocytosis. The camouflaging with cytomembranes or living immunocytes not only protects micro/nanorobots from phagocytosis, but also endows them with new characteristics or functionalities, such as prolonging propulsion in biofluids, targeting diseased areas, or neutralizing bacterial toxins. In this review, we comprehensively summarize the recent advances and developments of cytomembrane‐camouflaged medical micro/nanorobots. We first discuss how cytomembrane coating nanotechnology has been employed to engineer synthetic nanomaterials, and then we review in detail how cytomembrane camouflage tactic can be exploited to functionalize micro/nanorobots. We aim to bridge the gap between cytomembrane‐cloaked micro/nanorobots and nanomaterials and to provide design guidance for developing cytomembrane‐camouflaged micro/nanorobots.

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The role of platelet activation in tumor metastasis

Cited by 180 publications

References 90 publications

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation

Antitumor Platelet‐Mimicking Magnetic Nanoparticles

Biomembrane‐inspired design of medical micro/nanorobots: From cytomembrane stealth cloaks to cellularized Trojan horses

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