The Role of Platelet Derived Growth Factor (PDGF) and Its Receptors in Cancer and Metastasis

Feigelson, Sara W.; Fitzer‐Attas, Cheryl; Eisenbach, Lea

doi:10.1007/0-306-48399-8_8

Cited by 1 publication

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“…La unión de los ligandos PDGF, su consiguiente dimerización y autofosforilación de los residuos de tirosina del dominio quinasa intracelular (2) , crea sitios de acoplamiento para moléculas con dominios SH, involucradas en la transducción de señales (7) . La interacción de estas moléculas con tirosinas fosforiladas específicas en los receptores desencadena la activación de vías de señalización, como PI3K/Akt y MAPK, importantes en supervivencia celular y proliferación, respectivamente (2,5,8) .…”

Section: Introductionunclassified

Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de Plaquetas (PDGF) en un modelo celular de fibrosarcoma humano

Grismaldo¹,

Morales²

2018

Rev. Nutr. Clin. Metab.

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Introduction: Overexposure of the Platelet Derivative Growth Factor (PDGF) and its receptors has been linked to the development of pathologies associated with the loss of proliferation control, like cancer, mainly soft tissue sarcomas and gliomas. Thus, the development of therapeutic elements that inhibit the biological responses unleashed by these molecules have been a topic of preclinical studies in different types of cancer. In that sense, the objective of this study was to evaluate the effect of peptides synthesized from the natural linking of isoform PDGF-BB and specific intracellular protein inhibitors on the activation of modulators of signaling ways PI3K/Akt y MAPK baseline and dependent on PDGF and on the proliferative phenotype of cellular line HT1080. Methods: The baseline for phosphorylation of proteins involved in signaling ways PI3K/Akt y MAPK and cellular line HT1080 derived from human fibrosarcoma was determined and the effect of PDGF-BB stimulation on its proliferation was evaluated, phosphorylation of PDGFRβ (Tyr751), Shp2 (Tyr542), Akt (Ser473) y Erk1/2 (Thr202/Tyr204). At the same time the effect of synthetic peptides designed based on the natural link sequence PDGF-BB was evaluated, as well as the effect on proliferation and the phosphorylation of proteins involved in the signaling ways PI3K/Akt y MAPK unleashed by PDGF-BB. Results: The results suggest that proliferation in line HT1080 is not dependent on the exogenous stimuli with PDGF-BB, although the attempt at signaling indicate a transitory and

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Section: Introductionunclassified

Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de Plaquetas (PDGF) en un modelo celular de fibrosarcoma humano

Grismaldo¹,

Morales²

2018

Rev. Nutr. Clin. Metab.

View full text Add to dashboard Cite

show abstract

The Role of Platelet Derived Growth Factor (PDGF) and Its Receptors in Cancer and Metastasis

Cited by 1 publication

References 137 publications

Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de Plaquetas (PDGF) en un modelo celular de fibrosarcoma humano

Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de Plaquetas (PDGF) en un modelo celular de fibrosarcoma humano

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