THE ROLE OF PLATELET GROWTH FACTOR PDGF AS A PREDICTOR OF FIBROTIC CHANGES IN LUNG PATHOLOGY (literature review)

Abstract

Background. Fibrotic changes as manifestations of a systemic process in the human body are found in a wide range of diseases of the bronchopulmonary system. The genetic component of the process of lung tissue fibrosis, which involves genes of the platelet-derived growth factor (PDGF) family, plays an important role in the clinical course of lung diseases and the formation of isolated consequences, in particular, the development of respiratory failure, which significantly complicates the quality of life of patients. Aim: To determine the role of PDGF family genes in the formation of fibrotic changes in normal and lung pathology, to analyze the ways of correcting the detected disorders. Materials and methods. The article uses the bibliographic method, summarizes scientific publications presented in PubMed and Google Scholar. Results. The literature review presents structural features of PDGF family genes and their receptors (PDGFR). The role of PDGF genes in the processes of physiological development of the lungs, their participation in the mechanisms of the formation of pathological processes accompanied by fibrosis of lung tissue (viral infections, interstitial lung diseases, bronchial asthma) was analyzed. The effectiveness of the use of modern drugs that affect signaling pathways involving genes of the PDGF family and their receptors PDGFR as predictors of the formation of fibrotic changes in lung tissue was evaluated. Conclusion. Genes of the PDGF family play an important role both in the processes of lung development in the neonatal period and in the development of fibrotic changes in lung tissue in a wide range of diseases (viral infections, interstitial lung diseases, bronchial asthma). The introduction into treatment of drugs that affect signaling pathways involving the genes of the PDGF family and the use of tyrosine kinase inhibitors to correct the functioning of PDGFR receptors leads to a reduction in the progression of fibrotic changes in the lung tissue and is one of the modern strategic directions in the treatment of this group of diseases.