The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia

Walle, Muluken; Asrie, Fikir; Gelaw, Yemataw; Getaneh, Zegeye

doi:10.1002/jcla.24305

Cited by 9 publications

(8 citation statements)

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“…In our study, the ROC curve analysis showed that the PLT‐I had the largest AUC among the platelet indices, however, the MPV at a cutoff of 11.3 fL, presented better sensitivity, specificity, PPV, and NPV for the prediction of PE. These findings agree with other studies 14,29 …”

Section: Discussionsupporting

confidence: 94%

“…These findings agree with other studies. 14,29 The parameter PDW, associated with platelet activation was increased in the PE, and GH groups, which was previously described, 30 although no significant increases in PE patients in comparison to normotensive controls were also reported. 22 The PDW can also be associated with the severity of PE.…”

Section: Discussionsupporting

confidence: 65%

“…The median (IQR) ages in years were: 22(20)(21)(22)(23)(24)(25)(26)(27), 25(20.8-29.3), and 24(22)(23)(24)(25)(26)(27)(28)(29)(30) ( p = 0.007) for the groups C, GH, and PE, respectively.The gestational ages in weeks (median (IQR)) were: 31(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), 38(35)(36)(37)(38)(39), and 36.5(34)(35)(36)(37)(38)(39)) ( p = 0.001) for the groups C, GH, and PE, respectively.…”

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confidence: 99%

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Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy

Dionisio,

Favero

2023

Int J Lab Hematology

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IntroductionActivated platelets exert a key role in the pathogenesis of preeclampsia (PE). There is evidence of distinctive patterns of platelet indices in PE in comparison to healthy pregnancies, therefore these indices can be potential tools for PE detection, risk stratification, and management. Considering the vascular aspects of its pathophysiology, PE is characterized by the increased levels of soluble FMS‐like tyrosine kinase‐1 (sFlt‐1) an antiangiogenic factor, and reduced placental growth factor (PlGF), a proangiogenic factor. This study aimed to assess the platelet indices in hypertensive disorders of pregnancy (HDP) and its correlation with angiogenesis‐related biomarkers.MethodsThe groups for the study were: control (n = 114); gestational hypertension; (n = 112), and PE (n = 42). The platelet indices included were platelet counts (PLT‐I and PLT‐F), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P‐LCR), and immature platelet fraction (IPF# and IPF%). Serum levels of sFlt‐1 and PlGF were assessed.ResultsPLT‐I, PLT‐F, and PCT% were lower in PE, while MPV, PDW, P‐LCR, IPF%, and IPF# were increased. The parameter MPV presented the best performance for the discrimination of PE. There was a moderate positive correlation between sFlt‐1 levels and MPV, PDW, and P‐LCR.ConclusionPlatelet indices can be potentially applied as additional tools for the diagnosis and management of HDP. Activated platelets may act as an extra source of sFlt‐1 in PE.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 65%

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confidence: 99%

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Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy

Dionisio,

Favero

2023

Int J Lab Hematology

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“…Platelet count was significantly lower in a preeclamptic group compared to that in a control group, whereas MPV and PDW were significantly higher in women with preeclampsia [ 48 ]. Platelet count had a significant but negative correlation with the duration of hypertension illness, while MPV showed a positive and significant correlation [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Figueroa-Mujica

Ccahuantico

Ccorahua-Ríos

et al. 2022

Life

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The objectives of the study were to determine differences in the parameters of red blood cells (RBC), white blood cells (WBC), and platelets at low altitude (LA) and at high altitude (HA) and with the gestation being advanced, and to determine correlations between parameters of RBC and platelets. We also studied the association of RBC and platelets with markers of iron status. In addition, markers of iron status and inflammation were measured and compared at each trimester of gestation in pregnant women at LA and HA. A cross-sectional comparative study was conducted at Lima (150 m above sea level) and Cusco at 3400 m above sea level from May to December 2019. Hematological parameters in pregnant women (233 at LA and 211 at HA) were analyzed using an automated hematology analyzer. Serum ferritin levels, soluble transferrin receptor (sTfR), hepcidin, erythropoietin, testosterone, estradiol, and interleukin-6 (IL6) levels were measured by ELISA. One-way ANOVA supplemented with post hoc test, chi-square test, and Pearson correlation test statistical analyses were performed. p < 0.05 was considered significant. Pregnant woman at HA compared to LA had significantly lower WBC (p < 0.01), associated with higher parameters of the RBC, except for the mean corpuscular volume (MCV) that was no different (p > 0.05). Platelets and mean platelet volume (MPV) were higher (p < 0.01), and platelet distribution width (PDW) was lower at HA than at LA (p < 0.01). A higher value of serum ferritin (p < 0.01), testosterone (p < 0.05), and hepcidin (p < 0.01) was observed at HA, while the concentration of sTfR was lower at HA than at LA (p < 0.01). At LA, neutrophils increased in the third trimester (p < 0.05). RBC parameters decreased with the progress of the gestation, except RDW-CV, which increased. The platelet count decreased and the MPV and PDW were significantly higher in the third trimester. Serum ferritin, hepcidin, and serum testosterone decreased, while sTfR and serum estradiol increased during gestation. At HA, the WBC and red blood cell distribution width- coefficient of variation (RDW-CV), PCT, and serum IL-6 did not change with gestational trimesters. RBC, hemoglobin (Hb), hematocrit (Hct), mean corpuscular hemoglobin concentration (MCHC), and platelet count were lower as gestation advanced. MCV, MPV, and PDW increased in the third trimester. Serum ferritin, testosterone, and hepcidin were lower in the third trimester. Serum estradiol, erythropoietin, and sTfR increased as gestation progressed. Direct or inverse correlations were observed between RBC and platelet parameters and LA and HA. A better number of significant correlations were observed at HA. Hb, Hct, and RDW-CV showed a significant correlation with serum ferritin at LA and HA. Of these parameters, RDW-CV and PDW showed an inversely significant association with ferritin (p < 0.05). In conclusion, a different pattern was observed in hematological markers as well as in iron status markers between pregnant women at LA and HA. In pregnant women a significant correlation between several RBC parameters with platelet marker parameters was also observed. Data suggest that pregnant women at HA have adequate iron status during pregnancy as reflected by higher serum ferritin levels, lower sTfR levels, and higher hepcidin values than pregnant women at LA.

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“…It is a marker of PLT size, function, and activation as the number and size of pseudopodia increases during PLT activation [ 20 ]. The increased consumption of PLTs obligated the bone marrow to produce and release young and large PLTs [ 15 , 21 ] leading to an increase in MPV in PE patients [ 22 , 23 ]. There were studies conducted on the association of PLT parameters with PE, however, the findings were controversial.…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia has an association with both platelet count and mean platelet volume: A systematic review and meta-analysis

et al. 2022

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Background Preeclampsia (PE) is a pregnancy-specific disorder characterized by endothelial dysfunction, and activation of the coagulation system. Alteration of PLT parameters is the common hematological abnormality observed in women with PE. The main aim of this study was to systematically review previous studies from around the world to generate evidence about the relationship between platelet count (PC) and PE, as well as mean platelet volume (MPV) and PE, by calculating the pooled weighted mean difference (WMD) of PC and MPV between PE and normotensive (NT) groups. Methods Relevant articles which were published in the English language from January 10, 2011, to January 10, 2021, were systematically searched through PubMed, Web of Science, and African journals online. In addition, reference probing of published articles searching was employed through Google Scholar and Google for searching grey literature. The methodological qualities of articles were assessed using Joana Brigg’s institute critical appraisal checklist. A random-effects model was used to estimate pooled WMD of PLT parameters between the two groups with the respective 95% confidence intervals (CI) using Stata version 11.0. The I2 statistics and Egger’s regression test were used to assess heterogeneity and publication bias among included studies, respectively. Results A total of 25 articles were included in this systematic review and meta-analysis. Of which, 23 studies were used in each PC and MPV analysis. The overall pooled WMD of PC and MPV between PE and NT groups were -41.45 × 109/L [95% CI; -51.8, -31.0] and 0.98 fl [95% CI; 0.8, 1.1], respectively. The pooled WMD revealed that PC decreased significantly in the PE group compared to the NT group while MPV increased significantly in the PE group. Conclusions This systematic review and meta-analysis indicated that there is a significant decrease in PC and a significant increase in MPV during PE development among pregnant women. As a result, a change in these parameters among pregnant women may indicate the development of PE.

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The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia

Cited by 9 publications

References 43 publications

Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy

Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy

A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status

Preeclampsia has an association with both platelet count and mean platelet volume: A systematic review and meta-analysis

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