The Role of Platelet Rich Plasma (PRP) and Other Biologics for Rotator Cuff Repair

Greenspoon, Joshua A.; Moulton, Samuel G.; Millett, Peter J.; Petri, Maximilian

doi:10.2174/1874325001610010309

Cited by 15 publications

(13 citation statements)

References 38 publications

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“…PRP and stem cells enhance the regenerative potentials of tendon stem cells [ 12 – 14 ] and regeneration of torn supraspinatus in preclinical studies [ 15 , 16 ]. Several clinical studies have described PRP-augmented rotator cuff repairs in patients with rotator cuff tears [ 17 , 18 ]. Therefore, regenerative biological treatment will be helpful to restore shoulder function and prevent the progression of tear.…”

Section: Introductionmentioning

confidence: 99%

Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

et al. 2018

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BackgroundWe compared the clinical course of rotator cuff tears between rotator cuff exercise and bone marrow aspirate concentration (BMAC)-platelet rich plasma (PRP) injection to identify the therapeutic effects of BMAC-PRP on partial tear of the rotator cuff tendon.MethodsTwenty-four patients with partial tear of the rotator cuff tendon participated in this study. Twelve patients underwent extraction of BMACs and PRP and received the injection of BMAC-PRP at the tear site under ultrasound guidance. Twelve patients in the control group were asked to perform the rotator cuff exercise for 3 months. Visual analog scale (VAS) and manual muscle test (MMT) scores of the supraspinatus muscle were measured, and the American Shoulder and Elbow Surgeons (ASES) score was recorded before, 3 weeks, and 3 months after injection. Tear size was measured by the greatest longitudinal tear length.ResultsThe change in the VAS differed between groups at 3 months (P = 0.039) but not at 3 weeks (P = 0.147). The ASES scores in the BMAC-PRP group changed from 39.4 ± 13.0 to 54.5 ± 11.5 at 3 weeks and 74.1 ± 8.5 at 3 months while those in the control group changed from 45.9 ± 12.4 to 56.3 ± 12.3 at 3 weeks (P = 0.712) and 62.2 ± 12.2 at 3 months (P = 0.011). The tear size decreased at 3 weeks or 3 months after the BMAC-PRP injection but was not significantly different from that in the control group.ConclusionsBMAC-PRP improved pain and shoulder function in patients with partial tear of the rotator cuff tendon.Trial registrationThe patients were registered in the institutional board registry of Samsung Medical Center (registry number 2014-07-173).Electronic supplementary materialThe online version of this article (10.1186/s13018-017-0693-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

et al. 2018

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“…Thus, PRP therapy is suggested as an auxiliary therapy in singlerow arthroscopic rotator cuff repair for ameliorated short period of time outcomes [19]. However, several clinical studies have reported contradictory findings in terms of the appropriateness of PRP for rotator cuff tears [20].…”

Section: Use Of Platelet-rich Plasma In Rotator Cuff Injury Treatmentmentioning

confidence: 99%

Effect of Platelet-rich Plasma and Mesenchymal Stem Cells as Two Biological Alternatives in Rotator Cuff Injury Treatment: A Mini-review

et al. 2019

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The rotator cuff injury introduces as significant damage of trauma and others factors, and currently recognized as a prevalent orthopedic problem. Thus, many clinical procedures have been demonstrated to reduce the complication of rotator cuff injury with varying degrees of success. Platelet-Rich Plasma (PRP) is being enchantingly agreed as one of the most effectiveness strategies for the symptomatic treatment of rotator cuff injury. Many confusing parameters can influence the result of PRP including size of rotator cuff injury, patient age, PRP producing strategy, and number and timing of PRP injections. However, there is some evidences which support beneficial effect PRP in term relieving pain and restoring function, along with minimal adverse effect, in compared with corticosteroids, and other nonsurgical methods. Besides platelet-rich plasma, Mesenchymal Stem Cells (MSCs) are another biological alternative that can be used to treat rotator cuff injuries. Due to lack of large clinical trials applicability, these biological cells have challenges fairly similar to PRP. In conclusion, there is a need for further research to understand the potential application of both of these alternatives as a safe and effective therapeutic option for rotator cuff injuries.

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“…After development of stem cell therapies to assist with RCR and additional clinical results in a human population, a thorough cost-effective analysis is crucial to determine if there is a potential role in RCR. 108…”

Section: Stem Cells: the Early Evidencementioning

confidence: 99%

Evaluating strategies and outcomes following rotator cuff tears

et al. 2018

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Introduction: Rotator cuff tear surgical repair techniques have significantly progressed. However, tendon retear following primary repair persistently occurs at high rates. Rehabilitation protocols, surgical fixation techniques, biologic therapy with scaffolds, platelet-rich plasma, and even stem cell applications are under study to promote adequate tendon healing. Methods: A nonsystematic query of the PubMed database was conducted in July 2016 utilizing the search terms ''rotator cuff repair,'' ''tear,'' ''rehabilitation,'' ''scaffold,'' ''platelet-rich plasma,'' and ''stem cell'' to identify, analyze, and summarize relevant studies. Conclusion: Individualized rehabilitation protocols may be the best approach for small to medium sized tears. Surgical fixation will continue to be debated as modifications to single-row technique and increases in suture number have improved tensile strength. Double-row repairs have been associated with higher costs. Transosseous equivalent technique exhibits comparable subjective and objective outcomes to single-and double-row repair at two-year follow-up. Biocompatible scaffold augmentation has showed inconsistent short-term results. Platelet-rich plasma has lacked uniformity in treatment preparation, administration, and outcome measurement with mixed results. Few human studies have suggested decreased retear rates and improved repair maintenance following bone marrow-derived mesenchymal stem cell augmentation. This review reiterated the necessity of additional high-quality, large-sample studies to develop any final verdict regarding efficacy.

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The Role of Platelet Rich Plasma (PRP) and Other Biologics for Rotator Cuff Repair

Cited by 15 publications

References 38 publications

Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

Effect of Platelet-rich Plasma and Mesenchymal Stem Cells as Two Biological Alternatives in Rotator Cuff Injury Treatment: A Mini-review

Evaluating strategies and outcomes following rotator cuff tears

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