The role of Platelet-Rich Plasma (PRP) intraarticular injections in restoring articular cartilage of osteoarthritic knees. A systematic review and meta-analysis

Prodromidis, Apostolos D.; Charalambous, Charalambos Panayiotou; Moran, Emma; Venkatesh, Ram; Pandit, Hemant

doi:10.1016/j.ocarto.2022.100318

Cited by 8 publications

(11 citation statements)

References 53 publications

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“…There are no studies on PRP and effects on local cartilage repair in the knee. However, studies have been done to look upon the effect of PRP on cartilage volume and thickness in osteoarthritic knees [ 85 ]. Prodromidis et al [ 85 ] looked at 14 studies with PRP injections as OA treatment.…”

Section: Treatment Choicesmentioning

confidence: 99%

“…However, studies have been done to look upon the effect of PRP on cartilage volume and thickness in osteoarthritic knees [ 85 ]. Prodromidis et al [ 85 ] looked at 14 studies with PRP injections as OA treatment. Their study included seven randomized clinical trials (RCTs) ( n = 688), one prospective ( n = 50), one retrospective ( n = 68) and four case series ( n = 224) [ 85 ].…”

Section: Treatment Choicesmentioning

confidence: 99%

“…Prodromidis et al [ 85 ] looked at 14 studies with PRP injections as OA treatment. Their study included seven randomized clinical trials (RCTs) ( n = 688), one prospective ( n = 50), one retrospective ( n = 68) and four case series ( n = 224) [ 85 ]. The PRP preparation process and treatment protocol varied widely (follow‐up 6–12 months).…”

Section: Treatment Choicesmentioning

confidence: 99%

“…The PRP preparation process and treatment protocol varied widely (follow‐up 6–12 months). In this meta‐analysis, PRP treatment was not associated with a significant increase in cartilage thickness (four studies, n = 187) [ 85 ] Meta‐analysis of three RCTs ( n = 112) showed no significant difference in the change of overall knee cartilage content with PRP injections compared with no PRP [ 85 ]. Their conclusion was that the current literature does not support PRP as chondrogeneic treatment alternative of knee OA [ 85 ].…”

Section: Treatment Choicesmentioning

confidence: 99%

“…In this meta‐analysis, PRP treatment was not associated with a significant increase in cartilage thickness (four studies, n = 187) [ 85 ] Meta‐analysis of three RCTs ( n = 112) showed no significant difference in the change of overall knee cartilage content with PRP injections compared with no PRP [ 85 ]. Their conclusion was that the current literature does not support PRP as chondrogeneic treatment alternative of knee OA [ 85 ]. The limits of the conclusion were the substantial heterogeneity in the evaluated studies, which limits the power of any conclusion [ 85 ].…”

Section: Treatment Choicesmentioning

confidence: 99%

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Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine

Brittberg

2024

J. exp. orthop.

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Intact articular cartilage plays a vital role in joint homeostasis. Local cartilage repairs, where defects in the cartilage matrix are filled in and sealed to congruity, are therefore important treatments to restore a joint equilibrium. The base for all cartilage repairs is the cells; either chondrocytes or chondrogeneic cells from bone, synovia and fat tissue. The surgical options include bone marrow stimulation techniques alone or augmented with scaffolds, chondrogeneic cell implantations and osteochondral auto‐ or allografts. The current trend is to choose one‐stage procedures being easier to use from a regulatory point of view. This narrative review provides an overview of the current nonoperative and surgical options available for the repair of various cartilage lesions.Level of EvidenceLevel IV.

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Section: Treatment Choicesmentioning

confidence: 99%