The role of polymorphisms of genes encoding collagen IX and XI in lumbar disc disease

Janeczko, Łukasz; Janeczko, Magdalena; Chrzanowski, Robert; Zieliński, Grzegorz

doi:10.1016/j.pjnns.2013.04.001

Cited by 36 publications

(37 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is estimated that the condition has approximately 75% heredity origin [12]. Genes that have been found to significantly increase risk of LDH include those encoding structural proteins, matrix metalloproteinases, apoptosis factors, growth factors, and single nucleotide polymorphisms in the vitamin D receptor gene resulting in inflammatory cytokine imbalance [11].…”

Section: Genetic Predispositionmentioning

confidence: 99%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

243

202

View full text Add to dashboard Cite

Purpose of Review Substantial advancements have been made in the cause, diagnosis, imaging, and treatment options available for patients with lumbar disc herniation (LDH). We examined the current evidence and highlight the concepts on the frontline of discovery in LDH. Recent Findings There are a myriad of novel etiologies of LDH detailed in recent literature including inflammatory factors and infectious microbes. In the clinical setting, recent data focuses on improvements in computer tomography as a diagnostic tool and non-traditional injection options including tumor necrosis alpha inhibitors and platelet-rich plasma. Operative treatment outcomes have focused on minimally invasive endoscopic approaches and demonstrated robust 5-year post-operative outcomes. Summary Advances in the molecular etiology of LDH will continue to drive novel treatment options. The role of endoscopic treatment for LDH will continue to evolve. Further research into10-year outcomes will be necessary as this surgical approach continues to gain widespread popularity.

show abstract

Section: Genetic Predispositionmentioning

confidence: 99%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

243

202

View full text Add to dashboard Cite

show abstract

“…Moreover, Rathod et al (2012) revealed that COL9A2 gene variation is a cause of this disease in the Indian population. However, Janeczko et al (2014) found no association between COL9A2 polymorphism and risk of intervertebral disc disease. In the present study, we found a significant correlation between COL9A2 sequence variation and risk of this condition in a Chinese population.…”

Section: Discussionmentioning

confidence: 81%

“…To date, several studies have tested the association between the COL9A2 gene and development of intervertebral disc disease in various populations (Annunen et al, 1999;Kales et al, 2004;Virtanen et al, 2007;Rathod et al, 2012;Janeczko et al, 2014). Annunen et al (1999) carried out an investigation involving 157 patients and 174 controls, identifying a COL9A2 genetic mutation that cosegregates with the disease phenotype.…”

Section: Discussionmentioning

confidence: 99%

Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population

et al. 2016

View full text Add to dashboard Cite

ABSTRACT.Intervertebral disc disease is a multifactorial condition, yet disease pathogenesis that can be promoted by a single dominant mutation affecting the expression of susceptibility genes. We performed a case-control study to assess the influence of the COL9A2 Gln326Arg polymorphism on risk of intervertebral disc disease in a Chinese population. Between March 2014 and March 2015, a total of 215 patients and 230 healthy controls were recruited from Binzhou Medical University Hospital. Genotyping of COL9A2 Gln326Arg was carried out using polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate logistic regression analyses revealed that the Arg/Arg genotype of COL9A2 Gln326Arg was associated with increased risk of intervertebral disc disease in comparison to the Gln/Gln genotype [crude odds ratio (OR) = 2.25, 2 T. Meng et al. Genetics and Molecular Research 15 (4): gmr1504895895% confidence interval (CI) = 1.12-4.62; adjusted OR = 2.46, 95%CI = 1.20-5.29]. Moreover, the Arg/Arg genotype correlated with an elevated risk of this disease compared to the Gln/Gln + Gln/ Arg genotypes (crude OR = 2.21, 95%CI = 1.17-4.30; adjusted OR = 2.42, 95%CI = 1.28-5.51). In conclusion, our results suggest that the COL9A2 Gln326Arg polymorphism contributes to the development of intervertebral disc disease in the Chinese population.

show abstract

“…Collagen IX (COL9A2 and COL9A3) 31,32,[37][38][39]42,45,47,48,102,107,116,117) Collagen IX is a structural protein, which consists of the cartilage collagen II/IX/XI heteropolymer. Collagen IX is 31) .…”

Section: Aggrecan Genementioning

confidence: 99%

Genetic background of degenerative disc disease in the lumbar spine

Kawaguchi

2018

Spine Surg Relat Res

View full text Add to dashboard Cite

Abstract:This is a review paper on the topic of genetic background of degenerative disc diseases in the lumbar spine. Lumbar disc diseases (LDDs), such as lumbar disc degeneration and lumbar disc herniation, are the main cause of low back pain. There are a lot of studies that tried to identify the causes of LDDs. The causes have been categorized into environmental factors and genetic factors. Recent studies revealed that LDDs are mainly caused by genetic factors. Numerous studies have been carried out using the genetic approach for LDDs. The history of these studies is divided into three periods: (1) era of epidemiological research using familial background and twins, (2) era of genomic research using DNA polymorphisms to identify susceptible genes for LDDs, and (3) era of functional research to determine how the genes cause LDDs. This review article was undertaken to present the history of genetic approach to LDDs and to discuss the current issues and future perspectives.

show abstract

The role of polymorphisms of genes encoding collagen IX and XI in lumbar disc disease

Cited by 36 publications

References 14 publications

Lumbar Disc Herniation

Lumbar Disc Herniation

Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population

Genetic background of degenerative disc disease in the lumbar spine

Contact Info

Product

Resources

About