The Role of Positron Emission Tomography in Pancreatic Cancer and Gallbladder Cancer

Moradi, Farshad; Iagaru, Andrei

doi:10.1053/j.semnuclmed.2020.04.002

Cited by 16 publications

(8 citation statements)

References 132 publications

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“…GBC prognosis remains poor due to several reasons, with the most important being the vague, non-specific clinical appearance which often leads to delayed diagnosis ( 9 ). Initial ultrasonographic (US) examination is helpful in patients presenting with jaundice, and if US reveals features suggestive of GBC, CT, MRI, and positron emission tomography can be helpful in evaluating the extent of local and distant spread of the disease ( 19 , 20 ). Furthermore, MRCP has been proven to be a reliable method in assessing local and regional spread of GBC ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report

Alaswad,

Otry,

Alhosainy

et al. 2024

Front. Oncol.

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Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, often characterized by nonspecific clinical presentations and late diagnosis, which contribute to its poor prognosis. It is commonly detected at advanced stages, leading to low survival rates. Surgical resection is the primary treatment, with the extent of surgery depending on the T stage of the cancer. In advanced cases, surgery is only considered if it can potentially be curative. Despite various treatment approaches for advanced GBC, survival outcomes remain poor. In our case series, we introduce a novel treatment approach combining cytoreductive surgery, intraoperative radiation therapy, and hyperthermic intraperitoneal chemotherapy. Remarkably, we observed a 100% one-year survival rate, with one patient achieving eight years of disease-free survival without recurrence or metastasis. This aggressive treatment strategy did not lead to increased morbidity or mortality, suggesting its safety and feasibility. However, larger-scale studies are required to draw definitive conclusions.

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Section: Discussionmentioning

confidence: 99%

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report

Alaswad,

Otry,

Alhosainy

et al. 2024

Front. Oncol.

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“…Patients with stents in the common bile duct frequently show uptake in the wall of the gallbladder, likely secondary to inflammation and partial obstruction. Nonetheless, when anatomic imaging is equivocal, FDG PET-CT may be of value in the management of selected patients with gallbladder cancer [ 62 ].…”

Section: Gallbladder Carcinomamentioning

confidence: 99%

PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies

Koppula

Fine

Salem

et al. 2022

Cancers

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PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging and longitudinal surveillance for recurrence. The goal of this series of six review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for specific oncologic indications, and the potential pitfalls and nuances that characterize these applications. In the third of these review articles, key tumor-specific clinical information and representative PET-CT images are provided to outline the role that PET-CT plays in the management of patients with gastrointestinal malignancies. The focus is on the use of 18F fluorodeoxyglucose (FDG), rather than on research radiopharmaceuticals under development. Many different types of gastrointestinal tumors exist, both pediatric and adult. A discussion of the role of FDG PET-CT for all of these is beyond the scope of this review. Rather, this article focuses on the most common adult gastrointestinal malignancies that may be encountered in clinical practice. The information provided here will provide information outlining the appropriate role of PET-CT in the clinical management of patients with gastrointestinal malignancies for healthcare professionals caring for adult cancer patients. It also addresses the nuances and provides interpretive guidance related to PET-CT for imaging providers, including radiologists, nuclear medicine physicians and their trainees.

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“…A more timely and accurate diagnosis of PC would reduce revisits, expedite treatment, and improve the current prognosis of this disease. To date, PC diagnosis relies on imaging modalities, including multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS) [4,[9][10][11][12] and quantitative-elastography endoscopic ultrasound (QE-EUS) [13][14][15] . The first modality of choice for diagnosing PC is MDCT (multidetector CT) [11].…”

Section: Introductionmentioning

confidence: 99%

Bioimpedance Based Biomarker for the Detection of Precancerous and Cancerous Lesions of the Pancreas: Feasibility Animal Study

Dibennardo,

Guidetti,

Fidaner

et al. 2024

Preprint

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Background: Pancreatic cancer (PC) remains a significant healthcare challenge due to its aggressive nature and poor prognosis. The current gold standard that combines imaging modalities, endoscopy, and biopsies has limited diagnostic efficacy due to various shortcomings. Methods: We propose a feasibility study for the use of a bioimpedance biomarker to detect PC. The biomarker was evaluated in a double blind study on ex vivo pancreata of mice: 15 LSL-KrasG12D; LSL-p53R172H; Pdx1-Cre, 2 LSL-KrasG12D, and 9 wild type controls (Study 1). To determine if the biomarker can distinguish between PC and acute pancreatitis (AP), we challenged it with 18 cerulein-induced AP and 6 saline-injected controls (Study 2). Results: The results from Study 1 showed 100% specificity and 94% sensitivity against histopathology outcomes; for Study 2 all AP and saline-injected pancreases were diagnosed as non-cancerous. Regression analysis revealed a positive correlation between biomarker and pathologically analyzed cancer-induced fibrosis (r(24)= 0.73 (p<0.001)). Conclusion: These findings demonstrate the potential of this bioimpedance biomarker as a diagnostic tool for PC.

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The Role of Positron Emission Tomography in Pancreatic Cancer and Gallbladder Cancer

Cited by 16 publications

References 132 publications

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gallbladder cancer: a case report

PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies

Bioimpedance Based Biomarker for the Detection of Precancerous and Cancerous Lesions of the Pancreas: Feasibility Animal Study

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