The Role of Post-Translational Protein Acetylation and Deacetylation in the Apoptosis of Neurons of the Peripheral Nervous System

Dzreyan, V. A.; Demyanenko, S. V.

doi:10.1134/s199074782306003x

Cited by 1 publication

(1 citation statement)

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“…The deacetylation process driven by HDACs executes chromatin compaction and transcriptional repression, while histone acetylation accelerates chromatin accessibility and triggers the activation of gene transcription [76] (Figure 1). The acetylation and deacetylation of proteins may impact the target proteins' stability, activity, localization, and interactions [102]. The reversible protein acetylation may indirectly affect other PTMs through mechanisms like crosstalk between PTMs, protein-protein interactions, recruitment of modifying enzymes, etc.…”

Section: Zinc-dependent Hdacs: Classification Functions Regulations A...mentioning

confidence: 99%

Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology

Patil,

Maloney,

Lucas

et al. 2024

Biomolecules

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A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung EC barrier due to inflammatory or toxic events may result in pulmonary edema, which is a cardinal feature of acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS). The EC functions are controlled, at least in part, via epigenetic mechanisms mediated by histone deacetylases (HDACs). Zinc-dependent HDACs represent the largest group of HDACs and are activated by Zn2+. Members of this HDAC group are involved in epigenetic regulation primarily by modifying the structure of chromatin upon removal of acetyl groups from histones. In addition, they can deacetylate many non-histone histone proteins, including those located in extranuclear compartments. Recently, the therapeutic potential of inhibiting zinc-dependent HDACs for EC barrier preservation has gained momentum. However, the role of specific HDAC subtypes in EC barrier regulation remains largely unknown. This review aims to provide an update on the role of zinc-dependent HDACs in endothelial dysfunction and its related diseases. We will broadly focus on biological contributions, signaling pathways and transcriptional roles of HDACs in endothelial pathobiology associated mainly with lung diseases, and we will discuss the potential of their inhibitors for lung injury prevention.

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Section: Zinc-dependent Hdacs: Classification Functions Regulations A...mentioning

confidence: 99%