The Role of Postoperative Radiation Therapy (PORT) in the Treatment of Extrahepatic Bile Duct Cancer: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Investigation

Abstract

Based on analysis of the SEER database, there was no definitive evidence for improved survival with the addition of PORT to radical surgery. This analysis should be approached with caution given its observational and retrospective nature. In addition, it should be remembered that the SEER database lacks information on the use of chemotherapy, radiation technique, and the completeness of resection.

Total Laryngectomy Versus Larynx Preservation for T4a Larynx Cancer: Patterns of Care and Survival Outcomes

“…The potential influence of immortal time bias and the use of landmark analyses in this clinical setting have been previously well described (17). Consistent with prior studies, we selected a landmark time frame of 3 months, expecting this to adequately account for any potential immortal time bias between surgery and adjuvant RT (18,19). This resulted in 19 additional patients excluded.…”

Radiation therapy for extrahepatic bile duct cancer: Current evidences and future perspectives

“…In the resection subgroup ( n = 31), gross total resection was achieved for only 21 patients, and 10 underwent partial resection. Two studies using the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute[23,24] also concluded there was no definitive evidence for improved survival with the addition of adjuvant RT for resected EBDC. However, the registries in these studies had no information about the extent of resection, and the study period (1973-2004) was too long to reflect the trend of surgery or RT.…”