The role of postoperative radiotherapy in the management of merkel cell carcinoma

Eich, Hans-Theodor; Eich, D.; Staar, S; Mauch, Cornelia; Stützer, H.; Krieg, Thomas; Müller, R.-P.

doi:10.1016/s0959-8049(01)81221-1

Cited by 31 publications

(57 citation statements)

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“…Studies have reported conflicting evidence for the role of adjuvant radiotherapy. [11][12][13][14][15][16][17][18] In a large review of patients treated at the Memorial Sloan Kettering Cancer Center, Allen et al 14 concluded that there was no role for adjuvant radiotherapy in the treatment of MCC. However, other studies have demonstrated a significant association between the addition of adjuvant radiotherapy and improved locoregional control and survival.…”

mentioning

confidence: 99%

Merkel cell carcinoma: An Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients

Howle

Hughes

Gebski

et al. 2012

Journal of the American Academy of Dermatology

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mentioning

confidence: 99%

Merkel cell carcinoma: An Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients

Howle

Hughes

Gebski

et al. 2012

Journal of the American Academy of Dermatology

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“…[21]. In a retrospective analysis by Eich et al [22], five of 14 patients treated with wide excision alone had local recurrences within 2 months. In contrast, only one of 16 patients treated with wide excision followed by radiation therapy developed a recurrence within 15 months after treatment.…”

Section: Treatmentmentioning

confidence: 99%

Merkel cell carcinoma

Lehrer

Hershock²,

Ming

2004

Curr. Treat. Options in Oncol.

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Merkel cell carcinoma is a rare cutaneous neoplasm most commonly affecting the head and neck of elderly white patients. Even with treatment, Merkel cell carcinoma has a strong propensity toward local recurrence, lymphatic spread, and distant metastasis. Because of its rarity and the subsequent lack of well-controlled clinical trials, no single standard of care exists for the treatment of this aggressive tumor. In our institution, primary lesions are excised with wide margins or by Mohs' micrographic surgery. After local removal, the excision site is treated locally with external radiation therapy. Sentinel lymph node mapping and biopsy are performed. Patients with tumor within a sentinel lymph node undergo lymph node dissection and radiation to the lymphatic basin. Adjuvant chemotherapy is offered to high-risk patients with local disease and to patients with metastases. Patients with distant metastases are treated with a combination of salvage chemotherapy and radiation therapy.

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“…Ein chemotherapeutischer Goldstandard in der Therapie des MZK kann derzeit nicht formuliert werden. Die Mehrzahl der adjuvanten Chemotherapieschemata orientiert sich an Protokollen, die beim kleinzelligen Bronchialkarzinom Verwendung finden [9]. Diese sollten beim metastasierten Tumorleiden bereits initial zum Einsatz kommen [41].…”

Section: Lymphknotenmetastasen Und Metastasen Der Lymphabstrombahn (Sunclassified

Peri- und postmenopausale Hormontherapie

Lattrich

Ortmann

2011

Best Practice Onkologie

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Ein hochaggressiver Tumor mit möglicher viraler GeneseDas Merkel-Zell-Karzinom (MZK), auch als "neuroendokrines Karzinom der Haut" bezeichnet, ist ein hochgradig aggressiver dermaler Tumor. Der zelluläre Ursprung des MZK wird kontrovers diskutiert, wohingegen seine ultrastrukturelle und biochemische Verwandtschaft mit den neuroendokrinen Merkel-Zellen der Haut unstrittig ist [37]. Diese gehören dem "amine precursor uptake and decarboxylation system" (APUD-System) an, zu dem auch neuroendokrine Zellen des Gastrointestinal-und Bronchopulmonaltraktes zählen. Der zelluläre Ursprung des MZK besteht möglicherweise aus Merkel-Zellen der basalen Epidermislage oder aber (wahrscheinlicher) aus pluripotenten dermalen Stammzellen mit neuronaler Differenzierung [36].

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The role of postoperative radiotherapy in the management of merkel cell carcinoma

Cited by 31 publications

References 0 publications

Merkel cell carcinoma: An Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients

Merkel cell carcinoma: An Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients

Merkel cell carcinoma

Peri- und postmenopausale Hormontherapie

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