The role of pregabalin in relieving ureteral stent-related symptoms: a randomized controlled clinical trial

Abstract

Pregabalin appears to be a well-tolerated, safe and effective drug in reducing most of USRS, especially relief of pain with subsequent improvement of patient's quality of life. Its combination with solifenacin should be considered to manage patients with USRS as it shows a significant improvement in total USSQ score and general health index when compared to each drug alone.

Relation of postoperative pain medication to return for unplanned care after ureteroscopy

“…There is controversy about the most effective regimen. [4][5][6]10,12,13 Unplanned return visits after ureteroscopy frequently occur due to pain and discomfort. A large portion of symptoms are a result of irritation from an indwelling ureteral stent.…”

“…Many studies have sought to determine the ideal combination to reduce stent discomfort, but most regimens at the authors' institution include narcotic pain medication. 1,[3][4][5][6][7][8][9][10][11] The type of narcotic prescribed depends on surgeon preference; our goal was to determine whether the choice of pain control influenced patients' return rate for unplanned care.…”

Effect of highly concentrated hyaluronic acid/chondroitin sulphate instillation on ureteric stent‐induced discomfort after ureteroscopic lithotripsy: a multicentre randomised controlled pilot study

“…They found that the bladder mucosa normalised after the instillation. Table 4 provides a summary of existing studies about this issue, and most of the studies used the USSQ to measure the clinical discomfort caused by ureteric stenting [31][32][33][34][35][36][37][38][39][40][41]. As shown in Table 3, current existing evidence supports the specific treatment strategy to control discomfort due to ureteric stent indwelling either by a-blockers or other treatments.…”

<p>Strategies to Improve Patient Outcomes and QOL: Current Complications of the Design and Placements of Ureteric Stents</p>

“…A large RCT by Ragab et al highlighted that patients with both pregabalin and solifenacin had better USSQ scores and pregabalin alone was well tolerated and safe in patients with stent-related symptoms. 86 , 87 A small study by Tharwat et al showed that sildenafil was tolerated in men with ureteral-related symptoms. 19 A combination therapy with tamsulosin and oxybutynin has been shown to be effective in improving irritative symptoms, work performance and sexual function.…”