The Role of Presepsin in the Diagnosis of Chronic Obstructive Pulmonary Disease Acute Exacerbation with Pneumonia

Halıcı, Ali; Hür, İzzettin; Abatay, Kerim; Cetin, Esra; Halici, F.; Özkan, Seda

doi:10.2217/bmm-2019-0183

Cited by 12 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Halıcı et al reported that presepsin was useful for diagnosing pneumonia in chronic obstructive pulmonary disease patients with acute exacerbations (AUC 0.70) (64). However, the diagnostic accuracy of presepsin was not higher than of PCT (AUC 0.72) and CRP (AUC 0.75) (64).…”

Section: Presepsinmentioning

confidence: 71%

Diagnostic markers for community-acquired pneumonia

Ito¹,

Ishida²

2020

Ann Transl Med

View full text Add to dashboard Cite

Community-acquired pneumonia (CAP) is one of the respiratory infectious diseases caused by not only bacteria, but also viruses. Antibiotic agents are needed to treat only bacterial but not viral CAP. In addition, there are some non-infectious respiratory diseases in the differential diagnosis of CAP, such as malignant diseases, interstitial lung diseases, pulmonary edema, and pulmonary hemorrhage. We usually diagnose patients having CAP by comprehensive evaluation of symptoms, vital signs, laboratory examinations, and radiographic examinations. However, symptoms and vital signs are not specific for the diagnosis of CAP; therefore, we also use inflammatory biomarkers for differentiating bacterial from viral CAP and non-infectious respiratory diseases. We have used the white blood cell count, C-reactive protein (CRP), and erythrocyte sedimentation rate as common inflammatory biomarkers, but they are not specific for bacterial infection because they could be increased by malignant diseases and collagen diseases. Recently, some inflammatory biomarkers such as procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), pro-adrenomedullin (proADM), and presepsin have been developed as relatively specific biomarkers for bacterial infection. Many reports have evaluated the usefulness of PCT for diagnosing CAP. In this review, the characteristics of each biomarker are discussed based on previous studies.

show abstract

Section: Presepsinmentioning

confidence: 71%

Diagnostic markers for community-acquired pneumonia

Ito¹,

Ishida²

2020

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Higher values of presepsin are associated with septic shock compared to severe sepsis without shock, a trend similar to that observed with PCT [ 1 ]. In probable infections with an identifiable focus, presepsin may be of value in differentiating whether an exacerbation of chronic obstructive pulmonary disease is due to pneumonia or non-infectious in etiology [ 14 ], and may also be useful in patients presenting with nephrolithiasis and systemic inflammatory response syndrome (SIRS) symptoms to rule out pyelonephritis as a cause [ 15 ], and may aid in differentiating between the causes of acute abdomen [ 16 ]. In patients with definite pyelonephritis, a higher presepsin cutoff may be used to test for the presence of bacteremia [ 17 ].…”

Section: Reviewmentioning

confidence: 99%

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

Velissaris¹,

Zareifopoulos²,

Karamouzos³

et al. 2021

Cureus

View full text Add to dashboard Cite

Sepsis is a condition characterized by high morbidity and mortality which is commonly encountered in an emergency and critical care setting. Despite a substantial body of research, the ideal biomarker for the diagnosis and prognostic stratification of septic patients remains unknown. This review aimed to summarize the publications referring to the validity of the biomarker presepsin when used for the detection, monitoring and prognosis in patients suffering with sepsis. This work is a narrative review based on a PubMed/Medline search conducted in order to identify all relevant publications referring to the use of presepsin in sepsis. Search was not limited by year of publication so all articles archived in the database would be retrieved. No article from before 2010 was identified.A total of 57 publications of the last decade were included, all of which support the use of presepsin as a biomarker for the assessment of septic patients. It has been used alone or in combination with commonly used biomarkers in the evaluation of patients with sepsis in settings such as the emergency department and the intensive care unit. It is useful in the initial workup of patients with suspected sepsis in the emergency setting and may be a predictive factor of mortality and the most severe complication of sepsis.Presepsin seems to be a valuable tool for the laboratory workup of sepsis, especially when used in conjunction with other biomarkers and clinical rating scores with an established role in this population. Further research is needed to evaluate the clinical implications of utilizing presepsin measurements in the workup of sepsis.

show abstract

“…sepsin does not have lipopolysaccharide binding properties, so it cannot be captured by anti-CD14 antibodies; thus, this free molecule can be used as a biomarker. Numerous studies have shown that presepsin levels are increased in the early stages of bacteremia and sepsis, and presepsin has been proposed as a biomarker for routine use [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Role of Plasma Presepsin, Procalcitonin and C-reactive Protein Levels in Determining the Severity and Mortality of Community-Acquired Pneumonia in the Emergency Department

2020

Signa Vitae

View full text Add to dashboard Cite

Objective: In this study, we aimed to explore the role of the plasma presepsin level in patients with community-acquired pneumonia during admission to the emergency department in assessing the diagnosis, severity, and prognosis of the disease. In addition, we wanted to investigate the relationship of presepsinin with procalcitonin, C-reactive protein and pneumonia severity scores. Methods: One hundred twenty-three patients over the age of 18 who presented with a diagnosis of pneumonia to the emergency department were included in the study. The vital signs, symptoms, examination findings, background information, laboratory results, and radiological imaging results of the patients were recorded. The 30-day mortality rates of the patients were determined. Results: A statistically significant difference was found between the presepsin levels of the patients diagnosed with pneumonia and those of healthy subjects (p < 0.05). The plasma presepsin levels of the patients who died (8.63 ± 6.46) were significantly higher than those of the patients who lived (5.82 ± 5.97) (p < 0.05). The plasma procalcitonin and C-reactive protein levels of the dead patients were significantly higher than those living (p < 0.05). A presepsin cut-off value of 3.3 ng/mL for 30-day mortality was established (AUROC, 0.65; specificity, 45%; sensitivity, 82%). Procalcitonin is the most successful biomarker in the determination of mortality (AUROC, 0.70). A significant correlation was available between presepsin and lactate, C-reactive protein and procalcitonin (p < 0.05). There was a significant correlation between the Pneumonia Severity Index values and presepsin levels (p < 0.001, r = 0.311). Conclusion: The plasma presepsin level can be utilized for diagnosing community-acquired pneumonia. Plasma presepsin, procalcitonin and C-reactive protein levels can be used to predict the severity and mortality of community-acquired pneumonia.

show abstract

The Role of Presepsin in the Diagnosis of Chronic Obstructive Pulmonary Disease Acute Exacerbation with Pneumonia

Cited by 12 publications

References 25 publications

Diagnostic markers for community-acquired pneumonia

Diagnostic markers for community-acquired pneumonia

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

Role of Plasma Presepsin, Procalcitonin and C-reactive Protein Levels in Determining the Severity and Mortality of Community-Acquired Pneumonia in the Emergency Department

Contact Info

Product

Resources

About